Фенилацетон — Википедия
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Фенилацетон — Википедия
Phenylacetone
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It is a colorless oil that is soluble in organic solvents. This substance is used in the manufacture of methamphetamine and amphetamine , where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry , it was declared a schedule II controlled substance in the United States in From Wikipedia, the free encyclopedia. Benzyl methyl ketone; Methyl benzyl ketone; Phenylpropanone. CAS Number. Interactive image. PubChem CID. Chemical formula. Metabolic pathways of amphetamine in humans \\\\\\\\\\\\\\[sources 1\\\\\\\\\\\\\\]. Benzoic acid. Hippuric acid. Para- Hydroxylation. Beta- Hydroxylation. DBH \\\\\\\\\\\\\\[note 1\\\\\\\\\\\\\\]. Oxidative Deamination. Glycine Conjugation. Department of Justice , Drug Enforcement Administration. Journal of Pharmacology and Experimental Therapeutics. United States Food and Drug Administration. Shire US Inc. December Retrieved 30 December The simplest unsubstituted phenylisopropylamine, 1-phenylaminopropane, or amphetamine, serves as a common structural template for hallucinogens and psychostimulants. Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P and flavin monooxygenase. Amphetamine can also undergo aromatic hydroxylation to p -hydroxyamphetamine. Stereochemical course of the reaction' PDF. Journal of Biological Chemistry. Retrieved 6 November Journal of Pharmaceutical and Biomedical Analysis. British Journal of Pharmacology and Chemotherapy. Hydroxyamphetamine was administered orally to five human subjects The lack of effect of administration of neomycin to one patient indicates that the hydroxylation occurs in body tissues. Unfortunately, at the present time one cannot be completely certain that the hydroxylation of hydroxyamphetamine in vivo is accomplished by the same enzyme which converts dopamine to noradrenaline. Figure 1. Glycine conjugation of benzoic acid. The glycine conjugation pathway consists of two steps. In addition to the factors listed in the boxes, the levels of ATP, CoASH, and glycine may influence the overall rate of the glycine conjugation pathway. Relationship to hypertension and sympathetic activity'. Circulation Research. The percent of the drug hydroxylated to hydroxynorephedrine was comparable in all subjects 6. In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p -hydroxyamphetamine POH and p -hydroxynorephedrine PHN may contribute to the pharmacological profile of the parent drug. Following systemic administration of amphetamine to rats, POH has been found in urine and in plasma. Dexedrine ProCentra Zenzedi. Categories : Amphetamine Ketones Phenyl compounds Benzyl compounds. Namespaces Article Talk. Views Read Edit View history. In other projects Wikimedia Commons. By using this site, you agree to the Terms of Use and Privacy Policy. Other names Benzyl methyl ketone; Methyl benzyl ketone; Phenylpropanone.
Фенилацетон — Википедия
Фенилацетон
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