Fabio Stallone
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Fabio Stallone
Home UniversitĂ€tsspital Basel Klinik fĂŒr Kardiologie Fabio Stallone
UniversitĂ€tsspital Basel · Klinik fĂŒr Kardiologie
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Aims
Cardiac myosinâbinding protein C (cMyC) seems to be even more sensitive in the quantification of cardiomyocyte injury versus highâsensitivity cardiac troponin (hsâcTn), and may therefore have diagnostic and prognostic utility.
Methods and results
In a prospective multicentre diagnostic study, cMyC, hsâcTnT, and Nâterminal proâBâtype natriuret...
Background:
Previous studies have indicated a correlation between heart failure, inflammation and poorer outcome. However, the pathogenesis and role of inflammation in acute heart failure (AHF) is incompletely studied and understood. The aim of our study was to explore the potential role of innate immunity - quantified by complement activation pro...
Background
It is unknown whether higher rates of delayed diagnosis and misdiagnosis of acute coronary syndrome (ACS) in women might have contributed to the poorer outcome of women.
Methods
In a prospective diagnostic multicenter study, we recruited patients presenting to the emergency department (ED) with any kind of chest discomfort/chest pain wit...
Aims:
Treatment goals in acute heart failure (AHF) are poorly defined. We aimed to characterize further the impact of in-hospital haemoconcentration and worsening renal function (WRF) on short- and long-term mortality.
Methods and results:
Haematocrit, haemoglobin, total protein, serum creatinine, and albumin levels were measured serially in 101...
Background:
The early and accurate diagnosis of acute myocardial infarction (AMI) is an important medical and economic challenge. We aimed to prospectively evaluate the performance of the new European Society of Cardiology rapid 0-hour/3-hour (0 h/3 h) rule out protocol for AMI.
Methods:
We enrolled 2,727 consecutive patients presenting with sus...
Background:
Patients presenting very early after chest pain onset may provide a diagnostic challenge even when using a high-sensitivity cardiac troponin (hs-cTnT). We hypothesized that in these patients the incremental value of copeptin in the early diagnosis of acute myocardial infarction (AMI) may be substantial.
Methods:
We aimed to investiga...
Purpose:
Coronary angiography is considered to be a safe tool for the evaluation of coronary artery disease and performed in about 12 million patients each year worldwide. The aim of our study was to investigate the frequency and predictors of cardiomyocyte injury in patients undergoing elective coronary angiography.
Methods:
A total of 749 cons...
Background A pilot study using a novel high-sensitivity cardiac troponin I (hs-cTnI) assay suggested that cTnI might be released into blood during exercise-induced myocardial ischemia. We investigated the potential clinical value of this signal. Methods We included 819 patients with suspected exercise-induced myocardial ischemia referred for rest/b...
A recent pilot study suggested that exercise-induced myocardial ischemia may lead to a delayed release of cardiac biomarkers, so that later sampling e.g. at 4h after exercise could be used for diagnostic purpose.
In an observational study we enrolled 129 consecutive patients referred for evaluation of a suspected coronary artery disease by rest/str...
We aimed to evaluate the efficacy and safety of using high-sensitivity cardiac troponin T (hs-cTnT) within an accelerated diagnostic protocol (ADP) in patients presenting with symptoms suggestive of acute myocardial infarction (AMI) for rapid rule-out of AMI.
In two independent large multicenter studies, levels of hs-cTnT at presentation and at 2h...
The early diagnosis of acute myocardial infarction (AMI) very soon after symptom onset remains a major clinical challenge, even when using high-sensitivity cardiac troponin (hs-cTnT).
We investigated the incremental value of heart-type fatty acid-binding protein (hFABP) in a pre-specified subgroup analysis of patients presenting with suspected AMI...
BACKGROUND: Renal function, as quantified by the estimated glomerular filtration rate (eGFR), is a predictor of death in acute heart failure (AHF). It is unknown whether one of the clinically-available serum creatinine-based formulas to calculate eGFR is superior to the others for predicting mortality. METHODS AND RESULTS: We quantified renal funct...
Objective Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood.
Methods A total of...
Aim:
It is unknown whether cardiac troponin (cTn) I or cTnT is the preferred biomarker in the early diagnosis of acute myocardial infarction without ST segment elevation (NSTEMI).
Methods and results:
In a prospective multicentre study, we measured cTnI and cTnT using clinically available high-sensitivity assays (hs-cTnI Abbott and hs-cTnT Roche...
Importance:
Whether sex-specific chest pain characteristics (CPCs) would allow physicians in the emergency department to differentiate women with acute myocardial infarction (AMI) from women with other causes of acute chest pain more accurately remains unknown. OBJECTIVE To improve the management of suspected AMI in women by exploring sex-specific...
Background: Renal dysfunction seems to decrease the accuracy of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the diagnosis of acute heart failure (AHF). It is unknown, whether one marker is superior over the other in patients with renal dysfunction.
Methods: This prospective study included 632 consec...
Current guidelines require a change (rise and/or fall) in levels of cardiac troponin (cTn) for the diagnosis of acute myocardial infarction (AMI). It is unknown whether absolute or relative changes provide higher accuracy when using high-sensitivity cTnI assays.
In a prospective international multicentre study, we assessed the diagnostic accuracy o...
Klinik fĂŒr Kardiologie Basel, Switzerland
Department of General and Interventional Cardiology
Cardiovascular Research Institute Basel
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