Exposure to exogenous estrogen through intake of commercial milk produced from pregnant cows.2010
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Воздействие экзогенного эстрогена при потреблении товарного молока, полученного от стельных коров, 2010 г.
Сгенерированная сводка:
Поэтому целью настоящего исследования было изучить концентрацию половых гормонов в сыворотке и моче после употребления коровьего молока.
Образцы мочи собирали за 1 час до приема молока и четыре раза каждый час после приема молока.
У мужчин после приема коровьего молока концентрации эстрона и прогестерона в сыворотке крови значительно увеличились, а сывороточные лютеинизирующий гормон, фолликулостимулирующий гормон и тестостерон значительно снизились.
У четырех из пяти женщин овуляция произошла во время приема молока, и время овуляции было одинаковым для трех менструальных циклов.
На половое созревание детей препубертатного возраста может повлиять обычное употребление коровьего молока.
Abstract:
Modern genetically improved dairy cows continue to lactate throughout almost the entire pregnancy. Therefore, recent commercial cow's milk contains large amounts of estrogens and progesterone. With regard to the exposure of prepubertal children to exogenous estrogens, the authors are particularly concerned about commercial milk produced from pregnant cows. The purpose of the present study was therefore to examine concentrations of serum and urine sex hormones after the intake of cow milk.
Subjects were seven men, six prepubertal children, and five women. The men and children drank 600 mL/m(2) of cow milk. Urine samples were collected 1 h before the milk intake and four times every hour after intake. In men the serum samples were obtained before and 15, 30, 45, 60, 90 and 120 min after milk intake. Women drank 500 mL of cow's milk every night for 21 days beginning on the first day of the second menstruation. In three successive menstrual cycles, the day of ovulation was examined using an ovulation checker.
After the intake of cow milk, serum estrone (E1) and progesterone concentrations significantly increased, and serum luteinizing hormone, follicle-stimulating hormone and testosterone significantly decreased in men. Urine concentrations of E1, estradiol, estriol and pregnanediol significantly increased in all adults and children. In four out of five women, ovulation occurred during the milk intake, and the timing of ovulation was similar among the three menstrual cycles.
The present data on men and children indicate that estrogens in milk were absorbed, and gonadotropin secretion was suppressed, followed by a decrease in testosterone secretion. Sexual maturation of prepubertal children could be affected by the ordinary intake of cow milk.