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Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Nichols at Purdue University. It acts as a putatively non-neurotoxic and highly selective serotonin releasing agent SSRA , without the corresponding dopamine and norepinephrine release associated with typical entactogens , which reportedly limits its potential at producing overtly pro-social and euphoric effects. MDAI, or 5,6-methylenedioxyaminoindane, is a synthetic molecule of the aminoindane class with structural similarity to amphetamines. It features the R 3 terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane group, a bicyclic moeity containing a benzene ring fused to a pentane ring. MDAI also contains two oxygen substitutions at R 5 and R 6 joined by a methylene bridge to form a methylenedioxy group. MDAI has been shown to inhibit the reuptake of serotonin and has a selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters , most significantly serotonin. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. MDAI and other similar drugs have been widely used in scientific research as they are able to replicate many of the effects of MDMA , but without causing the neurotoxicity which may be associated with MDMA and some related drugs. No tests have been performed on cardiovascular toxicity. There is currently no scientific data on the lethal dose of MDAI within human beings and the exact toxic dosage is unknown but it is thought to be high in comparison to its active dose. Due to its action as a serotonin reuptake inhibitor , overdoses of this substance would likely result in acute or even fatal serotonin syndrome. It is strongly recommended that one use harm reduction practices when using this substance. The chronic use of MDAI can be considered somewhat addictive with a low potential for abuse and is unlikely to be capable of causing psychological dependence among most users. This is because unlike traditional stimulants, MDAI does not increase concentrations of dopamine. If addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of MDAI develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. MDAI presents cross-tolerance with all serotoninergic stimulants , meaning that after the consumption of MDAI all serotonergic stimulants will have a reduced effect. Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels. As such, it may contain incomplete or wrong information. You can help by expanding it. Navigation menu Personal tools English Create account Log in. Views Read View source View history. Community Network Youtube Good vibes. This legality section is a stub. Как героин действует на организм человека. И продолжаем радовать всех! Мы - это надежное качество клада, это товар высшей пробы, это дружелюбный оператор! Такого как у нас не найдете нигде! Наш оператор всегда на связи, заходите к нам и убедитесь в этом сами! В Телеграмм переходить только по ссылке, в поиске много фейков!

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