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Affiliations

1 Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.

2 Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan t-onoue@med.nagoya-u.ac.jp arima105@med.nagoya-u.ac.jp.

3 Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

4 Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.

5 Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.

Eri Wada et al.

BMJ Open Diabetes Res Care .

2020 Jun .

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Affiliations

1 Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.

2 Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan t-onoue@med.nagoya-u.ac.jp arima105@med.nagoya-u.ac.jp.

3 Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

4 Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.

5 Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.

Schematic illustration of the study design. One-hundred participants were randomly assigned to the flash glucose monitoring (FGM) (n=49) or self-monitoring of blood glucose (SMBG) (n=51) group. Forty-eight participants in the FGM group and 45 participants in the SMBG group completed the study.
Change in glycated hemoglobin (HbA1c). HbA1c was reduced from baseline level in both groups at 12 weeks (flash glucose monitoring (FGM): −0.43% (−4.7 mmol/mol), 95% CI −0.57 to −0.28, p<0.001; self-monitoring of blood glucose (SMBG): −0.30% (−3.3 mmol/mol), 95% CI −0.48 to −0.013 p=0.001); there were no significant between-group differences in this respect in the analysis of covariance (ANCOVA) model (difference −0.13% (−1.4 mmol/mol), 95% CI −0.35 to 0.09; p=0.241). HbA1c was significantly decreased in the FGM group compared with the SMBG group at 24 weeks in the ANCOVA model (FGM: −0.46% (−5.0 mmol/mol), 95% CI −0.59 to −0.32, p<0.001; SMBG: −0.17% (−1.8 mmol/mol), 95% CI −0.05 to 0.11, p=0.124; difference −0.29% (−3.2 mmol/mol), 95% CI −0.54 to −0.05; p=0.022). Change in HbA1c throughout the 24 weeks analyzed using a linear mixed model showed significant improvement in the FGM group compared with the SMBG group (−0.29% (−3.2 mmol/mol), 95% CI −0.53 to −0.06; p=0.014). Data are expressed as mean (95% CI). *Significant difference between groups, p<0.05. †p<0.05 vs baseline.

Dicembrini I, Cosentino C, Monami M, Mannucci E, Pala L.
Dicembrini I, et al.
Acta Diabetol. 2021 Apr;58(4):401-410. doi: 10.1007/s00592-020-01589-3. Epub 2020 Aug 13.
Acta Diabetol. 2021.

PMID: 32789691

Bosi E, Gregori G, Cruciani C, Irace C, Pozzilli P, Buzzetti R.
Bosi E, et al.
Diabetes Res Clin Pract. 2022 Jan;183:109172. doi: 10.1016/j.diabres.2021.109172. Epub 2021 Dec 6.
Diabetes Res Clin Pract. 2022.

PMID: 34883185

Greve SV, Stilgren L.
Greve SV, et al.
Dan Med J. 2020 Jun 1;67(6):A07190404.
Dan Med J. 2020.

PMID: 32741434

Tumminia A, Milluzzo A, Festa C, Fresa R, Pintaudi B, Scavini M, Vitacolonna E, Napoli A, Sciacca L.
Tumminia A, et al.
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1851-1859. doi: 10.1016/j.numecd.2021.03.013. Epub 2021 Mar 24.
Nutr Metab Cardiovasc Dis. 2021.

PMID: 33975741

Clinical Trial.

Yeh HC, Brown TT, Maruthur N, Ranasinghe P, Berger Z, Suh YD, Wilson LM, Haberl EB, Brick J, Bass EB, Golden SH.
Yeh HC, et al.
Ann Intern Med. 2012 Sep 4;157(5):336-47. doi: 10.7326/0003-4819-157-5-201209040-00508.
Ann Intern Med. 2012.

PMID: 22777524

Review.

Glennie JL, Berard L, Levrat-Guillen F.
Glennie JL, et al.
Clinicoecon Outcomes Res. 2022 Feb 10;14:75-90. doi: 10.2147/CEOR.S346736. eCollection 2022.
Clinicoecon Outcomes Res. 2022.

PMID: 35177913
Free PMC article.

Review.

Oser TK, Litchman ML, Allen NA, Kwan BM, Fisher L, Jortberg BT, Polonsky WH, Oser SM.
Oser TK, et al.
Curr Diab Rep. 2021 Dec 9;21(11):49. doi: 10.1007/s11892-021-01408-1.
Curr Diab Rep. 2021.

PMID: 34882273
Free PMC article.

Review.

Al Hayek A, Al Dawish M, El Jammal M.
Al Hayek A, et al.
Cureus. 2021 Jun 28;13(6):e16007. doi: 10.7759/cureus.16007. eCollection 2021 Jun.
Cureus. 2021.

PMID: 34354874
Free PMC article.

Dehghani Zahedani A, Shariat Torbaghan S, Rahili S, Karlin K, Scilley D, Thakkar R, Saberi M, Hashemi N, Perelman D, Aghaeepour N, McLaughlin T, Snyder MP.
Dehghani Zahedani A, et al.
Diabetes Ther. 2021 Jul;12(7):1871-1886. doi: 10.1007/s13300-021-01081-3. Epub 2021 May 28.
Diabetes Ther. 2021.

PMID: 34047962
Free PMC article.

Faber J, Eldrup E, Selmer C, Pichat C, Hecquet SK, Watt T, Kreiner S, Karpatschof B, Gyntelberg F, Ballegaard S, Gjedde A.
Faber J, et al.
Front Neurosci. 2021 Mar 11;15:613858. doi: 10.3389/fnins.2021.613858. eCollection 2021.
Front Neurosci. 2021.

PMID: 33776633
Free PMC article.

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Introduction:

The present study aimed to evaluate the effects of flash glucose monitoring (FGM) and conventional self-monitoring of blood glucose (SMBG) on glycemic control in patients with non-insulin-treated type 2 diabetes.

Research design and methods:

In this 24-week, multicenter, open-label, randomized (1:1), parallel-group study, patients with non-insulin-treated type 2 diabetes at five hospitals in Japan were randomly assigned to the FGM (n=49) or SMBG (n=51) groups and were provided each device for 12 weeks. The primary outcome was change in glycated hemoglobin (HbA1c) level, and was compared using analysis of covariance model that included baseline values and group as covariates.

Results:

Forty-eight participants in the FGM group and 45 in the SMBG group completed the study. The mean HbA1c levels were 7.83% (62.1 mmol/mol) in the FGM group and 7.84% (62.2 mmol/mol) in the SMBG group at baseline, and the values were reduced in both FGM (-0.43% (-4.7 mmol/mol), p<0.001) and SMBG groups (-0.30% (-3.3 mmol/mol), p=0.001) at 12 weeks. On the other hand, HbA1c was significantly decreased from baseline values in the FGM group, but not in the SMBG group at 24 weeks
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