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Harrison G. Pope, Ruth I. Despite the high prevalence of performance-enhancing drug PED use, media attention has focused almost entirely on PED use by elite athletes to illicitly gain a competitive advantage in sports, and not on the health risks of PEDs. There is a widespread misperception that PED use is safe or that adverse effects are manageable. In reality, the vast majority of PED users are not athletes but rather nonathlete weightlifters, and the adverse health effects of PED use are greatly underappreciated. This scientific statement synthesizes available information on the medical consequences of PED use, identifies gaps in knowledge, and aims to focus the attention of the medical community and policymakers on PED use as an important public health problem. PED use has been linked to an increased risk of death and a wide variety of cardiovascular, psychiatric, metabolic, endocrine, neurologic, infectious, hepatic, renal, and musculoskeletal disorders. Because randomized trials cannot ethically duplicate the large doses of PEDs and the many factors associated with PED use, we need observational studies to collect valid outcome data on the health risks associated with PEDs. In addition, we need studies regarding the prevalence of PED use, the mechanisms by which PEDs exert their adverse health effects, and the interactive effects of PEDs with sports injuries and other high-risk behaviors. We also need randomized trials to assess therapeutic interventions for treating the adverse effects of PEDs, such as the anabolic-androgen steroid withdrawal syndrome. Finally, we need to raise public awareness of the serious health consequences of PEDs. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. 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If you believe you should have access to that content, please contact your librarian. For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. To purchase short-term access, please sign in to your personal account above. Don't already have a personal account? Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign in through your institution. Endocrine Society Journals. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Journal Article. Pope, Jr. Oxford Academic. Google Scholar. Ruth I. Alan Rogol. Fred Nyberg. Larry Bowers. Shalender Bhasin. Cite Cite Harrison G. Select Format Select format. Permissions Icon Permissions. Abstract Despite the high prevalence of performance-enhancing drug PED use, media attention has focused almost entirely on PED use by elite athletes to illicitly gain a competitive advantage in sports, and not on the health risks of PEDs. Issue Section:. You do not currently have access to this article. Download all slides. Sign in Get help with access. Endocrine Society members Sign in through society site. Institutional access Sign in through your institution Sign in through your institution. Get help with access Institutional access Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways: IP based access Typically, access is provided across an institutional network to a range of IP addresses. 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Receive exclusive offers and updates from Oxford Academic. More on this topic Cardiovascular Endocrinology: Introduction. Soluble Metalloendopeptidases and Neuroendocrine Signaling. Related articles in PubMed Health outcomes of former division I college athletes. Burnout profiles among esports players: Associations with mental toughness and resilience. Accentuated eccentric resistance training: Effects on physical performance in male and female athletes. Association between cardiorespiratory fitness and trend of age-related rise in arterial stiffness in individuals with and without hypertension or diabetes. Citing articles via Web of Science Papillary Craniopharyngioma: an integrative and comprehensive review. Cardiometabolic Aspects of Congenital Adrenal Hyperplasia. More from Oxford Academic. Clinical Medicine. Endocrinology and Diabetes. Medicine and Health. Authoring Open access Purchasing Institutional account management Rights and permissions. 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