Equipoise In Clinical Trials

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Equipoise and the ethics of clinical research. N Engl J Med. 1987; 317:141-145. doi: 10. 1056/NEJM198707163170304. Crossref Medline Google Scholar; 3. Miller FG, Brody H. Clinical equipoise and the incoherence of research ethics. J Med Philos. 2007; 32:151-165. doi: 10. 1080/03605310701255750. Clinical equipoise is the status of genuine uncertainty by the investigator about the superiority of one treatment arm over the other. The term clinical equipoise was proposed to provide an ethical ground to conduct randomized controlled clinical trials. Equipoise is tradi- tionally defined as a state of genuine uncertainty on the rela- tive value of 2 approaches being compared in a trial. 1 After its inception, equipoise became rapidly embraced as a neces- sary condition for randomization in clinical trials. The main hypothesis put forward here is that there must be a relationship between the overall pattern of treatment successes and the uncertainties that RCTs are designed to address. 3, 6 Since the design of a clinical trial is mostly affected by clinical equipoise, the clinical equipoise hypothesis has been postulated. 3, 6 When the uncertainty . To be in equipoise between two treatments A and B is to be cognitively indifferent between the statement 'A is strictly more effective than B' and its negation. It i … It is widely maintained that a clinical trial is ethical only if some form of equipoise between the treatments being compared obtains. To be in equipoise between two treatments . Clinical equipoise provides the principled basis for medical research involving patients randomly assigned to different treatment arms of a clinical trial, 4 and is considered a necessary feature for clinical service practitioners to ethically enroll patients into clinical trials. 4 This assumption of a state of uncertainty has been identified a. The ethics of clinical research requires equipoise--a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial. Should the investigator discover that one treatment is of superior therapeutic merit, he or she is ethically obliged to offer that treatment. The study was conducted in a fairly large group of 676 patients, out of whom 336 were administered esketamine weekly, while 340 were treated with quetiapine pills. Ketamine outperformed quetiapine . Equipoise is traditionally defined as a state of genuine uncertainty on the relative value of 2 approaches being compared in a trial. 1 After its inception, equipoise became rapidly embraced as a necessary condition for randomization in clinical trials. However, the practical application of this ethical concept has proven far from straightforward. Equipoise in Research: Integrating Ethics and Science in Human Research | Ethics | JAMA | JAMA Network This JAMA Guide to Statistics and Methods article reviews the concept of equipoise, which allows for randomization of interventions while also respecting the ri [Skip to Navigation] Our website uses cookies to enhance your experience. Equipoise, generally defined as uncertainty about the relative effects of the treatments being compared in a trial, is frequently referenced as an ethical standard for the conduct of randomized clinical trials. However, it seems to be defined in several different ways and may be used differently by different individuals. Equipoise The term equipoise is used to express, in precise terms, patient/clinician uncertainty about treatment preference. It is defined as the point where a rational, informed person has no preference between two (or more) available treatments ( Lilford and Jackson, 1995 ). Clinical equipoise, defined as honest professional disagreement among expert clinicians about the preferred treatment, is often cited as the solution to this RCT dilemma. Nevertheless, there. It is defined as a state of disagreement or uncertainty in the informed, expert medical community about the relative clinical merits of the intervention arms in a trial. 1 This state of equipoise may mean that there is insufficient evidence to warrant a judgment that one intervention in the trial is inferior to the others. Definition of Clinical equipoise in the Definitions. net dictionary. Meaning of Clinical equipoise. What does Clinical equipoise mean? . An ethical dilemma arises in a clinical trial when the investigator begin to believe that the treatment or intervention administered in one arm of the trial is significantly outperforming the other arms. A . Clinical Equipoise: A state of genuine uncertainty as to the advantages or disadvantages of each therapeutic arm in a clinical trialDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC. . Equipoise and the ethics of clinical research. N Engl J Med. 1987; 317:141-145. doi: 10. 1056/NEJM198707163170304 Crossref Medline Google Scholar; Previous. Back to top. Next. Figures; References; Related;Davies L, Toye F, Cook J, Price A, Beard D. I struggle with equipoise: a qualitative study exploring clinicians-views of a randomised controlled trial (ACL SNNAP) prior to trial conduct. Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials. Equipoise, the absence of certainty about which intervention is better, is considered a necessary condition for the ethical conduct of randomized controlled trials. 1 The absence of equipoise can challenge the feasibility of conducting a trial and lead to questions regarding the ethics of the trial and validity of the results. The term clinical equipoise was proposed to provide an ethical ground to conduct randomized controlled clinical trials. Objective: The objective of this review is to provide the reader with an overview of the emergence of the term equipoise and its utilization in randomized controlled trials. Methods:Clinical equipoise requires ethical conduct when performing clinical trials that involve assigning patients to different treatment arms. If the outcome of a treatment is known, such a trial has not been encouraged as it could introduce bias. Background. Clinical equipoise is usually construed to mean uncertainty or disagreement amongst the expert clinician community. However, an individual physician's sense of equipoise may vary by location, based on the local standard of care or availability of specific treatment options, and these differences can affect providers' willingness to enroll participants into clinical trials. Equipoise, generally defined as uncertainty about the relative effects of the treatments being compared in a trial, is frequently referenced as an ethical standard for the conduct of randomized clinical trials. However, it seems to be defined in several different ways and may be used differently by different individuals. Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987, although references to its use go back to 1795 by Edward Jenner. Over recent decades, adaptive trial designs have been used more and more often for clinical trials, including randomized controlled trials (RCTs). This rise in the use of adaptive RCTs has been accompanied by debates about whether such trials offer ethical and methodological advantages over traditional, fixed RCTs.

1. https://publiclab.org/notes/print/43381


2. https://source.coderefinery.org/ashwinvis/dotfiles/-/issues/370


3. https://teampages.com/teams/2011267-aasreviewer-weight-lifting-team-website/announcements/2353534--Nebido-Injection-Price


4. https://groups.google.com/g/powerpulsecrew/c/sLLSAEixgp4


5. https://groups.google.com/g/aasguide/c/RoF-6aRci88

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