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1 Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA.
M J Turell et al. J Med Entomol. 1997 May.
Affiliation
1 Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA.
To determine whether anal infusion of virus simulates the natural route of infection rather than intracoelomic injection, we compared the course of Venezuelan equine encephalitis (VEE) virus infection in Amblyomma cajennense (F.) ticks that had been exposed to virus by enema infusion with that in ticks fed on a viremic host or exposed by intracoelomic inoculation. Although virus was detected in virtually all ticks 14 d after exposure, orally exposed ticks contained significantly less virus (10(1.9) plaque-forming units [PFU] per tick) than did ticks infected by enema (10(4.1) PFU per tick) or intracoelomically (10(4.2) PFU per tick). At 42 d after virus exposure, only 1% of 512 orally exposed ticks contained virus, but most enema (77%, n = 43) or intracoelomically (79%, n = 29) exposed ticks were infected. Replication of VEE virus in A. cajennense ticks exposed to virus by enema infusion, therefore, appeared more similar to that of ticks inoculated intracoelomically than to those exposed orally. Thus, because enema infusion may bypass potential midgut infection and escape barriers, this procedure may not be appropriate for determining vector competence in ixodid ticks.
Linthicum KJ, Gordon SW, Monath TP. Linthicum KJ, et al. J Med Entomol. 1992 Sep;29(5):827-31. doi: 10.1093/jmedent/29.5.827. J Med Entomol. 1992. PMID: 1404262
Dohm DJ, Linthicum KJ. Dohm DJ, et al. J Med Entomol. 1993 Jan;30(1):286-90. doi: 10.1093/jmedent/30.1.286. J Med Entomol. 1993. PMID: 8433340
Linthicum KJ, Logan TM, Bailey CL, Gordon SW, Peters CJ, Monath TP, Osorio J, Francy DB, McLean RG, Leduc JW, et al. Linthicum KJ, et al. J Med Entomol. 1991 May;28(3):405-9. doi: 10.1093/jmedent/28.3.405. J Med Entomol. 1991. PMID: 1875367
Linthicum KJ, Logan TM. Linthicum KJ, et al. J Med Entomol. 1994 Mar;31(2):306-9. doi: 10.1093/jmedent/31.2.306. J Med Entomol. 1994. PMID: 8189423
Belova OA, Burenkova LA, Karganova GG. Belova OA, et al. Ticks Tick Borne Dis. 2012 Sep;3(4):240-6. doi: 10.1016/j.ttbdis.2012.05.005. Epub 2012 Aug 19. Ticks Tick Borne Dis. 2012. PMID: 22910062
Gargili A, Estrada-Peña A, Spengler JR, Lukashev A, Nuttall PA, Bente DA. Gargili A, et al. Antiviral Res. 2017 Aug;144:93-119. doi: 10.1016/j.antiviral.2017.05.010. Epub 2017 Jun 1. Antiviral Res. 2017. PMID: 28579441 Free PMC article. Review.
Nuckols JT, Ziegler SA, Huang YJ, McAuley AJ, Vanlandingham DL, Klowden MJ, Spratt H, Davey RA, Higgs S. Nuckols JT, et al. Vector Borne Zoonotic Dis. 2013 Feb;13(2):103-10. doi: 10.1089/vbz.2012.1013. Epub 2012 Dec 18. Vector Borne Zoonotic Dis. 2013. PMID: 23249139 Free PMC article.
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How to Use an Enema for Clearing the Bowel
Verywell Health's content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved
Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16.
Medically reviewed by Robert Burakoff, MD, MPH on September 08, 2020
Robert Burakoff, MD, MPH, is board-certified in gastroentrology. He is the vice chair for ambulatory services for the department of medicine at Weill Cornell Medical College in New York.
An enema is the introduction of liquid, most often mineral oil, through the anus and into the large intestine. An enema may be given to treat constipation,1 to administer medication or barium, or as part of the procedure to empty the contents of the bowel before a test (such as​ a colonoscopy prep).
Enemas may also sometimes be given before surgery on the abdomen or during labor at the end of pregnancy, but this is no longer common.
Using homemade enemas are not recommended, nor is using an enema containing liquids or substances other than what is recommended by a physician. There is no evidence that using an enema for "detoxing" or for reasons other than cleaning the bowel before a test or procedure or for removing impacted stool has any health benefits.
There could be harm in using enemas too often, or in using enemas with substances that may disrupt the balance of the beneficial bacteria found in the large intestine.
An enema is both a verb and a noun: it refers to the actual device and the act of using it.
An enema that one buys in the pharmacy has a nozzle on the end of a small bag. The bag is filled with the liquid that's to be injected into the body. The nozzle is inserted into the anus and the bag is squeezed, sending the liquid out of the nozzle and into the last part of the colon (the rectum). 
The liquid is usually held in the rectum for some specified amount of time. It could just be held until the urge to move the bowels comes on. In some cases, it might be suggested that the enema is held inside the body for a few minutes or longer.
When it's time, the enema and the waste material that is in the rectum is released by sitting on the toilet and moving the bowels like normal.
In some cases, the liquid used in an enema is just salt water, and in other, it contains a laxative.1 Check with your doctor if you are unsure as to which type of enema is recommended for you. Here are some common types of enema liquids:
In the treatment of some types of conditions, including inflammatory bowel disease (IBD), medication might be given with an enema. Rowasa (a 5-aminosalicylic drug), used to treat ulcerative colitis, is given this way.
This is usually to treat inflammation that is found in the last section of the colon, where the enema liquid will reach, but that might not be the case in all uses. It's usually recommended that these enemas are used at night, and that instead of releasing the bowels, that the enema is held in all night, to give the medication time to work.3
There are practitioners who offer enemas with other substances in them (coffee, lemon juice, milk), which are claimed to offer some health benefits. Use of these types of enemas without the supervision of a physician is not approved or recommended to treat any condition.
People with IBD should be especially wary of these types of enemas. There is the potential to introduce harmful materials into the body with the use of a nonmedical enema. In addition, the colon contains various forms of beneficial bacteria, and the use of an enema may disrupt the bacterial flora and cause harm.
Enemas are not harmless and should be used only on the advice of a physician. Using enemas on a regular basis can have an effect on the muscles in the colon. In time, the muscles will stop working properly to move stool along, which worsens the problems with constipation.
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Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Portalatin M, Winstead N. Medical management of constipation. Clin Colon Rectal Surg. 2012;25(1):12–19. doi:10.1055/s-0032-1301754
Cleveland Clinic. Mineral Oil rectal enema. Updated January 19, 2017.
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Verywell Health's content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved
Verywell Health is part of the Dotdash publishing family.

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