EPITHALON

Epithalon/Epitalon is a synthetic tetrapeptide isolate composed of the four amino acids alanine, glutamic acid, aspartic acid, and glycine. It is derived from epithalamin, a crude polypeptide extracted from the pineal gland.

The synthetic peptide was developed in the 1980s by a research team led by Professor Vladimir Khavinson of the St. Petersburg Institute of Bioregulation and Gerontology and has since been the subject of extensive research in cell cultures, animals, and humans.

What Does Epithalon Do?

Epithalon upregulates telomerase activity and elongates telomeres, which has prompted research in areas including life extension, anti-aging, and the inhibition of tumorigenesis

Known to regulate gene expression and protein synthesis, Epithalon has been found to suppress both the CCl11 and HMGB1 genes, thereby increasing the lifespan of test subjects.

It also has significant antioxidant effects and has been shown to inhibit carcinogenic receptor expression, which has led to research into its potential anti-tumour effects in breast and colorectal cancer.

Epithalon has been investigated as a potential treatment for rheumatoid arthritis and ulcerative colitis due to its ability to regulate biomolecules involved in the inflammation process, such as cytokines and C-reactive protein

The peptide has also been investigated as a regulator of the sleep cycle, as it increases levels of melatonin and endogenous gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive function but naturally decline with age.

Epithalon Benefits 

Epithalon and DNA repair

Research indicates that epithalon may be used to protect against and repair DNA damage, given its potent antioxidant activity. For example, it has been shown to:

• Decrease levels of DNA damage when administered to senescence-accelerated mice
• Stimulate cortical neurons when administered intranasally to rodents
• Increase levels of the DNA-binding protein phosphor-CREB
• Improve antioxidant defence systems in flies and rats

Epithalon and longevity

It is known that epithalon regulates gene expression and protein synthesis, with the general effect of reducing mortality and delaying the progression of age-associated diseases in the elderly

In an in vitro study conducted by Professor Khavinson and colleagues in 2003, the team demonstrated that epithalon elongates telomeres and induces telomerase activity when introduced to telomerase-negative human foetal fibroblast cultures. The researchers concluded that epithalon may prolong the lifespan of cell populations through anti-senescence activity.

Epithalon and sleep

Animal studies have shown that the peptide increases melatonin may therefore enhance sleep and promote brain health.

The link between melatonin and brain health has been clarified in more recent research by Chitimus et al., noting that melatonin has antioxidant properties and can help protect the brain from oxidative stress.

Since oxidative stress may contribute to neurodegenerative disorders, there is strong research interest in epithalon’s role in optimizing sleep and maintaining overall brain health

Epithalon Dosage Calculator

Insofar as epithalon is sold as a reference material, there are no universally agreed-upon guidelines for dosing the peptide in test subjects.

• Total Dosage: 100mg epithalon
• Frequency: Administer 10mg of epithalon daily, in one to two subcutaneous injections. For twice-daily injections, administer once in the morning and once at night.
• Study Period: 10 days
• Notes: Administer this protocol up to 2 times per year. Each course should be followed by a pause of at least four months.