Dissertation Gvhd

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"Pathogenesis of Dry Eye in Graft Versus Host Disease . . .
Theses & Dissertations - Jefferson Digital Commons
Distinct T Cell Clones Are Associated With Graft-versus . . .
"Defining and Manipulating the Function of Protein Kinase . . .
"Distinct T Cell Clones Are Associated With Graft-versus . . .
Tim-3/Gal-9 and B7-H3 act as negative regulators of graft . . .
Impact of Conditioning Regimen Choice: The Role of . . .
"Targeting T-bet for Prevention of Graft-Versus-Host . . .
Theses and Dissertations--Microbiology, Immunology, and . . .
Mast Cells As Novel Effector Cells in The Pathogenesis of . . .
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Allogenic hematopoietic stem cell transplantation is a procedure that offers a possible cure for hematologic cancers and other hematologic disorders . Unfortunately, despite the increasing survival rate of patients, the quality of their life is adversely affected by the allogeneic bone marrow transplantation's major side effect i .e Graft vs . Host Disease ( GVHD ) .
Graft-versus-host-disease ( GVHD ) is a major complication of major histocompatibility complex (MHC) matched bone marrow transplantation . GVHD is the result of an immune-mediated attack, by T lymphocytes derived from donor bone marrow, against recipient tissues expressing minor histocompatibility antigen (miHA) differences . There is a lack of knowledge concerning the nature of in vivo immune . . .
DISTINCT T CELL CLONES ARE ASSOCIATED WITH GRAFT-VERSUS-HOST DISEASE ( GVHD ), AND POTENTIALLY GRAFT-VERSUS-TUMOR (GVT), RESPONSES FOLLOWING ALLOGENEIC STEM CELL TRANSPLANTATION By Jennifer Berrie A Dissertation submitted in partial fulfillment of the requirements for the degree of Master's of Science at Virginia Commonwealth University .
Immune-mediated tissue destruction of graft-vs-host disease ( GvHD ) remains a major barrier to greater use of bone marrow transplantation (BMT) . It is found that alloreactive donor-derived T cells activated through their T cell receptor (TCR) are primarily the major contributors to the immunopathobiology of GvHD . Protein kinase C-theta (PKCtheta), a crucial, early downstream kinase of TCR . . .
We identified Vbeta families of increased expression involved in GVHD or GVT responses, with Vbetas 4, 11, and 23 being associated with GVHD , Vbetas 9, 16, and 20 being associated with GVT, and Vbetas 2, 3, 7, 8, 12, 15, and 17 being involved in GVHD and/or GVT .
GVHD occurs when there is an antigen disparity between the donor and the recipient . This disparity leads to activation of donor T cells that migrate to GVHD target organs and mediate damage . Current therapies involve broad immune suppression that can lead to toxicity and increased relapse rates for cancers .
This dissertation will describe work investigating the use of the pre-transplant conditioning regimen as a means of mitigating alloreactive T-cell responses and limiting GvHD . This proof-of-concept will first be demonstrated in a study evaluating the effect of alternative conditioning regimens on host dendritic cells in a murine bone marrow . . .
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapeutic option for many malignant diseases . However, the efficacy of allo-HSCT is limited by the occurrence of destructive graft-versus-host disease ( GVHD ) . Since allogeneic T cells are the driving force in the development of GVHD , their activation, proliferation, and differentiation are key factors to . . .
Hematopoietic stem cell transplantation (HSCT) is most commonly a treatment for inborn defects of hematopoiesis or acute leukemias . Widespread use of HSCT, a potentially curative therapy, is hampered by onset of graft-versus-host-disease ( GVHD ), a condition wherein the donor cells recognize the patient tissues as non-self . GVHD can manifest anywhere from weeks to decades post-transplant and is . . .
Theses and Dissertations --Microbiology, Immunology, and Molecular Genetics Microbiology, Immunology, and Molecular Genetics 2020 MAST CELLS AS NOVEL EFFECTOR CELLS IN THE PATHOGENESIS OF CHRONIC GRAFT-VERSUS-HOST DISEASE Ethan Strattan University of Kentucky, ethan .strattan@uky .edu Author ORCID Identifier:
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Dissertation Gvhd