Dating Of Secretory Endometrium
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Endometrium: Secretory phase | Pathology Made Simple
Histological dating of secretory endometrium: What . . .
Secretory endometrium | MyPathologyReport .ca
Error in histologic dating of secretory endometrium . . .
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ilovepathology .com › endometrium-secretory-phase
The endometrium is obtained for evaluation by a process called dilatation and curettage or by endometrial biopsy . This is done to evaluate infertility or dysmenorrhea . Dating of endometrium : Proliferative phase . Glands . stroma . Early proliferative (day 4-7 ) Straight short glands, thin epithelium . Compact .
The story of the histological dating of secretory endometrium provides an excellent demonstration of a test whose practice became dogma before it was appropriately tested . It started as a test to demonstrate ovulation, it "morphed" into a test to demonstrate adequate P production and appropriate responsiveness of the endometrium and, finally, was linked to clinical conditions such as luteal phase deficiency and recurrent pregnancy loss .
Endometrial dating . Follow up of previously diagnosed endometrial hyperplasia . Endometrial or endocervical polyps . Infertility . The diagnosis of secretory endometrium means that your pathologist saw specific features including an increased amount of tissue, twisted glands, and secretions when your tissue sample was examined under the microscope .
Error in histologic dating of secretory endometrium : variance component analysis . Gibson M(1), Badger GJ, Byrn F, Lee KR, Korson R, Trainer TD . Author information: (1)University of Vermont College of Medicine, Burlington . OBJECTIVE: To characterize the extent and sources of imprecision in histologic dating of the endometrial biopsy .
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The pathologist can improve this to 2-3 days, however, by acquiring expertise in endometrial dating (all cases of normal endometria are to be dated regardless of reasons for sampling), and by basing the dating on those endometrial morphologic alterations that represent the most advanced phase of the menstrual cycle .
Endocervical epithelium (ECE) has a morphology similar to the epithelium of secretory phase endometrium (SPE): ECE - grey foamy appearing cytoplasm . SPE - eosinophilic cytoplasm . Most useful feature to differentiate ECE and SPE is the accompanying stroma . DDx: Endometrial hyperplasia with secretory changes . Endometrium with hormonal changes .
Dating the endometrium is identifying morphologic changes characteristic for early, middle, and late proliferative endometrium and for each of the 14 days of secretory endometrium (1, 2) .
Early secretory phase (Day 17 - 19) Day 17: Continuous and well developed subnuclear vacuoles in > 50% of a gland, rare mitoses Day 18: Sub- and supranuclear vacuoles (piano keys) with nuclei in the center of cell Day 19: Nuclei at base of cell, supranuclear vacuoles, start of luminal secretions . Mid secretory phase (Day 20 - 22)
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In this review, dating of the endometrium will not be discussed, as this has been dealt with in detail recently . 1 Similarly, pure mesenchymal lesions, benign or malignant, may be identified on endometrial biopsy and these will not be discussed further .
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Dating Of Secretory Endometrium
