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Cannabis is a genus of plant that contains three varieties: Cannabis indica , Cannabis sativa , and Cannabis ruderalis. It is a flowering herb with a long, rich history of medicinal, recreational, nutritional, and industrial use throughout the world. With some countries, including Canada, having legalized cannabis, there has been a recent surge of worldwide attention on the plant. There is increasing interest in seeing the plant legalized for medicinal and recreational purposes in other countries and increasing excitement about the possibility of research on the medicinal uses and safety of cannabis, which legalization would make more accessible. The cannabis plant originated in central Asia, where people first discovered it at least 12, years ago, during the early days of agriculture. Initially, they would use cannabis by eating the nutritious seeds and creating rope and textiles from the hemp stalks. However, the first written record of medical cannabis use in China was nearly 5, years ago. Over the years, cannabis use spread across the continent and then the world, and many peoples continued to use it to treat a variety of ailments. Ancient Egyptians used cannabis to treat hemorrhoids and ease childbirth. Evidence from India shows documents dating back thousands of years praising its ability to decrease anxiety and increase happiness. There is evidence in many parts of the world of medicinal use of cannabis, but even more evidence of industrial use, with importance placed on hemp textiles. Throughout the 19 th century, it was a popular remedy in the United States. Consumers could purchase cannabis tinctures and other preparations from pharmacies, and use these products to treat a range of ailments. These included gastrointestinal diseases, mental illnesses, nausea, headaches, insomnia, asthma, epilepsy, menstrual cramps, and many other symptoms, diseases, and disorders. However, by the 20 th century, cannabis began to fall out of favour in North America. In , Canada was one of the first countries to add cannabis to its list of prohibited drugs, leading to a year prohibition on cannabis, ending upon legalization in October Throughout the mid th century, researchers found and isolated a variety of cannabinoids, allowing them to understand more about the function of cannabis. Subsequent research on this receptor led to the discovery of anandamide, a neurotransmitter that activated some of the same receptors as cannabis. In , researchers discovered another receptor in the endocannabinoid system, as well as more of these unique neurotransmitters. In , Canada introduced the Medical Marijuana Access Regulations, allowing individuals with certain diseases to access government-issued cannabis if their physician recommended it and they met established criteria. In and , two separate bills were introduced by the federal government with the goal of decriminalizing small amounts of cannabis, but neither of these succeeded. While public opinion of cannabis has gone through many shifts, in recent years, public interest in Canada has continued to grow. Now, with legalization of cannabis in Canada as of , we hope to see more research, dialogue, and deeper understanding of how cannabis works in humans. Cannabis is composed of many different substances, and more than of these are what we call cannabinoids. These, possibly along with other compounds known as terpenes, are responsible for the effects of cannabis. Cannabinoids most likely work by interacting with a complex system in the body called the endocannabinoid system ECS. Our bodies naturally produce a family of neurotransmitters called endocannabinoids, which interact with receptors located in the brain, muscles, fat, and digestive tract. These receptors are called cannabinoid receptor type 1 CB 1 and cannabinoid receptor type 2 CB 2. Scientists only recently found evidence of the ECS when they discovered CB 1 in , so research is still ongoing into exactly how it functions. However, most data find that it helps our bodies regulate pain, mood, appetite, gastrointestinal motility, memory, emotions, stress response, immune function, and more. When a person ingests the plant-based cannabinoids in cannabis, which are similar molecular shapes to endocannabinoids, they fit into the CB 1 and CB 2 receptors and trigger reactions that result in either very high or very low levels of specific neurotransmitters, which the cells of the nervous system, as well as other systems in the body, use to communicate with each other. The ECS is very important when it comes to medicinal cannabis, because changes in how the ECS functions might have an important relationship to the pathology of chronic conditions and could be tied to the efficacy of cannabinoids. The two most important cannabinoids, and the two that typically compose the majority of cannabinoids in cannabis, are deltatetrahydrocannabinol THC and cannabidiol CBD. THC is also the primary source of the negative psychological effects associated with cannabis use, such as irritability, anxiousness, and paranoia. CBD can help reduce convulsions, nausea, and inflammation. It might also lessen some of the negative symptoms associated with THC, especially anxiety and paranoia. When we develop cannabis to grow tall and strong with thick fibrous stalks that are low in THC we typically refer to it as hemp. People mostly use hemp seeds for food and its fibres for industrial purposes, such as for creating textiles and building materials, or for extracting CBD for medicine. When we breed it to have lush leaves and flowers that are high in cannabinoids, we use the flower buds for medicinal or recreational purposes. Some people refer to cannabis used this way as marijuana. Typically, Cannabis ruderalis is very low in cannabinoids, and only used for hemp. Plant breeders have created innumerable strains of cannabis, each of which has a different combination of cannabinoids, with variable potency results. The list of conditions that cannabis is purported to treat or cure is very long, and continues to grow, but the research is still lacking in many areas. This is largely due to cannabis being both stigmatized and illegal in most parts of the world for the past century, so research might increase as legalization becomes more commonplace. It is also difficult for researchers to conduct double-blind studies for most cannabis products because subjects might be able to determine whether they are on the active therapy or placebo. However, current research indicates that some conditions may be clinically improved by cannabis use. These include inflammatory bowel disease , multiple sclerosis, neuropathic pain , nausea and vomiting caused by cancer or chemotherapy, pediatric seizure disorders, and a wide variety of other illnesses. Here, we will focus on gastrointestinal symptoms and conditions that might be ameliorated by cannabis. Some research suggests that the ECS might play a role in gut health. In addition, research shows that levels of anandamide, an endocannabinoid, are much lower in the inflamed gut mucosa of those with IBD than in healthy gut tissue. Early research on the effects of cannabis on IBD is quite promising, but we still have far to go before we can definitively say that cannabis is an effective treatment for IBD. For example, before using cannabis, each individual took some sort of prescription medication to treat their disease. When using cannabis, nine individuals were able to cease all prescription medication use. They also reported a drop in daily bowel movements from eight to five per person, as well as a slight decrease in the number of surgeries required. However, the changes in more objective measurements such as surgery and prescription medication records point to the possibility that cannabis was quite beneficial for these individuals. It should be noted that individual responses can vary. You should discuss your specific situation with your physician and pharmacist prior to stopping any medication you take for a chronic condition. After this time, all the patients had smoked the full 50 g, and they saw improvements in their health. The subjects experienced significant improvement in pain, health perception, depression, social functioning, and ability to work. They also had an average weight gain of 4. These researchers support the idea that the benefits were the result of cannabinoids having anti-inflammatory, anti-motility, and analgesic effects. With only 13 participants, this study is too small to come to generalizations about most people, but it does show that cannabis might be effective for some individuals with IBD. However, the fact that the subjects knew they were taking the therapy may also have had an impact on their perception of improvement. It might be limited only to pain relief and increased appetite, but it might also help by reducing inflammation. We need more research on the topic before we can know for sure how cannabis affects IBD. While most research on cannabis and the gastrointestinal tract focuses on IBD, it might be helpful for individuals with other digestive illnesses. For instance, it seems to universally be effective at reducing abdominal pain. It can be especially useful for individuals taking opioid medications for abdominal pain, as research shows that cannabis helps patients cut down on or eliminate their need for opioids and provides a treatment with fewer side effects. Cannabis also helps individuals who have a difficult time eating enough by increasing appetite and it can help reduce diarrhea and nausea. There is quite a bit of evidence for many of these symptoms, so if you think cannabis might be useful for you, please consult your healthcare team to discuss the benefits and risks associated with its use. While cannabis seems to provide many benefits, it does have its drawbacks and side effects. Short-term side effects those that only affect you while the cannabinoids are in your body at higher levels can include short-term memory impairment, diminished motor skills, decreased reaction times, fatigue, anxiety, panic, increased heart rate, increased or decreased blood pressure, and dry mouth. These effects can make activities such as driving and operating large machinery dangerous, so avoid cannabis before any activity that requires quick thinking and sharp reflexes. Long-term side effects those that affect you after consistent cannabis use can include depression, anxiety, and dependence on or addiction to cannabis products. If you typically consume cannabis by smoking it, other long-term effects, including chronic cough, bronchitis, and lung infections, can also occur. You can avoid these effects by choosing other methods of administration, such as vaporization, ingestible oils, oral sprays, and capsules. In some cases, long-term cannabis use can cause a disorder called cannabinoid hyperemesis syndrome. Its symptoms include nausea, vomiting, and colicky abdominal pain that you can relieve temporarily by taking hot showers, or permanently by ceasing all cannabis use. Abrupt discontinuation of cannabis may cause withdrawal effects and the best method of stopping cannabis should be discussed with your healthcare team. In addition, there are certain individuals who should avoid cannabis products, whether recreational or medicinal. Individuals with a personal or familial history of mental illness should also try to avoid cannabis, as it might exacerbate certain mental health syndromes. However, in children with severe seizure disorders epilepsy , a neurologist or other neuro-specialist might recommend cannabis products that are high in CBD to reduce seizure frequency and severity. This is usually only done in cases where the epilepsy is so severe that getting the seizures under control is more important than any potential risks from cannabis and other pharmacological treatment options have been tried or considered. Cannabis can also interfere with your ability to make sound decisions and judgements, so it is important to avoid risky behaviour to prevent accidents. One other thing to be aware of is the interaction potential between cannabis and other medications, which can lead to increased or decreased blood-levels of various medications. Make sure to speak with your physician, pharmacist, or nurse practitioner if you are taking other medications along with cannabis. Overall, medical cannabis is generally safe. It has virtually no overdose potential, so it does not lead to overdose death, but it is important to be aware of the potential side effects and complications, which might lead to fatal accidents in individuals who behave recklessly while using cannabis. Going forward, with legal recreational cannabis in play, it is important to ensure that individuals who require medical cannabis still have ready access to it through their healthcare teams. This should include consultations on dosing and strain type with a physician, pharmacist, or nurse practitioner trained in medical cannabis. Individuals who require cannabis as a treatment for their disease or disorder should not have to guess at what to buy from a recreational dispensary. If you wish to try using medical cannabis, speak with your healthcare practitioner. You can get a medical authorization document from healthcare professionals, which you can use to purchase cannabis through licenced medical sellers rather than recreational sellers. While some physicians are wary about prescribing cannabis, many are comfortable doing so. When using medical cannabis, always follow the advice and recommendations of your healthcare team and make sure cannabis use aligns with the other prescription treatments you are taking. According to some research, men and women use and experience cannabis quite differently. Men are generally more likely to use and be dependent on cannabis, 15 and they are more likely to report positive effects such as improved memory and increased musicality. In addition, women are more likely to use cannabis medicinally in order to treat irritable bowel syndrome, migraines, anxiety, loss of appetite, and nausea. Cannabis was the first product to be traded online. Bhang is a drink that people in India have consumed in some variation for thousands of years, often during a Hindu spring festival called Holi. Making bhang involves taking leaves and buds from the cannabis plant, grinding them up, and combining them with milk, sugar, nuts, spices, and rose water, cooking until combined, straining, and then chilling it to serve as a cold beverage. Historically, canvas was made from sturdy hemp fibres. In what is now China, archeologists uncovered the grave site of a man who died 2, years previously, and was buried along with 28 ounces of cannabis. While rare, some individuals are allergic to cannabis. Symptoms are similar to other allergies, and can include itchy and watery eyes, sneezing, runny nose, rashes, hives, wheezing, shortness of breath, and even anaphylaxis. Medical Cannabis Cannabis is a genus of plant that contains three varieties: Cannabis indica , Cannabis sativa , and Cannabis ruderalis. Cannabis Animation Video. Sorry, your browser doesn't support embedded videos. Cannabis Presentation Video. History of Cannabis. Cannabinoids and the Endocannabinoid System. One Plant, Many Uses When we develop cannabis to grow tall and strong with thick fibrous stalks that are low in THC we typically refer to it as hemp. Medicinal Uses of Cannabis. Cannabis and IBD. Cannabis and Other GI Symptoms. Negative Effects of Cannabis. What would be the best method of administration for my needs? Will cannabis interact with any of the medications I am currently taking? Do I have any insurance coverage options for medical cannabis? What side effects are likely, and what can I do to reduce this? Are there potential interactions between cannabis and my other illnesses? If I choose to use medical cannabis, what steps do I need to take to begin and continue therapy? Accessing Medical Cannabis. Did You Know? Stockwell GA. Indian Hemp Cannabis indica seu sativa. Scientific American. Supplement No. July 2, Accessed Alger BE. Getting high on the endocannabinoid system. Ahmed W et al. Gastroenterology and Hepatology. Corey-Bloom J et al. Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. Canadian Medical Association Journal. Ware MA et al. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Ostadhadi S et al. Therapeutic potential of cannabinoids in counteracting chemotherapy-induced adverse effects: an exploratory review. Phytotherapy Research. Szaflarski JP et al. Cannabis, cannabidiol, and epilepsy—from receptors to clinical response. Epilepsy and Behavior. Naftali T et al. The Israel Medical Association Journal. Lahat A et al. Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study. Keyhani S et al. Annals of Internal Medicine. Nielsen S et al. Borgelt LM et al. The pharmacologic and clinical effects of medical cannabis. Kim D et al. Inverse association of marijuana use with nonalcoholic fatty liver disease among adults in the United States. PLoS One. Government of Canada. Health Effects of Cannabis. Canadian Centre on Substance Use and Addiction. August Canadian Drug Summary. Cuttler C et al. Cannabis and Cannabinoid Research. Russo EB et al. Phytochemical and genetic analyses of ancient cannabis from Central Asia. Journal of Experimental Botany. Jiang H et al. Economic Botany.
Treatment and Medication
Colon buying Cannabis
Join us for a three-day experience where patients, caregivers, and advocates unite against colorectal cancer. You don't have to do this alone. Call our toll-free helpline: Marijuana has gone by many names over the years, including weed, pot, bud, ganja, and Mary Jane, to name a few. It comes from the dried flowers of the Cannabis sativa plant and has been used for its therapeutic effects since around BC. Marijuana contains more than chemical compounds known as cannabinoids. It is possible to consume CBD — also known as hemp — as a single compound. While it is recommended to consult your healthcare provider about your marijuana usage, complications may arise for cancer patients seeking medical advice. This is largely due to a lack of training and a need for more clinical studies. Marijuana is considered medical when it is used to treat or relieve a severe and persisting health condition and prescribed by a licensed doctor in states where it is legal. Each state has its own qualifications, so it is important to check the laws and regulations before pursuing this therapy. Just like any healthcare option, marijuana is not free from side effects. The most common ones include:. It is best to start with low amounts of THC and go slow when determining if medical marijuana is right for you. Additionally, you should notify your healthcare provider, as it could have an impact on your overall treatment plan or interfere with certain medications. Despite the risk of side effects, many cancer patients are turning to medical marijuana for symptom relief. Cancer medication, radiation, and chemotherapy are known to cause nausea, neuropathy, vomiting, and pain. Medical marijuana has proven to be an effective tool in addressing many of these complications. In addition, the National Cancer Institute , American Cancer Society , and CDC have all noted several studies that show cannabis to be effective at treating nausea and vomiting, pain, neuropathy, anxiety, and sleep. Anecdotal evidence is also on the rise. In , a study was released that followed 2, cancer patients treated with medical marijuana between the years and An astounding Despite legalization in 37 states and compelling evidence that supports the positive effects of medical marijuana, many barriers still exist. The main challenges researchers face today include:. To overcome these barriers, it is important to continue having conversations about how and why it is necessary to support medical marijuana research, especially in oncology patients. Organizations must work together to end the stigma and put pressure on restrictive federal policies that make research increasingly difficult. Despite the need for more research, cancer patients are still using this therapy with reported improved outcomes. Not all marijuana and THC is created equal. I would choose THC over pain medications any day. First, I was trying a combination of various opioids to control my pain with little luck. They helped alleviate my pain, nausea, and reduced some of my inflammation. I did notify my team of my pain management decision. THC worked wonders for me and I would choose it again. Sometimes, patients prefer to remain entirely anonymous. I used it to keep nausea at bay and increase my appetite during chemo. After my surgery, I used it for pain relief and it helped me more than the narcotics they prescribed. As a survivor, I now use it for abdominal pain that begins after eating and to assist in falling asleep at night. The Colorectal Cancer Alliance seeks to end this disease in our lifetime and recognizes the need for unique solutions to complex problems. The Alliance looks forward to the promise that new marijuana research brings for colorectal cancer patients. She tried to control what she could. And, critically, she received biomarker testing. Register for AllyCon Register Now. The Basics The basics: what is colorectal cancer? Colorectal cancer symptoms Facts and statistics Stages of colorectal cancer Health equity Glossary. Get screened at 45 How to talk to your doctor about screening Colonoscopy prep tips Screening methods Prevention. Treatment: what are your options? For you. Research: our efforts to end colon and rectal cancers. How we fund research Research investments Research library. Get involved: help us end colorectal cancer. Managing a Diagnosis Patient and Caregiver Support. When will I lose my hair during colorectal cancer treatment? Chemotherapy often leads to temporary hair loss. Last updated Jul 1, Last updated Apr 21, Last updated May 23,
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