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Chebib I, Jo VY.
Chebib I, et al.
Cancer Cytopathol. 2016 May;124(5):350-61. doi: 10.1002/cncy.21685. Epub 2016 Jan 22.
Cancer Cytopathol. 2016.

PMID: 26800124








Pelmus M, Guillou L, Hostein I, Sierankowski G, Lussan C, Coindre JM.
Pelmus M, et al.
Am J Surg Pathol. 2002 Nov;26(11):1434-40. doi: 10.1097/00000478-200211000-00005.
Am J Surg Pathol. 2002.

PMID: 12409719








Tang S, Dodd LG.
Tang S, et al.
Diagn Cytopathol. 2018 Nov;46(11):958-963. doi: 10.1002/dc.24027. Epub 2018 Oct 24.
Diagn Cytopathol. 2018.

PMID: 30353686








Xiao GY, Pan BC, Tian XY, Li Y, Li B, Li Z.
Xiao GY, et al.
Brain Tumor Pathol. 2014 Jan;31(1):68-75. doi: 10.1007/s10014-012-0126-9. Epub 2012 Dec 8.
Brain Tumor Pathol. 2014.

PMID: 23223956


Review.





Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P.
Han LM, et al.
Acta Cytol. 2021 Jul 2:1-11. doi: 10.1159/000516497. Online ahead of print.
Acta Cytol. 2021.

PMID: 34218227


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Synovial sarcoma is a translocation associated soft tissue malignancy frequently affecting young adults. The classic translocation is t(X;18)(p11.2;q11.2): SS18-SSX1/2/4 fusion. Synovial sarcoma tends to favor the distal extremities but can also arise in other locations. To date, no case of primary synovial sarcoma of the uterine cervix has been reported. We report a 42-yr-old woman with no prior history who presented to clinic with vaginal spotting for 3 mo and was found to have a large mass in the uterine cervix. The mass was evacuated from the vagina and sent for pathologic diagnosis. Sections showed proliferation of monotonous spindle cells with scant eosinophilic cytoplasm, round to slightly irregular nuclei, variable nucleoli and frequent mitosis in a background of delicate capillary and occasional thick-walled vessels. No malignant epithelium was identified in the entire specimen. On immunohistochemical workup tumor cells were negative for pan cytokeratin, OSCAR, EMA, chromogranin, S100, SMA, desmin, myogenin, WT1, CD117, CD34, and BRG1. CD45 was positive in a few inflammatory cells. Cyclin D1 showed partial weak to moderate nuclear reactivity. CD99 demonstrated strong diffuse membranous reactivity and BCL-2 showed strong cytoplasmic staining in 60% of tumor cells. Florescence in situ hybridization results for EWSR1, BCOR, and CIC gene rearrangements were negative, however, florescence in situ hybridization results for SS18 (SYT) (18q11) gene rearrangement was positive. A diagnosis of monophasic synovial sarcoma was rendered. We review the differential diagnoses of tumors with similar morphology and discuss the diagnostic process. With this case report it is imperative to include synovial sarcoma in differential diagnosis list of sarcomas of uterus and cervix.


Copyright © 2020 by the International Society of Gynecological Pathologists.

The authors declare no conflict of interest.

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From Wikipedia, the free encyclopedia
For other uses, see Cervix (disambiguation) .
The human female reproductive system . The cervix is the lower narrower portion of the uterus .
The squamocolumnar junction of the cervix: The ectocervix, with its stratified squamous epithelium, is visible on the left. Simple columnar epithelium, typical of the endocervix, is visible on the right. A layer of connective tissue is visible under both types of epithelium.
Transformation zone types: [16] Type 1: Completely ectocervical Type 2: Endocervical component but fully visible Type 3: Endocervical component, not fully visible


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^ Jump up to: a b Facesitting New Russia Video
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Primary Synovial Sarcoma of the Uterine Cervix : First Case ...
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