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Background: The relationship between substance use disorders and psychiatric pathology is still an open question. The main aim of the present study was to verify whether the five psychopathological dimensions identified through the SCL tool in a previous study carried out on patients with heroin addiction entering an outpatient opioid agonist treatment OAT were also observable in those entering a residential treatment community TC. Further aims were to look at differences in the psychopathological profiles of patients entering a TC versus an OAT treatment and at the correlation between gender and the observed psychopathology. Methods: A confirmatory factor analysis was performed on the results of SCL filled by 1, patients with heroin dependence entering TC treatment. It replicates the extraction method previously used on 1, OAT patients with heroin addiction by using a principal component factor analysis PCA. The association between the kind of treatment received TC or OAT , gender, and the psychopathological dimensions was assessed through logistic regression and general linear model GLM analysis. Results: The PCA carried out on the SCL results of patients entering a TC yielded a five-factor solution, confirming the same dimensions observed in patients entering an OAT: 'worthlessness and being trapped', 'somatization', 'sensitivity-psychoticism', 'panic anxiety', and 'violence-suicide'. The logistic regression analysis showed a statistically significant association between 'somatization' and 'violence-suicide' severity score and OAT. GLM analysis showed that psychopathological factorial scores for 'worthlessness-being trapped', 'somatic symptoms', and 'panic anxiety' dimensions were more severe in OAT vs TC male patients and in TC vs OAT female ones. The five dimensions did not differ in OAT males vs females. It also shows a correlation between the dominant psychopathological subgroup and the assignment to TC versus OAT. Further research is needed to clarify the differences between the five psychopathological subgroups and their determinants. Abstract Background: The relationship between substance use disorders and psychiatric pathology is still an open question.
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