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Join us for a three-day experience where patients, caregivers, and advocates unite against colorectal cancer. You don't have to do this alone. Call our toll-free helpline: If there is one common theme in all of the literature and scientific papers, it is that cannabis and cannabinoids enhance the benefits of conventional treatment for side effect management. For cancer patients, this is most notable in chemotherapy-induced nausea and vomiting as well as pain management. In an article published in the Journal of the American Medical Association Oncology, authors reviewed the literature surrounding the treatment of cancer with cannabis. While the majority of the data came from animal trials, results were positive. For example, tetrahydrocannabinol THC slowed lung cancer tumor growth in mice. Although the information is promising in animals, further research in human clinical trials is needed. While there have been a few clinical trials in humans studying the use of cannabis as a cancer treatment, the results are either inconclusive or still pending. Some of these clinical trials include:. A clinical trial in humans with malignant brain cancer glioblastoma multiforme aka GBM showed tumor shrinkage in two out of nine patients when THC was administered directly into the tumor. Unfortunately, even though the tumors shrunk, the patients did not live longer. Two other clinical trials in Israel are studying the treatment of GBM with cannabis in patients who have failed all other treatments. Another clinical trial in Israel is studying cannabinol as a single agent in patients with solid tumors who have failed all other therapies. Impact on treatment: Regardless of whether or not marijuana is legal in your state, it is important to tell your doctor if and how you use marijuana, either recreationally or medically, and the frequency of your use. Marijuana interferes with the metabolism of many drugs, including chemotherapeutic agents and herbal supplements. Marijuana is metabolized in the liver as are many chemotherapy agents. Side effects: Evaluate whether the side effects and adverse effects of medical marijuana outweigh the perceived benefits. Medical marijuana, along with many FDA-approved drugs and alcohol, all have adverse effects. It is important to weigh the pros and cons. Not a cure-all: If you choose to use medical marijuana for chemotherapy-induced nausea and vomiting, it is best to use it along with standard treatments. False hope: Cannabis in any form, including oil, does not cure cancer. Additionally, there is no evidence that it prevents cancer. The oil can actually be toxic due to the high concentrations of chemicals. If you are going to use medical marijuana, do not think of it as a cure-all. No quality control: Just because it is natural does not mean it is safe. Medical marijuana is not guaranteed to have the compounds that may be specified because there is no regulatory body monitoring medical marijuana manufacturing. Approximately nine percent of adults who use marijuana become addicted. If you or someone you love is considering medical marijuana, do your research, look at the references we provide, talk with others, and speak with your doctor. If you are in need of support, please contact our free Helpline at Learn about The Cancer Promise initiative and how political candidates can pledge to support cancer research, prevention, and care policies. Make your voice heard this election. The treatment option is for patients with KRASG12C-mutated locally advanced or metastatic colorectal cancer CRC who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. Register for AllyCon Register Now. The Basics The basics: what is colorectal cancer? Colorectal cancer symptoms Facts and statistics Stages of colorectal cancer Health equity Glossary. Get screened at 45 How to talk to your doctor about screening Colonoscopy prep tips Screening methods Prevention. Treatment: what are your options? For you. Research: our efforts to end colon and rectal cancers. How we fund research Research investments Research library. Get involved: help us end colorectal cancer. Research Managing a Diagnosis Treatment. Be heard this November: The Cancer Promise Learn about The Cancer Promise initiative and how political candidates can pledge to support cancer research, prevention, and care policies. Last updated Sep 25, When will I lose my hair during colorectal cancer treatment? Chemotherapy often leads to temporary hair loss. Last updated Jul 1, Krazati approved for previously treated KRASG12C colorectal cancer The treatment option is for patients with KRASG12C-mutated locally advanced or metastatic colorectal cancer CRC who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. Last updated Jun 25,

Treatment and Medication

Buying weed Colon

People with inflammatory bowel disease may be considering using cannabis for a variety of reasons. There is a desire for an alternative or complementary treatment to existing traditional therapies. Many people living with IBD have reported relief of symptoms like pain, nausea, diarrhea, low appetite, and an improvement in overall mood when using cannabis. Cannabis products are available in many different forms. Cannabis can be smoked, inhaled, ingested or made into oils, capsules, and edibles. Most people using cannabis for medicinal purposes consume it as an oil or vapor. The method of consumption can influence the effects of cannabis, which is explained in more detail below under The Effects of Cannabis. Traditionally, cannabis has been smoked as a joint. Smoking carries with it many of the risks of smoking tobacco, so health professionals have advised against smoking cannabis. Cannabis smoke is filled with many of the same chemicals as tobacco and can be harmful to the lungs. Cannabis contains a variety of compounds called cannabinoids which are the active ingredients in the plant there are over 70 cannabinoids reported so far. The human body has an Endocannabinoid System ECS which regulates different functions such as pain, appetite, mood, and stress response. The ECS is comprised of endocannabinoids natural cannabinoids produced by our bodies that stimulate our cannabinoid receptors. They are found in different parts of the body including the brain, liver, nervous system, and especially, the gastrointestinal tract. When people consume cannabis, the cannabinoids THC, CBD and others mimic those found in the body and activate the same receptors. In the gut, these receptors trigger certain responses such as regulating inflammation, pain, nausea, satiety, vomiting, and possibly, altering gut barrier function the leakiness of the gut. To take effect, the cannabinoids bind to endocannabinoid receptors on the surface of different cells. Once locked in, some of the effects that can take place have been reported to improve symptoms in patients with inflammatory bowel disease. Different strains of cannabis have different combinations of cannabinoids. CBD and THC are the major active ingredients in the cannabis plant, but when cannabis is consumed, users get the effect of a number of products in the plant. The two most common strains of cannabis are called indica and sativa. Indica is said to have a more relaxing effect while sativa has a more energizing effect. There are also hybrid strains that combine both. Different methods of consumption will alter how long the effects of cannabis will last. Intensity how strong the effects are is highest with inhalation smoking or vaporizing but the duration is shorter. If you smoke or vaporize cannabis, the effects are very rapid and can usually be felt within a few minutes, usually peaking within 30 minutes to an hour. Effects can last between two and four hours. Note that edible cannabis products are only legal and available in some Canadian provinces. Cannabis is relatively harmless in low to moderate amounts. But using cannabis can cause some short-term side effects including:. Physical impairments such as short-term memory or concentration loss, dizziness, drowsiness, fatigue, headache, disorientation, confusion, and feeling faint. There is little data available on the long-term dangers of cannabis use so we advise to use caution. Increased risk of mental health problems such as the development of depression, anxiety, psychosis, and schizophrenia. Physical problems that can affect the respiratory system like symptoms of chronic bronchitis when smoking. Potential risk of dependency or addiction. A small percentage of cannabis users develop a dependence, which is much lower than other substance use such as alcohol, tobacco, and other drugs. Can lead to withdrawal symptoms if stopped, such as anger, aggression, nightmares, insomnia, headaches, anxiety, irritability, depression, cravings, decreased appetite, stomach pain, chills, and sweating. Unlike most other drugs, there have been no deaths attributed to cannabis alone. Someone would have to consume an impossibly high amount of cannabis in order to overdose. A limited number of studies have reported improvement with smoked cannabis. Heavy cannabis use is associated with more severe GI disease, but it is relatively harmless in low to moderate amounts. Heavy cannabis use is associated with cannabis hyperemesis syndrome, a condition involving nausea, low appetite, vomiting and abdominal pain. Symptoms resolve when people stop using cannabis. It is advised that those under 21 years old do not use cannabis since their brain is not fully developed. Cannabis use can impact brain development, specifically the pre-frontal cortex, which is the area of the brain that is last to develop. This area is responsible for skills like thinking ahead and weighing risks and harms about decisions we make. Certain mental health issues are also at an increased risk with cannabis consumption during this time. There are some suggestions that long term cannabis use may affect sperm quality by decreasing the sperm count, concentration and motility. Early research suggests cannabis may delay or inhibit ovulation and lower sperm counts but is based on self-reported use. On the other hand, a recent study suggests cannabis may not interfere with trying to conceive. Cannabis use during pregnancy can negatively impact the behavioural and cognitive development of the baby including resulting in low birth weight, preterm labour, and stillbirth. The Society of Obstetricians and Gynecologists of Canada recommends to avoid cannabis during pregnancy. Can cannabis improve the quality of life for people suffering from gastrointestinal disorders? Research is in its early stages, but patients have reported some therapeutic effects in the management of abdominal pain, nausea, diarrhea, and improvements in sleep, appetite and quality of life. Observational studies suggest patients use cannabis to relieve symptoms associated with IBD. In observational studies, the investigator simply observes participants and records what happens without intervening. Clinical studies, on the other hand, are controlled and randomized to achieve unbiased results. This type of research aims to answer a specific question. There are some flaws in human studies that examine cannabis and the management of IBD including:. Recall bias is present. Observational studies in patients with IBD are still limited, but early research suggests patients use cannabis to relieve symptoms associated with IBD. The number one reason patients use cannabis is to control abdominal pain. Patients with IBD also reported improvements in joint pain, abdominal pain and cramping after using cannabis. Improvements in sleep, reduced diarrhea, nausea and appetite were also reported after using cannabis. It is not yet known what the best type or strain of cannabis is for symptom management in IBD. There are some suggestions that the indica strain is more effective at reducing pain, controlling nausea, and helping with sleep but there is little evidence on the different benefits of different strains. Cannabis may mask inflammation because the symptoms have improved, but there is little evidence to support that cannabis plays an anti-inflammatory role. There is no evidence that cannabis positively alters the disease course. There is also no evidence to demonstrate any benefit of cannabis in gut motility disorders. Gut motility is related to the movement of the digestive system. It is the expansion and contraction of the muscles in the GI tract. There is little evidence to support the use of cannabis for treatment in GI disease but some suggestion that it improves quality of life and relieve some symptoms. Cannabis cannot cure IBD. If you are using cannabis in combination with other medications, discuss this directly with your health care provider. To find out more about research studies that investigates the effectiveness of cannabis for IBD management, click on the articles below:. Dosing for medical cannabis is highly individualized. There are no defined doses of cannabis for specific medical conditions, though current information suggests up to 3 grams daily is common for experienced users. When used individually, THC was more effective. If you have never used cannabis before, do so with someone you trust close by in case you experience adverse effects. Start slow and gradual for example 1 mg of THC and wait 30 minutes before taking more puffs or inhalations to gauge the strength and effects taking place. Increasing your dose should be done slowly and as needed. There is not a lot of data on the best dose or optimal timing. Start with a low amount of cannabis with a small quantity of active ingredients especially low amounts of THC to avoid major psychiatric effects. Remember to keep your health care providers informed of your dosing patterns. Since cannabis has no effect on inflammation, it does not replace conventional medical therapy. Be open and upfront with your healthcare provider. It also helpful to log or note your dosing and symptoms and report this information to the health care provider. When discussing your cannabis use with family, be prepared to answer questions honestly and keep the conversation open and ongoing. Explain the benefits of cannabis for managing your symptoms and explain that you are consulting with your healthcare provider throughout the process. With children, you may want to gauge how much they know about cannabis and how they feel about it. Explain the facts, focusing on medical benefits, physical side effects, safety, legal implications like cannabis and driving and any risks to be aware of. Remember to reflect on your substance use and coping strategies so you can better address these conversations with your children. Build trust so they are able to come to you with questions and encourage them to share their own experiences. Medical cannabis became legal in Canada in Recreational cannabis, on the other hand, recently became legal in October under the Cannabis Act. The Act helps set rules around production, distribution, sale and possession of cannabis. It outlines safety and quality requirements, including restricting access to youth and specifying criminal penalties for those who break the law. Cannabis is legal for adults 18 or 19 years old, depending on the province or territory. Here are some important things to note under this Act:. It is legal to consume in authorized locations only. Authorized locations differ between provinces and territories. As a general rule, smoking in your home is okay if you rent, check with your landlord. Smoking in most public greenspaces is okay. There are criminal penalties for offences such as driving impaired or crossing international borders with cannabis. Edible cannabis products and cannabis extracts are still illegal to purchase in some provinces, though you can make your own. The side effects of cannabis use can impair driving. Driving while impaired by drugs including cannabis is illegal. Law enforcement are trained to detect drug-impaired drivers. Repercussions of driving impaired can include fines, confiscations and charges. Talk with your health care provider about the timing of your cannabis use to ensure safety on the road. Rules regarding driving with cannabis differ between provinces. Here are some general recommendations:. Do not cross international borders with cannabis - no exceptions. It is illegal to travel outside of Canada with cannabis, even to and from countries where cannabis is legal. In rare circumstances, Health Canada may authorize a person to bring cannabis across international borders for medical purposes. Learn more about cannabis and international travel. Flying with cannabis within Canada is legal. Carrying cannabis oil in a carry-on luggage must follow the liquid restriction of ml or less. Under the Canadian Human Rights Act, employers are obligated to accommodate those with medical cannabis authorizations, to the point of undue hardship. Medical cannabis must be treated like any other prescription medication. To learn more about cannabis in Canadian workplaces, click here. Although now legal, consuming cannabis is prohibited at schools, on school grounds, in public areas within 20 metres of these grounds, and in child care centres including home care, in accordance with the Smoke-Free Ontario Act. This Act also applies to tobacco and electronic cigarettes. Those who require cannabis for medical purposes are permitted to carry it on school property. Students and staff can use medical cannabis on school property in non-smoking and non-vaping form for example, cannabis oils and capsules. School boards are responsible for developing policies pertaining to the administration and storage of medications in schools. Cannabis can be purchased directly from a federally licensed seller or authorized provincial outlet, or you may grow your own. If you would like to access cannabis for medical use, speak with your health care provider to discuss if cannabis is right for you. With this document, you can register with a licensed producer of your choice by contacting them directly or visiting their website to fill out a registration form. You can also register to purchase the materials to produce your own cannabis or have another person produce it on your behalf. Personal storage limits under the Cannabis Act indicate you are allowed to possess either a a day supply of what your healthcare provider has prescribed or b grams -- whichever comes first. Be prepared to show law enforcement, if requested, that you are authorized to carry more than the 30 grams of cannabis for recreational use. You can switch licensed producers at any time by cancelling your registration with your current producer and obtaining another medical document from your healthcare provider to register with your new producer. The packaging would also include the standardized cannabis symbol and mandatory health warnings. There is currently no public insurance coverage for medical cannabis. Since medical cannabis does not yet have a drug identification number DIN , provincial health insurance programs, such as OHIP in Ontario, do not cover it. It is not included on the drug formularies and did not go through the formal Health Canada process to become an approved drug. Your workplace benefits plan may cover medical cannabis for certain health conditions through a private insurance plan. Health spending accounts typically consider medical cannabis as an eligible expense. Contact your Human Resources department to find out if your workplace benefits covers medical cannabis. Veterans Affairs Canada has a reimbursement policy for medical cannabis purchased from a licensed producer, up to three grams per day. Watch the video below to learn from a gastroenterologist about cannabis use to manage symptoms of Crohn's and colitis. Speaker: Dr. Watch the video below to learn more from a gastroenterologist and expert about cannabinoids and the effects of cannabis on the mind and body. Keith Sharkey Ph. Yasmin Nasser MD Ph. We use cookies on this site to improve your browsing experience, as further explained in our Privacy Policy. Please click OK to signify your consent to our use of cookies. You can reject cookies by changing your browser settings. Medical Cannabis. What is cannabis? The cannabis plant is said to be one of the oldest agricultural crops. One strain of the plant, called hemp, has been used for industrial purposes to make food hemp seeds , paper, clothing, rope, insulation, biofuel and more over the ages. Using cannabis as a medicine dates back to the ancient world, where it was used to heal wounds and soothe pain. Recently, the medical potential of cannabis has been gaining interest for its effects on different symptoms. Medical cannabis became legal in Canada in to treat a number of conditions. Cannabis has also been used recreationally for its psychoactive properties. There is no real difference between medical and recreational cannabis. It is the intent that is different, but the drug is the same. Sometimes there is an overlap. If you intend to use cannabis for its medicinal properties, you may look for features of the plant that make you feel better and give your body relief. Typically, medical cannabis contains a higher concentration of CBD. If you are using cannabis for recreational purposes, you may be concerned with the amount of THC in the plant and focus on the method of consumption and the timing of consumption to suit your activities. Medical cannabis is prescribed by a healthcare provider. The patient would get a medical authorization to purchase from a licensed seller. More about accessing cannabis is explained later in this section under How to Access Cannabis. The legalization of cannabis may increase opportunities for clinical research on the role of cannabis in the management of inflammatory bowel disease. There is a perception of cannabis as natural and harmless. There is a possible benefit as an alternative to opioids and other drugs. Smoking Traditionally, cannabis has been smoked as a joint. Vapourization vape Vaporization has become a popular way to consume cannabis, both medically and recreationally. Vaping involves heating cannabis into a vapour and inhaling it through a mouthpiece. Oil and edibles Edibles such as a brownie or gummy bear can also be consumed, though these are only legal in some provinces across Canada. Edibles are more risky for a number of reasons. If the ingredients are not measured correctly, homemade edibles can more potent than anticipated. In addition, when cannabis is swallowed, the effects take longer to onset. This can cause people to consume more cannabis than needed to get the desired effects and can lead to an overdose. Ingested cannabis also takes longer to clear from the body. Cannabinoids THC vs CBD Cannabis contains a variety of compounds called cannabinoids which are the active ingredients in the plant there are over 70 cannabinoids reported so far. THC may be the most recognized cannabinoid. It is also associated with some negative effects such as anxiety and irritability. It may also counter some of the negative symptoms associated with THC. The endocannabinoid system The human body has an Endocannabinoid System ECS which regulates different functions such as pain, appetite, mood, and stress response. Strains of cannabis Sativa vs Indica Different strains of cannabis have different combinations of cannabinoids. How long will the effects last? Short-term side effects Cannabis is relatively harmless in low to moderate amounts. But using cannabis can cause some short-term side effects including: Physical impairments such as short-term memory or concentration loss, dizziness, drowsiness, fatigue, headache, disorientation, confusion, and feeling faint Impaired motor skills and perception Increased anxiety, paranoia, suspiciousness, hallucinations Dry mouth and coughing Skin reactions Nausea, vomiting Fast heartbeat Adverse effects of long-term cannabis There is little data available on the long-term dangers of cannabis use so we advise to use caution. Impact on brain functions like memory, concentration, decision-making, and judgement Increased risk of mental health problems such as the development of depression, anxiety, psychosis, and schizophrenia Physical problems that can affect the respiratory system like symptoms of chronic bronchitis when smoking Potential risk of dependency or addiction. Can lead to withdrawal symptoms if stopped, such as anger, aggression, nightmares, insomnia, headaches, anxiety, irritability, depression, cravings, decreased appetite, stomach pain, chills, and sweating Unlike most other drugs, there have been no deaths attributed to cannabis alone. Cannabis Hyperemesis Syndrome Heavy cannabis use is associated with cannabis hyperemesis syndrome, a condition involving nausea, low appetite, vomiting and abdominal pain. Cannabis and young people teens It is advised that those under 21 years old do not use cannabis since their brain is not fully developed. Fertility and pregnancy There are some suggestions that long term cannabis use may affect sperm quality by decreasing the sperm count, concentration and motility. There are some flaws in human studies that examine cannabis and the management of IBD including: Cannabis use is often underreported. There are no objective parameters or measurements to show symptom improvements. Small sample sizes, short research timeframes, and little or no follow up can affect results. Symptom relief and quality of life Observational studies in patients with IBD are still limited, but early research suggests patients use cannabis to relieve symptoms associated with IBD. Best strain for symptom relief It is not yet known what the best type or strain of cannabis is for symptom management in IBD. Cannabis and gut inflammation Cannabis may mask inflammation because the symptoms have improved, but there is little evidence to support that cannabis plays an anti-inflammatory role. Talking with health care providers Since cannabis has no effect on inflammation, it does not replace conventional medical therapy. Come prepared to answer these questions: Which symptoms does cannabis help you manage? How much are you consuming in grams, if possible? How are you consuming it smoking, vaping, oil, etc. What type of strain are you using? What has your experience been like? Talking with family and kids When discussing your cannabis use with family, be prepared to answer questions honestly and keep the conversation open and ongoing. The Cannabis Act Medical cannabis became legal in Canada in Here are some important things to note under this Act: It is legal to possess up to 30 grams of cannabis at a time. It is legal to grow up to four cannabis plants per household for personal use. Legal cannabis includes fresh or dried cannabis, cannabis oil, and seeds and plants. Cannabis and driving The side effects of cannabis use can impair driving. Here are some general recommendations: Keep receipts to show cannabis was purchased at an authorized outlet. Keep cannabis in its original, sealed packages. Travel with cannabis in the trunk, out of reach. Transport it from point A to point B. Travelling with cannabis Do not cross international borders with cannabis - no exceptions. Cannabis use in the workplace Under the Canadian Human Rights Act, employers are obligated to accommodate those with medical cannabis authorizations, to the point of undue hardship. Cannabis in post-secondary school Although now legal, consuming cannabis is prohibited at schools, on school grounds, in public areas within 20 metres of these grounds, and in child care centres including home care, in accordance with the Smoke-Free Ontario Act. Recreational and medical cannabis Cannabis can be purchased directly from a federally licensed seller or authorized provincial outlet, or you may grow your own. Insurance Coverage There is currently no public insurance coverage for medical cannabis. Video: Cannabis and Inflammatory Bowel Disease Watch the video below to learn more from a gastroenterologist and expert about cannabinoids and the effects of cannabis on the mind and body. Speakers: Dr. Next Drug Coverage and Financial Support. Goals of Therapy. Sulfasalazine and 5-Aminosalicylates 5-ASA. JAK inhibitors. S1P receptor modulators. Enteral Nutrition EEN. Drug Coverage and Financial Support. Additional Resources. Join us at Gutsy Walk! MyGut App. Volunteer With Us. Create A Fundraiser. Advocate For Change.

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