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Aoki, M. Macleod, P. Paggiaro, O. Carewicz, A. El Sawy, C. Wat, M. Griffiths, E. Waalberg, P. Our objective was to evaluate the benefit of early treatment of influenza illness using oral oseltamivir. This open-label, multicentre international study investigated the relationship between the interval from illness onset to first dose time-to-treatment and illness duration in the intent-to-treat infected population using accelerated failure time AFT modelling. Initiation of therapy within the first 12 h after fever onset reduced the total median illness duration by Intermediate interventions reduced the illness proportionately compared with 48 h. In addition, the earlier administration of oseltamivir further reduced the duration of fever, severity of symptoms and the times to return to baseline activity and health scores. Oseltamivir was well tolerated. The most common adverse events were nausea and vomiting, which were transient and generally occurred only with first dosing. When oseltamivir was taken with food, the tolerability was enhanced. The overall discontinuation rate was low 1. In conclusion, the IMPACT study demonstrated that earlier initiation of oral oseltamivir therapy increased its therapeutic effects, which were seen at every time point of intervention and were progressive. Thus, early presentation, diagnosis and treatment of patients with influenza maximized the benefits of oseltamivir therapy. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. Enter your library card number to sign in. 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To purchase short-term access, please sign in to your personal account above. Don't already have a personal account? Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Advertisement intended for healthcare professionals. Sign in through your institution. BSAC Journals. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Journal Article. Early administration of oral oseltamivir increases the benefits of influenza treatment Get access. Aoki , F. Oxford Academic. Google Scholar. El Sawy. Cite Cite F. Select Format Select format. Permissions Icon Permissions. Abstract Our objective was to evaluate the benefit of early treatment of influenza illness using oral oseltamivir. Issue Section:. You do not currently have access to this article. Download all slides. 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