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Seyedmojtaba Seyedmousavi, Roger J. Melchers, Antonius J. Rijs, Paul E. Verweij, Johan W. Azole resistance is an emerging problem in the treatment of Aspergillus fumigatus infections. Combination therapy may be an alternative approach to improve therapeutic outcome in azole-resistant invasive aspergillosis IA. The in vivo efficacy of voriconazole and anidulafungin was investigated in a non-neutropenic murine model of IA using voriconazole-susceptible and voriconazole-resistant A. In vitro and in vivo drug interactions were analysed by non-parametric Bliss independence and non-linear regression analysis. Synergistic interaction between voriconazole and anidulafungin against the voriconazole-susceptible isolate AZN was observed in vitro and in vivo. For this isolate, additivity, but not synergy, was observed in vivo. Combination of voriconazole and anidulafungin was synergistic in voriconazole-susceptible IA, but additive in voriconazole-resistant IA. There is a clear benefit of combining voriconazole and anidulafungin, but the reduced effect of combination therapy in azole-resistant IA raises some concern. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. Enter your library card number to sign in. If you cannot sign in, please contact your librarian. Many societies offer single sign-on between the society website and Oxford Academic. If you do not have a society account or have forgotten your username or password, please contact your society. 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Buying cocaine online in Kapelle aan den Eissel

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Buying cocaine online in Kapelle aan den Eissel