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Some of the pills looked just like antibiotics. Others were unlabeled white tablets. Several mimicked well-known American pills, and a few came in sealed bottles. Earlier this year, The Times found that pharmacies in several northwestern Mexico cities were selling counterfeit pills over the counter, passing off powerful methamphetamine as Adderall and deadly fentanyl as Percocet and other opioid painkillers. But four more months of investigation showed the problem is much broader than previously understood. During five trips to Mexico, Times reporters purchased and tested 55 pills from 29 pharmacies in eight cities. More than a third of the opioid painkillers tested — 15 out of 40 — were counterfeit, the vast majority positive for fentanyl. One tested positive for a weaker medication and another tested positive for no drugs at all. Meanwhile, 12 of 15 Adderall samples tested positive for other substances, including methamphetamine and, in one case, MDMA, the designer drug commonly known as ecstasy. Others were purchased in Tijuana and Nuevo Progreso, border towns with booming medical and pharmaceutical tourism sectors. In most of those locations, the pills that tested positive came from independent pharmacies, where workers sold them over the counter, one tablet at a time. But in Puerto Vallarta, counterfeits were available even at one regional pharmacy chain — the sort of place where people might expect more quality control. Both there and in Nuevo Progreso, pills purchased in sealed bottles tested positive for more powerful drugs, a possible sign of the sophistication of fakes made by cartels, which experts say are likely the source. It is unclear how high the death toll might actually be. Times reporting confirmed that at least half a dozen Americans have overdosed or died after taking counterfeit pills purchased from pharmacies. An alert by the U. March 18, Now, given the new testing that shows how common tainted pills are in stores throughout the country, some drug-market experts worry the problem could have a far broader reach, to include tourists from outside of the Americas. Mexican government officials have ignored repeated requests for comment, except for one federal prosecutor who said this month that her office would comment only if reporters revealed the names and locations of the pharmacies they visited. The U. Drug Enforcement Administration has known about the problem since at least When asked whether she was aware of reporting about Mexican pharmacies selling fentanyl- and methamphetamine-tainted pills, she left without responding. Later, she offered comment through a spokeswoman via email, without addressing the specific questions posed. We are continuing our enforcement and education efforts on this important issue to save lives. On a late spring day in Puerto Vallarta, tourists carrying Starbucks cups and cans of Michelob Ultra strolled along the bougainvillea-lined avenues of the bustling Zona Romantica. But in between its bars and boutiques are dozens of drugstores, many willing to sell powerful medications over the counter. Mexico has long been a mecca for Americans seeking easier and cheaper access to medications that require a prescription in the U. In theory, oxycodone and amphetamines are much more tightly controlled. Between the time U. April 10, And yet, in the cities reporters visited, finding stores that would sell them without a prescription proved easy. Sometimes, reporters compiled a list of potential pharmacies to visit by scouring Reddit, following emailed tips or browsing online pharmacy reviews. Other times, the starting point was a Google Maps search for nearby pharmacies. To buy pills for testing, reporters walked into drugstores in tourist areas and asked — usually in English — for Adderall and either Percocet or oxycodone. In some cases, pharmacy employees said to come back after the daily delivery came in, or they made a quick call to have tablets brought over from off-site. Afterward, reporters ground up a portion of each pill and used test strips to determine whether they contained fentanyl or methamphetamine, following a protocol recommended by UCLA researchers who conducted their own testing earlier this year. Samples of about one-third of the medications were later tested at a laboratory with a mass spectrometer, which helped confirm initial results and identify other adulterants — including MDMA and caffeine. The results expand on findings released earlier this year by the UCLA research team, which used an infrared spectrometer to show that 20 out of 45 pills purchased in four northwestern Mexico cities were counterfeits containing fentanyl, methamphetamine or heroin. Since then, reporters have worked to answer some of those questions, first by uncovering evidence of multiple overdoses and several deaths, and now by showing the problem is far more widespread than was previously known. Though The Times found counterfeits in each of the eight cities where they did testing, there were major variations when it came to availability, cost and the odds of a given pill being fake. Farther south, in the upscale resort cities of the Riviera Maya, fewer pharmacies would sell powerful narcotics without a prescription. Pills sold as Adderall proved consistently unreliable across the country, but the odds of a tablet sold by a pharmacy as oxycodone or hydrocodone being a dangerous fake varied from city to city. Each of the several opioids reporters tested in Cabo San Lucas came up positive for fentanyl; none did in Puerto Vallarta. In Puerto Vallarta, one sample of hydrocodone — commonly known by the brand name Vicodin — turned out to be a weaker medication instead. In , the family of a man killed by a fentanyl pill from a Mexican pharmacy called on U. Dianne Feinstein and then-Sen. Kamala Harris to act. Little has been done in the intervening years. April 21, UCLA researchers earlier this year purchased one sample of supposed oxycodone that turned out to be heroin, also from a drugstore in an unnamed city along the western coast. That was partly because some stores there appeared to be getting legitimate pills from nearby Guatemala and reselling them. Several pharmacies offered purple oxycodone in blister packs bearing the name of a Guatemalan drugmaker, along with a Guatemalan drug register number. None of the blister packs reporters purchased in any city tested positive for other drugs. But in Nuevo Progreso, a sealed bottle of Percocet tested positive for fentanyl. Even more troubling, in Puerto Vallarta every sealed bottle of medication reporters purchased — including four bottles of supposed Adderall and one of supposed hydrocodone — was counterfeit, testing positive for methamphetamine and tramadol, respectively. Usually, there were obvious red flags: Several had typos in their labels, and a few were entirely in English with complete American National Drug Code, or NDC, numbers. To Felbab-Brown, the Brookings Institution cartel expert, the sophistication and prevalence of counterfeit drugs at pharmacies is reminiscent of the way Mexican criminal organizations infiltrated the fishing industry a few years ago. But because the problem is not limited to that region, it could affect a different population of visitors. Connor Sheets is an investigative and enterprise reporter at the Los Angeles Times. Before joining the Los Angeles Times in , she spent nearly seven years in Texas, first covering criminal justice for the Houston Chronicle and then covering prisons for the Marshall Project. De Los. Times Everywhere. For Subscribers. All Sections. About Us. B2B Publishing. Hot Property. Times Events. Times Store. Special Supplements. In Puerto Vallarta, every Adderall pill Times reporters purchased from pharmacies and tested was a counterfeit containing methamphetamine. By Connor Sheets and Keri Blakinger. Share via Close extra sharing options. And at least half of them were fakes. Medications are lined up on wide shelves in a pharmacy in Puerto Vallarta. Playa del Carmen is best known for its beaches, nightlife and entertainment, but Times reporters found that some of its pharmacies are passing off dangerous substances, including fentanyl and methamphetamine, as legitimate medications. California U. A nighttime scene of a city nestled among small hills. A combination pharmacy, souvenir shop and beach supply store peddles its wares in Playa del Carmen. Times reporters learned that some pharmacies in Puerto Vallarta sell bottles of fake Adderall containing methamphetamine. California Harris, Feinstein told in of American killed by fentanyl pills from Mexican pharmacy. Playa del Carmen is one of several beachfront destinations across Mexico where some pharmacies sell tainted, counterfeit medications to tourists. More to Read. Chinese chemical manufacturer is targeted by federal prosecutors trying to stop flow of fentanyl. Old newspaper boxes are being used to distribute the overdose reversal drug naxolone. An industrial chemical is showing up in fentanyl in the U. Connor Sheets. Keri Blakinger. More From the Los Angeles Times. Defense chief promises Ukraine what it needs to fight Russia but goes no further.

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Grifols is a leading global healthcare company. Our trusted and innovative plasma-derived medicines, other biopharmaceuticals and solutions in transfusion medicine enable millions of patients around the world to lead more productive lives. Since our founding in , our ever-growing mastery of plasma, diagnostics and life sciences, backed by our ethical leadership and industry-leading quality and safety standards, have contributed to a healthier and more sustainable society. GigaGen Awarded U. Thomas Glanzmann becomes non-executive Chairman. Our deep and expanding knowledge of plasma and the life sciences is helping us better understand human health and research potential treatments to improve it. Aligned with the United Nations plan to achieve the Sustainable Development Goals defined in its Agenda, we work every day to do more and do better to contribute to the health and quality of life of people around the world. Our innovative medicines made from human plasma enable millions of patients with chronic and rare diseases to lead more fulfilling lives. We trace our roots back to when Dr. Josep Antoni Grifols i Roig founded a clinical analysis laboratory in Barcelona, the precursor to Laboratorios Grifols. Grifols' mission, to improve people's health and well-being, has patients, donors and society at the heart of everything we do. Technique for pretransfusion tests based on the Ag-Ab reaction antigens-antibodies , causing a given agglutination, which can then be observed to determine the blood type. This technique can be performed in a tube, a gel column or on microplates. System used to group human blood into different types depending on the presence or absence of certain markers on the surface of the red blood cells. Plasma protein fraction commonly used as a macromolecular medium in the incubation of laboratory tests, reducing what is known as the 'zeta-potential'. As a hemoderivative, it is used as a plasma volume expander and for protein replacement in some cases. Exploratory radiological technique in which a contrast fluid is injected into the vascular system to render the blood opaque and thus enable observation of the internal state of blood vessels. Antigens have the capacity to stimulate the immune system, triggering a response in the form of antibodies. This reaction determines compatibility between different blood groups. First, the antigen binds to the antibody. The antibodies then react to the appearance of contrary antigens, causing the red blood cells to form clumps or agglutinate. Deoxyribonucleic acid: a nucleic acid that contains the genetic instructions used in the development and functioning of all living organisms and some viruses. It is also responsible for hereditary transmission. Serum or reagent that contains specific antibodies immunoglobulins against one or more antigens. Crystalline or colorless organic substance found primarily in the blood and urine. It is formed in the liver as an end product of metabolism and excreted in urine and sweat. Biological study of blood serum. Study of the antigen-antibody complexes in serum, to detect the presence of certain diseases. Instrument combining the properties of a spectrometer and a photometer, used to determine the intensity of any range of wavelengths absorbed by a solution. Distribution of the intensity of radiation as a function of a given magnitude, such as wavelength, energy or temperature. Probability mathematical or statistical that the transfusion of a blood component might transmit an infectious agent virus after performing tests using direct or indirect detection methods, antigen methods or based on immune response elements. The Rhesus Rh factor is an inherited protein found on the surface of red blood cells. Ribonucleic acid. This is a nucleic acid formed from a chain of ribonucleotides, present in eukaryotic and prokaryotic cells, which participates in the intermediate stages of protein synthesis, following the program recorded in the genetic code. The observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment. Pipetting involves using a pipette to draw up a given quantity of liquid. The technique allows liquids to be dispensed quickly and accurately. Liquid portion of uncoagulated blood, yellow in color, obtained after separating out the cellular elements. Contains water, electrolytes, proteins, fats and proteins. Platelets, also referred to as thrombocytes, are tiny fragments of cytoplasm from very large cells called megakaryocytes. Platelets are formed from these large cells in the bone marrow and are released into the bloodstream, where they are essential for enabling normal blood coagulation. Technique by which whole blood is extracted from a donor and processed to separate the white blood cells, red blood cells and platelets from the plasma. The blood cells are then returned to the donor, minus the plasma, which the body can replace rapidly. Technique to observe agglutination, using plates with multiple wells which are used as small test tubes. This technique enables automation of the process and is used for large series of samples. Conservation method that consists of conducting a sublimation process by dehydrating a substance through rapid freezing, and transforming the ice humidity into vapor by means of the application of vacuum. Plasma protein associated with immune processes. All antibodies are immunoglobulins, but not all immunoglobulins perform the antibody function. The volumetric proportion of red blood cells in the blood. This value is obtained by performing a blood test in a laboratory. The normal hematocrit values depend on the references selected by the laboratory. Hemostasis is the interruption of hemorrhage either spontaneously or by physical means, such as manual compression or tourniquet, or chemical means, such as the use of drugs. Device that regulates the optimum temperature, humidity and ventilation to preserve and grow microbiological and cell cultures in a laboratory. Essential for much experimental work in biology, and in pharmaceutical, hematological and biochemical studies, among others. Study that makes it possible to identify the composition of blood and which is used as a clinical analysis tool. Heparin is a natural substance in the blood which interferes with the blood clotting process. It acts on a substance called thrombin, which plays an important role in the formation of blood clots. Genotyping is the process by which differences in the genetic makeup or genotype of an individual are identified by analysis of their individual DNA sequence. This can be done by comparing the genotype with another individual's sequence or with a reference sequence. Glass tube with vacuum, used to obtain blood samples for clinical analysis under aseptic conditions. Enzyme-linked immunosorbent assay: immunological technique where the reaction between antigen and antibody is detected by spectrophotometric determination of the action of an enzyme that is linked to the antigen or antibody. It is cheaper and simpler than radioimmunoassay, with similar effectiveness. It is also called enzyme immunoanalysis or enzyme immunoassay. Red blood cells, also referred to as erythrocytes, are the most common type of blood cell, and are responsible for transporting oxygen from the lungs to the different tissues, organs and systems of the body, a task they perform thanks to a protein called hemoglobin. Laboratory instrument that applies centrifugal force to accelerate the separation of solid particles suspended in a liquid, based on their density. It is used, for example, to separate plasma and blood serum from blood cell components during analysis for blood testing. Sodium citrate is the sodium salt of citric acid. It is used as an anticoagulant in tubes used to extract blood in some laboratory tests that measure blood clotting time, including activated partial thromboplastin time and prothrombin time. The concentration of sodium citrate used as an anticoagulant is an important pre-analytic variable because blood plasma clotting time may vary as the quantity of citrate present affects the concentration of calcium used in these tests. Diagnostic test that can detect the presence of antibodies in the serum that react with antigens on the surface of the red blood cells. Used to diagnose blood disorders in which the patient produces antibodies against their own red blood cells and platelets. Also used to determine blood type. Agglutination technique to determine blood groups and for transfusion compatibility studies, which uses gel as a reagent. This gel sits in columns on cards of 6 to 8 wells. Organic chemical substance that is the basic component of proteins. Microorganism contagion from patient to health professional, from health professional to patient, or from patient to patient. Occurs when microorganisms are transferred to nearby equipment, clothing or furniture. Treatment with drugs to interrupt the formation of cancer cells, whether by destroying them or by preventing them from multiplying. Chemotherapy is administered orally, by injection, by infusion or onto the skin, depending on the type of cancer and the stage of the disease. It is administered alone or combined with other treatments such as surgery, radiation therapy or biological therapy. Revolving cabinets. The contents of the system are transported by a structure that rotates either vertically or at floor level. Both systems facilitate the product selection process by transporting the items to the operatives. Carousels optimize storage space and selection time. Package consisting of two layers, normally plastic and metal aluminum , heat-set to form ampoule-shaped cavities which can contain individual doses of the product. This form of presentation facilitates identification of the tablet and protects individual tablets from external agents. Device that uses water vapor at high pressure and high temperature to destroy microorganisms, in order to achieve asepsis. Used to sterilize non-disposable hospital and surgical material, in the manufacture of parenteral solutions, and with other products that need to be sterilized and can withstand this physical process. Introduced into the organism via the gastrointestinal tract, whether orally or via the nasogastric route. Acronym of Food and Drug Administration. The government agency of the US Department of Health and Human Services that is responsible for regulating food, drugs, biological products and blood-derived products. In the pharmaceutical industry, the standardized process of aseptic filling of pharmaceutical products, parenteral solutions or plasma-derived products. The fraction of plasma proteins that remains insoluble when the fresh frozen plasma is thawed under appropriate temperature conditions. Refers to a drug or therapy used to treat cancer by inhibiting cell proliferation, such as in anti-tumor treatments. Substance or product derived from blood or plasma. Pharmaceutical preparations whose active principle comes from the blood of healthy donors via an appropriate fractionation and purification process, and which cannot be obtained using chemical or biological synthesis methods. Therapy consisting in the parenteral administration of liquids and electrolytes, in order to maintain or reestablish homeostasis in the patient's body. The main objectives are to maintain adequate hydration and tissue perfusion with electrolytic equilibrium. Any treatment consisting in introducing specific genes into the patient's cells to combat certain diseases. Action and effect of introducing a gas, liquid or drug solution into a blood vessel, body cavity or tissue under pressure using a syringe or suitable instrument. Technique of introducing a liquid into the bloodstream in order to hydrate the patient or administer a drug. Hereditary disease, transmitted by autosomal recessive inheritance — the presence of two copies of an abnormal gene — and sex-linked, in which there is a deficit in the production of various plasma factors that are essential to correct blood coagulation: factor VIII hemophilia A and factor IX hemophilia B. Any treatment consisting in the administration and monitoring of liquids, medicines or both into the general bloodstream by piercing a vein. The aim is to ensure maximum therapeutic impact in comparison to oral therapy, which tends to take longer to act and be less effective. Preparation obtained by adding medicines for intravenous use to containers of solutions for fluid therapy. Can be prepared either by reconstitution by dissolving a solid medicine in a solvent or by mixing preparations in an existing watery solution. Branch of medicine that manages the treatment of anomalous cell proliferation tumor using cytostatic drugs, radiation therapy, immunosuppression or surgery of cancerous tumors. Medical discipline that improves the quality of life of patients with a range of pathologies by providing specific nutritional therapy to patients who find it difficult or impossible to ingest food, or provided as a complement to food. Name given to fatty materials and analogous triglycerides. Lipid solutions or emulsions are mixtures created by dissolving lipids in a liquid for intravenous use. In medicine, device that responds to a stimulus, such as heat, light or pressure, and produces a signal that can be measured or interpreted. Thermoplastic obtained by polymerizing propylene, a gaseous by-product of petroleum refining. It is an inert material that is suitable for the preparation of some intravenous mixtures that are incompatible with other plastics. In medicine, the action of introducing a liquid such as blood, serum or antibiotic into the body intravenously in a slow, sustained manner. Device used to administer intravenous liquids, consisting of a plastic tube, a regulating clamp, a connection and a syringe. Introduced into the organism by a pathway other than the digestive tract, such as intravenous, subcutaneous, intramuscular or intradermal. Parenteral solutions are typically constituted with saline solution, gluconate or a combination of these, and may contain amino acids, electrolytes, vitamins or drugs, or they may be lipid emulsions of various products that are not water-soluble. Organic compound belonging to the amino acid group, present in some foods of animal origin and also occurring naturally in some of our body tissues. Intervenes in the formation of bile and many other functions. Its name derives from the Latin taurus meaning bull because it was first isolated in the bile of a bull in by the German scientists Friedrich Tiedemann and Leopold Gmelin. Small flask containing injectable medicine, from which doses of the medicine are extracted as required. Room that has been specially designed to ensure low levels of contamination. 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Analyst Coverage. Financials Financial Results. Annual Accounts. Fixed Income and Credit Ratings. Average Period of Payment to Suppliers. Key Figures. Press Releases. Presentations and Events. Other Relevant Information. Inside Information. Significant events until 8 February Corporate Stewardship Reports. Corporate Governance Board of Directors. Annual Corporate Governance Report. Directors' Reumuneration Report. Articles of Association. Corporate Policies. Careers Careers Training and Development. Media Media Media Contacts. Newsroom Newsroom Press Releases. Company Statements. Media Center. Connect with us. Innovating for Patients and Society. What We Do. Latest news. Read Release. Show more news. Read more. Commitment to people and the planet Aligned with the United Nations plan to achieve the Sustainable Development Goals defined in its Agenda, we work every day to do more and do better to contribute to the health and quality of life of people around the world. The patients we serve are able to lead better lives. Patients inspire the work we do every day. Get to know us. Our history We trace our roots back to when Dr. Company Grifols' mission, to improve people's health and well-being, has patients, donors and society at the heart of everything we do. Careers Would you like to make a positive impact on the lives of others? Join our team! Find out more about Grifols' International Headquarters. Select your country Australia New Zealand. Vacuum gauge A vacuum gauge is a device used to measure the pressure and vacuum in specific spaces. Agglutination technique Technique for pretransfusion tests based on the Ag-Ab reaction antigens-antibodies , causing a given agglutination, which can then be observed to determine the blood type. ABO blood group system System used to group human blood into different types depending on the presence or absence of certain markers on the surface of the red blood cells. Albumin Plasma protein fraction commonly used as a macromolecular medium in the incubation of laboratory tests, reducing what is known as the 'zeta-potential'. Antibody Protein synthesized by the body in response to the introduction of an antigen. Angiography Exploratory radiological technique in which a contrast fluid is injected into the vascular system to render the blood opaque and thus enable observation of the internal state of blood vessels. Blood agglutination Antigens have the capacity to stimulate the immune system, triggering a response in the form of antibodies. Angiogram X-ray or image of the blood vessels and flow of blood within the body. Anticoagulant Substance that prevents or reduces blood coagulation. Antiglobulin Antibody that reacts with the plasma globulins. DNA Deoxyribonucleic acid: a nucleic acid that contains the genetic instructions used in the development and functioning of all living organisms and some viruses. Asepsis Absence of pathogenic micro-organisms. Antiserum Serum or reagent that contains specific antibodies immunoglobulins against one or more antigens. Antigen Foreign body that enters the organism and prompts an immune response. Artificial vision This is the process of obtaining, describing and interpreting information from images. Urea Crystalline or colorless organic substance found primarily in the blood and urine. Screening Refers to a preliminary test or study. Serum Liquid portion of coagulated blood. Sulfonamide Chemical substance derived from colorants, used in the treatment of several infectious diseases. Spectrophotometry Measurement of the relative light intensity of simple emissions. Spectrophotometer Instrument combining the properties of a spectrometer and a photometer, used to determine the intensity of any range of wavelengths absorbed by a solution. Residual transfusion risk Probability mathematical or statistical that the transfusion of a blood component might transmit an infectious agent virus after performing tests using direct or indirect detection methods, antigen methods or based on immune response elements. Rh factor The Rhesus Rh factor is an inherited protein found on the surface of red blood cells. RNA Ribonucleic acid. Rheostat Instrument to vary the resistance of an electrical circuit. Phenotype The observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment. Photometer Device that measures light intensity. Pipetting technique Pipetting involves using a pipette to draw up a given quantity of liquid. Photometry Measurement of light intensity and of corresponding amplitudes. Plasma Liquid portion of uncoagulated blood, yellow in color, obtained after separating out the cellular elements. Pyrogenic Fever-inducing. Lyophilized plasma Plasma that has undergone lyophilization to extend its shelf life. Platelets Platelets, also referred to as thrombocytes, are tiny fragments of cytoplasm from very large cells called megakaryocytes. Plasmapheresis Technique by which whole blood is extracted from a donor and processed to separate the white blood cells, red blood cells and platelets from the plasma. Nomogram Graphic representation that enables rapid approximate numerical calculation nomography. Nephritis Inflammation of the kidneys. Microplate technique Technique to observe agglutination, using plates with multiple wells which are used as small test tubes. Microcentrifuge Specialized centrifuge used in a clinical laboratory for capillary tubes. Lyophilizer A lyophilizer is a device used to perform lyophilization. Lyophilization Conservation method that consists of conducting a sublimation process by dehydrating a substance through rapid freezing, and transforming the ice humidity into vapor by means of the application of vacuum. Immunoglobulin Plasma protein associated with immune processes. Hematocrit The volumetric proportion of red blood cells in the blood. Hemolysis The process of decomposition of red blood cells. Hemostasis Hemostasis is the interruption of hemorrhage either spontaneously or by physical means, such as manual compression or tourniquet, or chemical means, such as the use of drugs. Inoculate Introduce into an organism a substance that contains the germ of a disease. Incubator Device that regulates the optimum temperature, humidity and ventilation to preserve and grow microbiological and cell cultures in a laboratory. Hemogram Study that makes it possible to identify the composition of blood and which is used as a clinical analysis tool. Genotype An individual's set of genes. Heparin Heparin is a natural substance in the blood which interferes with the blood clotting process. Heparinization Treatment with heparin to prevent blood coagulation. Globulin Particular class of protein, to which antibodies belong. Genotyping Genotyping is the process by which differences in the genetic makeup or genotype of an individual are identified by analysis of their individual DNA sequence. Flebula Glass tube with vacuum, used to obtain blood samples for clinical analysis under aseptic conditions. ELISA technique Enzyme-linked immunosorbent assay: immunological technique where the reaction between antigen and antibody is detected by spectrophotometric determination of the action of an enzyme that is linked to the antigen or antibody. Red blood cell Red blood cells, also referred to as erythrocytes, are the most common type of blood cell, and are responsible for transporting oxygen from the lungs to the different tissues, organs and systems of the body, a task they perform thanks to a protein called hemoglobin. Centrifuge Laboratory instrument that applies centrifugal force to accelerate the separation of solid particles suspended in a liquid, based on their density. Sodium citrate Sodium citrate is the sodium salt of citric acid. Coombs test Diagnostic test that can detect the presence of antibodies in the serum that react with antigens on the surface of the red blood cells. Gel column agglutination technique Agglutination technique to determine blood groups and for transfusion compatibility studies, which uses gel as a reagent. Amino acid Organic chemical substance that is the basic component of proteins. Cross contamination Microorganism contagion from patient to health professional, from health professional to patient, or from patient to patient. Chemotherapy Treatment with drugs to interrupt the formation of cancer cells, whether by destroying them or by preventing them from multiplying. Carousel Revolving cabinets. Blister pack Package consisting of two layers, normally plastic and metal aluminum , heat-set to form ampoule-shaped cavities which can contain individual doses of the product. Autoclave Device that uses water vapor at high pressure and high temperature to destroy microorganisms, in order to achieve asepsis. Enteral Introduced into the organism via the gastrointestinal tract, whether orally or via the nasogastric route. Industrial filling In the pharmaceutical industry, the standardized process of aseptic filling of pharmaceutical products, parenteral solutions or plasma-derived products. Cryoprecipitate The fraction of plasma proteins that remains insoluble when the fresh frozen plasma is thawed under appropriate temperature conditions. Cytostatic Refers to a drug or therapy used to treat cancer by inhibiting cell proliferation, such as in anti-tumor treatments. Hemoderivative Substance or product derived from blood or plasma. Fractionation Separation of therapeutic proteins from plasma using physical and chemical processes. Fluid therapy Therapy consisting in the parenteral administration of liquids and electrolytes, in order to maintain or reestablish homeostasis in the patient's body. Gene therapy Any treatment consisting in introducing specific genes into the patient's cells to combat certain diseases. Injection Action and effect of introducing a gas, liquid or drug solution into a blood vessel, body cavity or tissue under pressure using a syringe or suitable instrument. Intravenous infusion Technique of introducing a liquid into the bloodstream in order to hydrate the patient or administer a drug. Hemophilia Hereditary disease, transmitted by autosomal recessive inheritance — the presence of two copies of an abnormal gene — and sex-linked, in which there is a deficit in the production of various plasma factors that are essential to correct blood coagulation: factor VIII hemophilia A and factor IX hemophilia B. Intravenous therapy Any treatment consisting in the administration and monitoring of liquids, medicines or both into the general bloodstream by piercing a vein. Intravenous mixture IVM Preparation obtained by adding medicines for intravenous use to containers of solutions for fluid therapy. Nosocomial disease Refers to disease or infection acquired in a hospital or health facility. Oncology Branch of medicine that manages the treatment of anomalous cell proliferation tumor using cytostatic drugs, radiation therapy, immunosuppression or surgery of cancerous tumors. Clinical nutrition Medical discipline that improves the quality of life of patients with a range of pathologies by providing specific nutritional therapy to patients who find it difficult or impossible to ingest food, or provided as a complement to food. Lipid Name given to fatty materials and analogous triglycerides. Ranitidine Drug that inhibits the secretion of gastric acid, used in the treatment of stomach ulcers. Sensor In medicine, device that responds to a stimulus, such as heat, light or pressure, and produces a signal that can be measured or interpreted. Polypropylene Thermoplastic obtained by polymerizing propylene, a gaseous by-product of petroleum refining. Perfusion In medicine, the action of introducing a liquid such as blood, serum or antibiotic into the body intravenously in a slow, sustained manner. Perfusion System Device used to administer intravenous liquids, consisting of a plastic tube, a regulating clamp, a connection and a syringe. Parenteral Introduced into the organism by a pathway other than the digestive tract, such as intravenous, subcutaneous, intramuscular or intradermal. Sterile Free of pathogenic germs. Taurine Organic compound belonging to the amino acid group, present in some foods of animal origin and also occurring naturally in some of our body tissues. Intravenous Existing, occurring or administered in one or more veins. Vial Small flask containing injectable medicine, from which doses of the medicine are extracted as required. Clean zone Room that has been specially designed to ensure low levels of contamination. Jacketed vessel Tank designed to control the temperature of its contents through the use of an external cavity 'jacket' through which fluid is circulated, permitting heat exchange to produce uniform cooling or heating of the contents. Diaphragm pump A diaphragm pump is a type of positive displacement pump, generally alternating, in which pressure is increased through the action of elastic walls — diaphragms or membranes — that vary the volume in the chamber, alternately increasing and reducing it. Photocolorimeter Type of colorimeter. Capillary tube Fluid conduit with an interior diameter similar to that of a hair. Antiseptic Substance that destroys or inhibits the growth of microorganisms.

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