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Intermittent drugs seen highly protective against malaria. Malaria drugs given intermittently at the same time as routine childhood vaccinations could cut malaria episodes by nearly two-thirds, according to a randomised, placebo controlled trial reported in the 12 May issue of The Lancet. Dr David Schellenberg and colleagues from the Hospital Clinic in Barcelona, Spain, and the Ifakara Health Research and Development Centre, United Republic of Tanzania, randomly assigned either sulphadoxine- pyrimethamine, a commonly used antimalarial drug combination, or placebo to infants living in a rural area of the United Republic of Tanzania. All the children also received iron supplementation between 2 and 6 months of age. The Ifakara area where the trial was conducted has a high rate of malaria transmission and malaria is especially severe in underyear-old children. The treatment was well tolerated and no drug-attributable side-effects were observed. So this approach appears to be an extremely good buy. One concern about using chemoprophylaxis is that drug resistance may develop. However, Alonso argues that because the treatment is directly observed there can be no under-dosing, with its associated increased risk of inducing resistance. During a previous trial in the same area, full chemoprophylaxis between 2 and 12 months was associated with a large increase in the rate of malaria once treatment stopped, suggesting that the development of malaria-specific immunity had been delayed. However, no such rebound effect was seen in this study. The difficulty in the past has been finding the right balance between protecting children from malaria at the most vulnerable time without impairing their natural immunity. This approach seems to have got it right. Jacqui Wise, London, UK. News Intermittent drugs seen highly protective against malaria Malaria drugs given intermittently at the same time as routine childhood vaccinations could cut malaria episodes by nearly two-thirds, according to a randomised, placebo controlled trial reported in the 12 May issue of The Lancet.

Canadian gets death sentence in drug case

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The court in southern Guangdong province in China said on Tuesday that Canadian national Fan Wei, and 10 others, including an American and four Mexicans, were part of an international narcotics syndicate working out of Taishan city between July and November The group produced and sold Fan and a Chinese man who played a key role in operations were sentenced to death, the court said in a statement. The other foreigners were given suspended death sentences, which would be reduced to life imprisonment after two years while the rest of the men faced prison terms. We are obviously, particularly concerned when it is applied to Canadians. He is the second Canadian to be sentenced to death for drug offences in China this year, during a period of escalating tension between the two countries. In January, Robert Lloyd Schellenberg was handed the death penalty following a one-day retrial after he appealed an earlier year sentence in a separate drug trafficking case. China says that he was a key member of an international drug trafficking syndicate but Schellenberg claims that he was visiting as a tourist. The sentence came amid the backdrop of frosty diplomatic relations between China and Canada, with Beijing furious over the Vancouver arrest in December of a top executive from telecom giant Huawei on a US extradition request related to Iran sanctions violations. Schellenberg has appealed his sentence and Huawei chief financial officer Meng Wanzhou is fighting extradition. Published On 30 Apr 30 Apr Sponsored Content.

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