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Specific therapies that target vascular endothelial growth factor VEGF and its receptors have improved the survival of patients with metastatic cancers, but can induce side effects. Renal side effects proteinuria, hypertension and renal failure are underestimated. We collected 22 renal biopsies performed Nephrin, podocin and synaptopodin were variably down-regulated in all renal biopsies. VEGF was down-regulated in all glomeruli. This study underlines the importance of regular clinical and biological cardiovascular and renal checking during all anti-VEGF therapies for cancer for early detection of renal dysfunction. Collaboration between oncologists and nephrologists is essential. In such cases, renal biopsy might help in appreciating the severity of the renal lesions and after multidisciplinary discussion whether or not it is safe to continue the treatment. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. 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Google Scholar. Nolwenn Lorcy. Thibault Dolley-Hitze. Florence Jouan. Yannick Arlot-Bonnemains. Brigitte Laguerre. Gregory Verhoest. Jean Michel Goujon. Marc-Antoine Belaud-Rotureau. Nathalie Rioux-Leclercq. Select Format Select format. Permissions Icon Permissions. Abstract Background. Issue Section:. You do not currently have access to this article. Download all slides. Comments 0. Add comment Close comment form modal. I agree to the terms and conditions. You must accept the terms and conditions. Add comment Cancel. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email. Sign in Get help with access. ERA members Sign in through society site. Institutional access Sign in through your institution Sign in through your institution. 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