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In recent years, a growing number of prospective observational studies have consistently observed a paradoxical inverse association between atherogenic lipid fractions, particularly low-density lipoprotein cholesterol LDL-C and incident atrial fibrillation AF , suggesting a protective role of hypercholesterolemia. However, elevated lipid levels at baseline study examinations increase likelihood of lipid-lowering therapy LLT initiation during follow-up, introducing substantial time-varying confounding. Consequently, patients under LLT may represent a more homogeneous clinical group for further exploration of the 'cholesterol paradox' in AF. We conducted a prospective cohort study of 90, UK Biobank participants aged 40—69 years, who did not have history of AF at baseline and who reported use of any kind of LLT during a nurse-led interview. Baseline LDL-C was measured in non-fasted serum samples using a direct assay. We considered two covariate adjustment sets: Model 1 - including age, sex and body mass index; and Model 2 further including ethnicity, deprivation index, smoking status, alcohol intake, systolic and diastolic blood pressure, glycated hemoglobin, anti-hypertensive and anti-diabetic medication use, prevalent coronary heart disease and valvular heart disease. Potential non-linearity was explored using restricted cubic splines. During a median of The median baseline serum LDL-C was 2. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Advertisement intended for healthcare professionals. Sign in through your institution. ESC Publications. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Cholesterol paradox in atrial fibrillation: is it solved in lipid-lowering drugs users? B Bartos , B Bartos. Oxford Academic. Google Scholar. P Cyganski. University of Warmia and Mazury in Olsztyn. A Rynkiewicz. J Morze. Funding Acknowledgements: None. Select Format Select format. Permissions Icon Permissions. Abstract Background. Additionally, the absence of genetic evidence supporting a protective role of lipids further suggests that the 'cholesterol paradox' in AF may be attributed to residual confounding rather than a causal relationship. Open in new tab Download slide. All rights reserved. For commercial re-use, please contact reprints oup. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals. Issue Section:. Download all slides. Comments 0. Add comment Close comment form modal. I agree to the terms and conditions. You must accept the terms and conditions. Add comment Cancel. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email. Views More metrics information. Total Views Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic. More on this topic Achievement of European guideline-recommended lipid levels post-percutaneous coronary intervention: A population-level observational cohort study. Lipid levels and the use of lipid-lowering agents in England and Scotland. Phenotypic characterization of people at risk of atrial fibrillation: protocol for the FIND-AF longitudinal cohort study. A randomized controlled implementation study integrating patient self-screening with a remote central monitoring system to screen community dwellers aged 75 years and older for atrial fibrillation. Related articles in PubMed Gastrojejunostomy junction perforation resulting from Dobhoff tube insertion in a patient with a history of Roux-en-Y surgery: a case report. Lipid metabolism and hearing loss: association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio NHHR with adolescent hearing health. Citing articles via Google Scholar. High nicotine dependence — does knowing your genetic susceptibility for atrial fibrillation help to quit smoking? More from Oxford Academic. Cardiovascular Medicine. Clinical Medicine. Medicine and Health. Authoring Open access Purchasing Institutional account management Rights and permissions. Get help with access Accessibility Contact us Advertising Media enquiries.

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COVID resources for Aboriginal people including fact sheets, posters, videos, radio messages and support phone lists. Know about the potential health risks associated with cosmetics manufactured outside of Australia and available for purchase online. There is a range of services available to provide support and immediate response to people in crisis or in need of urgent medical care. To help protect people most at risk from COVID, COVID cases and close contacts should not visit high-risk settings, such as: hospitals residential disability, mental health and aged care facilities other healthcare settings e. GP clinics, dental services, physiotherapy, Aboriginal Medical Services. How to buy, use, store and dispose of household products that contain chemicals and poisons. Properties contaminated by meth or drug activities have varied levels of health risk. 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Fluoride in drinking water and toothpaste can help to prevent dental health problems. Hyperthyroidism is a health condition where your thyroid becomes overactive and produces too many hormones. It is a serious health condition that is fatal if left undiagnosed or untreated. Vaccine preventable diseases, such as measles or mumps, can have serious health consequences for school-aged children and others in the community. You can help protect your child by ensuring his or her vaccinations are up-to-date. All newborn babies in Western Australia undergo a blood screening test for serious genetic conditions in the first few days of their life, which is provided free of charge. Once your doctor knows what your heart condition is, he or she will then decide what treatments or procedures you may need. It is important to clean and care for your catheter according to the instructions given to you by your health professional. The cause of bowel cancer is still unknown; however research has identified a number of factors that increase the risk of developing bowel cancer. If you have unprotected vaginal, oral or anal sex or share needles or unsterile medical equipment you face a significant risk of getting sexually transmitted infections or blood-borne viruses. Partnering with your health care provider or carer when you have a chronic condition ensures your health care is planned around your individual circumstances, needs and preferences. Midwifery Group Practice allows women and families having a baby to be cared for by a known midwife throughout the journey. Skip to navigation Skip to main content Site map Accessibility Contact us. Search this site Search all sites Search. Go to whole of WA Government Search. Open search bar Open navigation Submit search. Facebook Youtube Twitter. Home HealthyWA search results. Buying make up and skin products online - Emergency and crisis - COVID coronavirus - Cervical Screening Registry - COVID cases and contacts - COVID testing - Buying, using, storing and disposing of household chemicals - Testing or cleaning a house for drug contamination - Donor Conception Information Service - Contact tracing for sexually transmissible infections and blood-borne viruses - Fluoridated drinking water - Contact tracing for tuberculosis TB - Pregnancy and pesticides - Acanthamoeba and contact lens use - Contact us - Cancer Nurse Coordination Service - Emergency ambulance fees for seniors and pensioners - Cryptosporidium infection Cryptosporidiosis - Mental illness specialised services for children and adolescents - Contact tracing - Where to get help for a chronic condition - Centre for Clinical Interventions - First aid for a choking adult or child over 1 - Fluoride facts for Western Australia - Asbestos — contact details - Fluoride and protecting your teeth from tooth decay - Hyperthyroidism overactive thyroid - Starting or moving child care, kindergarten or school — immunisation requirements - Possible side effects of vaccination - Common medical procedures for heart conditions - Caring for your catheter - Caring for your hydrocolloid dressing - Hypothyroidism underactive thyroid - Public hospital patient feedback - Infections spread by sexual or blood contact overseas - Partnering with your health care provider - Facebook Twitter Youtube.

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