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Attention has been focused on isatin-based oxindole scaffolds, for which promising results concerning butyrylcholinesterase BuChE inhibitory activity have previously been obtained. Considering some published reports and detailed analysis of the pharmacophores of commercially available drugs for AD powerful cholinesterase ChE inhibitors , we performed a strategic structural modification of the isatin core and generated a new family of isatin-based oxindole hybrids 27 new compounds possessing crucial key functional units in their framework. The syntheses were accomplished using multiple approaches, including simple N -alkylation reactions, copper-catalyzed amination reactions, and click chemistry. The resulting library was evaluated on ChE and MAO enzymes, both of which are involved in the pathophysiology of neurodegeneration. IC 50 values of 1. Received: 30 November Accepted after revision: 04 January Article published online: 16 February Year Archive Related E-Products. Download PDF. Synthesis ; 54 19 : DOI: Carolina S. Luisa Leitzbach. Holger Stark. Anthony J. Supporting Information. Google Scholar. Crossref PubMed. Article in Thieme Connect.

Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases

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Skip to main content This page works best with JavaScript. Disabling it will result in some disabled or missing features. You can still see all customer reviews for the product. Customer Review. Verified Purchase. My spouse has dementia, and has been on Aricept for years. Amen says that Exelon is often his first choice to treat dementia. This he says helps stop the buildup of plaque in the brain that Dr's see in patients at the end. Given this info - I asked our dr. Amen said he and his physicians see an improvement in 50 percent of their patients. Granted Exelon is expensive if you do not have insurance but our insurance covered all of this medicine. Wish we had been on it from the beginning. One person found this helpful. Showing 0 comments. There was a problem loading comments right now. Please try again later. Product Details. Amen M. See All Buying Options.

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A Review of Butyrylcholinesterase as a Therapeutic Target in the Treatment of Alzheimer’s Disease

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