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Use of surgical adjuvant chemotherapy employing a combination of cytotoxic drugs, e. Japan has long had a unique standpoint on this issue. There are two prominent views on the evaluation of postoperative chemotherapy for breast cancer patients. The first view is that breast cancer in Japanese women is biologically less aggressive than that in Caucasian women. The dominant opinion amongst Japanese surgeons is that cytotoxic chemotherapy is not indicated in node-negative breast cancer patients. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. 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