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Print this issue. People with addiction lose control over their actions. They crave and seek out drugs, alcohol, or other substances no matter what the cost—even at the risk of damaging friendships, hurting family, or losing jobs. What is it about addiction that makes people behave in such destructive ways? And why is it so hard to quit? NIH-funded scientists are working to learn more about the biology of addiction. The biological basis of addiction helps to explain why people need much more than good intentions or willpower to break their addictions. A healthy brain rewards healthy behaviors—like exercising, eating, or bonding with loved ones. It does this by switching on brain circuits that make you feel wonderful, which then motivates you to repeat those behaviors. At this stage, people often use drugs or alcohol to keep from feeling bad rather than for their pleasurable effects. To add to that, repeated use of drugs can damage the essential decision-making center at the front of the brain. This area, known as the prefrontal cortex, is the very region that should help you recognize the harms of using addictive substances. Nonetheless, they take it. Addiction tends to run in families, and certain types of Stretches of DNA, a substance you inherit from your parents, that define characteristics such as your risk for certain disorders, such as addiction. But not all members of an affected family are necessarily prone to addiction. Other factors can also raise your chances of addiction. Teens are especially vulnerable to possible addiction because their brains are not yet fully developed—particularly the frontal regions that help with impulse control and assessing risk. Pleasure circuits in adolescent brains also operate in overdrive, making drug and alcohol use even more rewarding and enticing. NIH is launching a new nationwide study to learn more about how teen brains are altered by alcohol, tobacco, marijuana, and other drugs. Researchers will use brain scans and other tools to assess more than 10, youth over a year span. The study will track the links between substance use and brain changes, academic achievement, IQ, thinking skills, and mental health over time. To treat addiction, scientists have identified several medications and behavioral therapies—especially when used in combination—that can help people stop using specific substances and prevent relapse. Unfortunately, no medications are yet available to treat addiction to stimulants such as cocaine or methamphetamine, but behavioral therapies can help. More severe cases might require months or even years of treatment and follow-up, with real efforts by the individual and usually complete abstinence from the substance afterward. NIH-funded researchers are also evaluating experimental therapies that might enhance the effectiveness of established treatments. Mindfulness meditation and magnetic stimulation of the brain are being assessed for their ability to strengthen brain circuits that have been harmed by addiction. Scientists are also examining the potential of vaccines against nicotine, cocaine, and other drugs, which might prevent the drug from entering the brain. When Cancer Spreads. Tired, Achy Eyes? Buffering Childhood Stress. Editor: Harrison Wein, Ph. Managing Editor: Tianna Hicklin, Ph. Illustrator: Alan Defibaugh. Attention Editors: Reprint our articles and illustrations in your own publication. Our material is not copyrighted. For more consumer health news and information, visit health. For wellness toolkits, visit www. Site Menu Home. Special Collections. October Print this issue. Featured Stories. Back to Top.