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These datasets underpin the analysis presented in the agency's work. Most data may be viewed interactively on screen and downloaded in Excel format. All countries. Topics A-Z. The content in this section is aimed at anyone involved in planning, implementing or making decisions about health and social responses. Best practice. We have developed a systemic approach that brings together the human networks, processes and scientific tools necessary for collecting, analysing and reporting on the many aspects of the European drugs phenomenon. Explore our wide range of publications, videos and infographics on the drugs problem and how Europe is responding to it. All publications. More events. More news. We are your source of drug-related expertise in Europe. We prepare and share independent, scientifically validated knowledge, alerts and recommendations. About the EUDA. The plant is endemic to a limited area of the highlands of the Mexican Oaxaca state, where the Mazatec Indians ingest its fresh leaves or leaf preparations for divinatory rituals, healing ceremonies and medical purposes. Smoking the dried and crushed leaves provides short-lived but intense hallucinations. The effective dose of salvinorin A , the active ingredient of the plant, is comparable to that of the synthetic hallucinogens LSD or DOB. The toxicity of Salvia divinorum is currently poorly understood. The main ingredient responsible for the psychoactive effect of the plant is a neoclerodane diterpene called salvinorin A. Unlike classical natural or synthetic hallucinogens, salvinorin A does not contain a nitrogen atom — it is not an alkaloid. The dried leaves, leaf extracts and pure salvinorin A are stable at ambient temperature in the absence of light or air, although there is no systematic study on this. Salvinorin A is unstable in basic solutions and is soluble in conventional organic solvents, including acetone, acetonitrile, chloroform, dimethyl sulfoxide and methanol, but is essentially insoluble in hexane and water. Salvia divinorum is a 0. It can be easily recognised from its square-shaped and hollow stem and opposite pairs of ovate-lanceolate, jagged-edged leaves, which are usually velvety or hairy. The characteristic flower of the plant has a white corolla surrounded by a violet blue calyx. Salvia divinorum hardly ever sets seeds, and even when produced, they are rarely viable. The propagation of the plant is thus exclusively vegetative and most of the Salvia divinorum plants now cultivated worldwide are clones of a few early Oaxaca collections. Dried and crushed leaves fortified with extracts from other leaves are dark green, brownish or even blackish green, due to concentrated pigments. Pure salvinorin A forms colourless crystals with a melting point of — o C. Salvinorin A has a unique mode of action and pharmacology. Salvinorin A shows no significant binding to over 50 other psycho pharmacologically important receptors, transporter proteins and ion channels. In humans, salvinorin A induces short-lived, profound hallucinations. Inhalation of doses equivalent to — micrograms of salvinorin A leads to loss of control over physical movements incapacitation ; uncontrollable laughter; vivid, colourful and often bizarre, dream- or film-like hallucinations. It has been reported that this can last for hours after the hallucinations have disappeared. Common after-effects include tiredness, dizziness and amnesia. Emergency reports have described lasting psychosis in vulnerable individuals. Although preliminary experiments by Mowry et al. Because Salvia divinorum seeds are difficult to obtain, the plant is propagated from cuttings. Seedlings as well as dried leaves are readily available either from Internet suppliers or specialised shops in countries where no regulatory restrictions exist. Home cultivation of plants is possible and instructions describing optimal growing conditions, the use of fertilisers and pest control chemicals are available on the Internet in several languages. Salvinorin A is found in the resin secreted by special, hairy epidermal cells trichomes , which are especially abundant on the leaves. Preparations of one leaf fortified by extracts of 4 to 49 other leaves the respective products then labelled as 5X to 50X extracts are also available online and in specialised shops. However, the actual salvinorin A concentration of Salvia divinorum products is generally unknown. Pure, crystalline salvinorin A does not appear to be offered on markets neither online or in smartshops but illustrated procedures for its isolation are available on the Internet. Chemical total syntheses of salvinorin A have recently been completed but they are too complex to be used for the production of the substance. To date, salvinorin A has not been found in any other Salvia species analysed. Alternatively, the fresh foliage is crushed by hand or ground on a milling stone which can be used for making a drinkable infusion. At least six fresh leaves are needed to achieve noticeable effects, which manifest after about 10 minutes and lasts for 45 minutes or longer. For recreational use, the most common way of administration is smoking the crushed dried leaves from a pipe or water bong, providing short-lasting 15—20 minute hallucinations within a minute. Typically, 0. Chewing the bitter leaves as a quid gives a longer lasting effect and the typical dosages to produce mild to medium effects are 10—30 grams of fresh leaves or 2—5 grams of dried leaves. Sublingual application of aqueous ethanol tinctures made from leaves results in an onset taking 5—10 minutes and lasting up to 2 hours. Drinking tea made by steeping the leaves in hot water is relatively ineffective because salvinorin A is readily degraded in the gastrointestinal tract. Health risks of inhaling the vapours of pure salvinorin A are high because the inhaled amount cannot be controlled. Names in other European languages include: French — sauge des devins, sauge divinatoire; German — Wahrsagersalbei. The salvinorin A content of botanical samples can be analysed by thin layer chromatography or high performance liquid chromatography with UV detection. The UV spectrum of the methanolic solution of salvinorin A shows a maximum at nm. The characteristic absorption bands in the infra-red spectrum of salvinorin A in KBr pellet are at 3 , 1 , 1 , 1 , and cm For the unequivocal identification of powdered plant material, DNA fingerprinting methods can be used. Salvinorin A and the other diterpenoids of the plant are not detected by conventional drug screening methods. However, in recent years both Salvia divinorum and its active principle salvinorin A have become controlled under drugs legislation in Belgium, Denmark, Italy, Latvia, Lithuania, Romania and Sweden, in Australia and Japan as well as in a number of states of the US. Croatia, Germany, Poland and Spain only regulate the plant. In Estonia, Finland and Norway, Salvia divinorum falls under medicines legislation. There is no approved medicinal use for Salvia divinorum or salvinorin A. However, there is intensive research to explore the therapeutic potential of structurally related KOR agonists or antagonists. Albertson, D. Appel, J. Baggott, M. Erowid, F. Bertea, C. Beerepoot, P. Biglete, S. Braida, D. Capasso, R. Carlezon, W. Chavkin, C. Epling, C. Giroud, C. Gruber, J. Grundmann, O. Hanes, K. Harding, W. Hofmann, A. Hooker, J. Imanshahidi, M. Jermain, J. Khey, D. Lange, J. Li, Y. McDonough, P. Medana, C. Mowry, M. Nozawa, M. Ortega, A. Paulzen, M. Pfeiffer, A. Pichini, S. Prisinzano, T. Przekop, P. Roth, B. Scheerer, J. Schmidt, M. Seeman, P. Siebert, D. Siemann, H. Tsujikawa, K. Vohra, R. Vortherms, T. Wolowich, W. Zhang, Y. Homepage Quick links Quick links. GO Results hosted on duckduckgo. Main navigation Data Open related submenu Data. Latest data Prevalence of drug use Drug-induced deaths Infectious diseases Problem drug use Treatment demand Seizures of drugs Price, purity and potency. Drug use and prison Drug law offences Health and social responses Drug checking Hospital emergencies data Syringe residues data Wastewater analysis Data catalogue. Selected topics Alternatives to coercive sanctions Cannabis Cannabis policy Cocaine Darknet markets Drug checking Drug consumption facilities Drug markets Drug-related deaths Drug-related infectious diseases. Recently published Findings from a scoping literature…. Penalties at a glance. Frequently asked questions FAQ : drug…. FAQ: therapeutic use of psychedelic…. Viral hepatitis elimination barometer…. EU Drug Market: New psychoactive…. EU Drug Market: Drivers and facilitators. Statistical Bulletin home. Quick links Search news Subscribe newsletter for recent news Subscribe to news releases. Breadcrumb Home Publications Drug profiles Salvia divinorum drug profile. Salvia divinorum drug profile. Molecular structure of salvinorum A.

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