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Rochester, NY. Thrombocytopenia is a common feature of systemic lupus erythematosus SLE. It is generally regarded as a manifestation of increased platelet destruction. The frequency of antibodies directed against tissue components in SLE offers a possible explanation for shortened platelet survival, although these antibodies have not been demonstrated in vitro. In striking contrast to the usual findings associated with thrombocytopenia in SLE are those we have recently observed in a young woman with this illness. Selective bone marrow aplasia with absence of megakaryocytes was documented in this instance. In addition, the survival of transfused platelets did not suggest immune destruction. To our knowledge, this observation has not been previously. Amegakaryocytic Thrombocytopenia in Systemic Lupus Erythematosus. Arch Intern Med. X Facebook LinkedIn. This Issue. February Paul F. Griner, MD ; Leon W. Hoyer, MD. Author Affiliations Rochester, NY. Access through your institution. Add or change institution. Save Preferences. Privacy Policy Terms of Use. Access your subscriptions. Free access to newly published articles. Purchase access. Rent article Rent this article from DeepDyve. Sign in to access free PDF. Save your search. Customize your interests. Create a personal account or sign in to:. Privacy Policy. Make a comment.

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