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Home » Specialties » Primary Care. Taffe, who was the principal investigator of the study. Synthesized by pharmaceutical companies decades ago but never used, cathinone derivatives were rediscovered by underground chemists in the early s. Cathinone derivatives inhibit the normal removal of the neurotransmitters dopamine, noradrenaline and serotonin from synapses the small gap separating neurons that enables cell-to-cell communication. In this way, the derivatives disturb the activity of brain networks that mediate desire, pleasure, muscle movements and cognition. Users have described classic stimulant effects such as an initial euphoria, increased physical activity, an inability to sleep and a lack of desire for food or water—plus almost irresistible cravings to take more of the drug. Higher doses bring a strong risk of paranoid psychoses, violence and suicide. Dickerson, to set up studies with laboratory animals. In a standard method for evaluating stimulant drugs, the animals were able to dose themselves intravenously by pressing a lever. As is typical for addictive stimulants, the rats maintained a steady self-administration of each drug whenever they could. In one set of tests designed to quantify how much the rats desired each drug, they could get another infusion only by making ever-greater numbers of lever presses. Aarde, who was first author of the study. MDPV increased the average activity level of the animals. But at higher—albeit still modest—doses, it produced repetitive behaviors similar to the tooth-grinding and compulsive skin-picking seen in human meth and MDPV users. He notes, however, that in the wake of the criminalization of first-generation cathinone derivatives, new members of this drug class are being invented that will also require study. He hopes in time to be able to anticipate how future chemical variations on the cathinone theme will change the way these drugs act on the brain. The study was supported by the U. Login Register. Enjoying our content? Thanks for visiting The Medical Bag. If you wish to read unlimited content, please log in or register below. Registration is free. Register for free and gain unlimited access to the latest in medical news, and lifestyle and business advice, with personalized daily picks for you. There's something for every health care professional on The Medical Bag. Continue Reading. Please login or register first to view this content. Open Next post in Primary Care Close. Log in to continue reading this article.

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