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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Mephedrone belongs to a group known as the substituted cathinone , which are derivatives of the active ingredient in the khat plant Catha edulluis. Mephedrone was first synthesized in , but did not become widely known until it was rediscovered in By , it was reported to be available for sale on the internet, by law enforcement agencies had become aware of the compound, and by it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally, producing effects which are somewhat similar to those of MDMA , amphetamine , and cocaine. It is reported to produce a mixture of classic stimulant and entactogenic effects effects reminiscent of cocaine and MDMA. Mephedrone, or 4-methylmethcathinone, is a synthetic molecule of the cathinone family. Amphetamines and cathinones are alpha-methylated phenethylamines, cathinones contain an additional carbonyl group at R 1. Given its chemical structure, mephedrone is likely to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as dopamine , serotonin and noradrenaline. Several articles published near the end of examined the effects of mephedrone in the brains of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured. They reached their peak concentrations at 40 minutes and 20 minutes and returned to baseline by minutes after injection. Analysis of the ratio for dopamine and serotonin indicated mephedrone was preferentially a serotonin releaser , with a ratio of 1. Additionally, half-lives for the decrease in dopamine and serotonin were calculated and found to have decay rates of These findings show mephedrone induces a massive increase in both dopamine and serotonin , combined with rapid clearance. This increase in neurotransmitters provides an explanation for the euphoric and stimulating subjective effects induced by this experience. The rapid rise and subsequent fall of dopamine levels could also explain some of the addictive properties of mephedrone display in some users. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Almost nothing is known about the long-term effects of mephedrone due to its short history of its use. In , unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK. By July , mephedrone had been alleged to be involved in 52 fatalities in the UK, but detected in only 38 of these cases. Of the nine that coroners had finished investigating, two were caused directly by mephedrone. Despite similarities to known neurotoxins such as methamphetamine and other cathinone derivatives, mephedrone does not appear to produce neurotoxic effects in the dopamine system of mice. It is strongly recommended that one use harm reduction practices when using this drug. As with other stimulants , the chronic use of mephedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of mephedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Mephedrone presents cross-tolerance with all dopaminergic stimulants , meaning that after the consumption of mephedrone all stimulants will have a reduced effect. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. Summary sheet: Mephedrone Mephedrone. Physical effects. Cognitive effects. After effects. July Archived from the original PDF on Retrieved BBC News. Forensic Science International 1 : e62—e PMID Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Die Presse. August 22, Retrieved December 27, State Food and Drug Administration. Archived from the original on 15 August Croatian Ministry of Health and Social Welfare. Estonian Ministry of Social Affairs. Archived from the original on September 21, City Magazine. Retrieved December 10, Bundesanzeiger Verlag. April 13, Isle of Man Today. February 25, Archived from the original on February 28, Irish Department of Health and Children. Archived from the original on February 21, Ministero della Salute. BBC Newsbeat. Retrieved December 26, United Nations Office on Drugs and Crime. Archived from the original on February 10, Archived from the original PDF on February 10, Misuse of Drugs Act S. London: The Stationery Office Limited. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Mephedrone.

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