Buy marijuana online in Santander

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Buy marijuana online in Santander

In Experiencia Natural we have been concerned about the genetic quality of our seeds since and we demonstrate it with a great selection that we offer you in our online store, where you can filter by attributes to get exactly what you need. You can buy autoflowering , feminized , regular or high CBD seeds from a lot of banks. Now, let's focus on what you need to get your seeds to adapt to the climate of your location, in this case oceanic , which translates into frequent rainfall and mild temperature changes between seasons. For this climate we recommend a variety of sativa dominance to resist humidity and fast flowering so that the hours of light, which will be scarce, do not affect us so much. Let's keep in mind that even adapting the genetics so that your flowers are ventilated, characteristics of the sativa, can arise complications with fungi , which will not worry us too much because we can not control the climate, but we have fungicides that are perfect for this little problem so feared. We also recommend good ventilation , which is essential for what we have already mentioned and which will make it very difficult for the damned fungi to appear. If you are a first time grower we advise you to read our blog first and read it carefully, so you can avoid silly mistakes. In our catalog we have very affordable prices and also in orders of more than 30 euros the shipment in 24 hours is free and you will get a seed gift , which will be two in the case of an expense of 60 euros and so on. Take a leisurely look around our online store and find everything you need. We're waiting for you! Necessary cookies help make a website usable by enabling basic functions like page navigation and access to secure areas of the website. The website cannot function properly without these cookies. Statistic cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. Home Marijuana seeds in Santander Cannabis seeds in Santander Sale of marijuana seeds in Santander In Experiencia Natural we have been concerned about the genetic quality of our seeds since and we demonstrate it with a great selection that we offer you in our online store, where you can filter by attributes to get exactly what you need. Necessary 6 Statistics 2 Cookie Policy Necessary Necessary cookies help make a website usable by enabling basic functions like page navigation and access to secure areas of the website. This cookie is native to PHP and allows the website to store serialised status data. Specifically, Google Analytics helps the website to analyse the use made by users of the website and thus improve its usability, but in no case are they associated with data that could identify the user. Google Analytics is a web analytics service offered by Google, Inc. Consult here the type of cookies and the privacy conditions used by Google. They are used to obtain anonymous statistics on the use of the website. Our customers have opined 4. Experiencia Natural Based in reviews. Show cart. Cookies for managing customer reviews related to ekomi Cookies for managing customer reviews related to ekomi. Delivery Delivery. Product search Product search. Google Analytics cookies Google Analytics cookies.

Marijuana seeds in Santander | Cannabis seeds in Santander

Buy marijuana online in Santander

Vice-president of the Spanish Pain Society. Author of 85 articles of which 55 in international journals indexed by JCR , and researcher in 31 projects and 27 contracts of which 15 as principal investigator. She has completed four six-year research periods, is co-inventor of two national patents, and is a member of the Spanish Society of Phytotherapy and the European Society of Phytochemistry. Recently, the Spanish parliament's Health and Consumer Commission has endorsed the regulation of medical cannabis in Spain. This is a pioneering initiative, both in terms of how it was carried out and due to the fact that the possibility of regulating the use of a plant rather than an active ingredient is being considered. One of the most frequently asked questions about cannabis and its medicinal use is whether it is preferable to use medicines made from the active ingredients of the plant or their synthetic derivatives, or to use the plant itself. Cannabis is an annual herbaceous plant and it is dioecious, i. The part of the plant that is used therapeutically and also in recreational use are the female flowers, which are arranged in inflorescences located in the axils of the leaves. The female flowers are protected by bracts modified leaves on which a large number of hairs can be observed. The active principles are found in these hairs: chemical compounds responsible for the pharmacological activity of cannabis Flores-Sanchez and Verpoorte, Chemically, we can highlight the presence of three types of molecules: Cannabinoids, Terpenes, and Flavonoids. Cannabinoids, and especially Tetrahydrocannabinol THC , have been extensively studied since These appear in the plant in the form of acids that are transformed by heating or combustion into the aforementioned compounds, which are the ones that really impact on our organism. The amount or concentration of the various cannabinoids differs from one strain to another, but since THC Is the one that has a psychotropic effect, the levels of this compound in the strains used for recreational use have been increasing over the last 30 years. Is the same thing happening with medical Cannabis? We will provide an answer later on. Many diseases are multifactorial, which means that the activation of different receptors may be required to achieve a therapeutic effect. Plants and their extracts, possessing complex mixtures of active principles, can achieve this objective better than a single synthetic compound, as the components can act synergistically. Whittle et al. The presence of multiple compounds in the same plant has given rise to the development of a concept known generally as the ' entourage effect ', which refers to the possible synergistic effects between the different components in this case cannabinoids of the plant, allowing for the improvement of its therapeutic capacities with respect to the isolated components. In this case, the effect would cover both cannabinoid-cannabinoid interaction and cannabinoid-terpenoid or cannabinoid-phenol interactions. In short, THC has been shown to have psychoactive, anti-inflammatory, anticancer, analgesic, muscle relaxant, neuro-antioxidant, antispasmodic, and bronchodilator effects. For its part, CBD exhibits anxiolytic, antiemetic, antipsychotic, antiarthritic, analgesic, anti-inflammatory, anticonvulsant, and immunomodulatory properties Andre et al. So far in Spain we only have two drugs made with cannabinoids: one of them is made with a mixture of THC and CBD and is indicated for the treatment of spasticity and pain in patients with multiple sclerosis, and for the treatment of opiate-resistant pain; the other, with CBD only, is used mainly for the treatment of seizures and epilepsy in children, although its usefulness in the treatment of chronic pain is currently being studied. One of the major advantages of these drugs is that we can precisely control the concentrations and dosage of the active ingredient administered to the patient, something that is much more complicated if we work with the medicinal plant as a whole. Despite the interesting therapeutic effects of THC, these are inevitably linked to undesirable side effects such as memory problems, attention problems, cognitive alterations, motor coordination difficulties, psychosis including schizophrenia , tachycardia, hypertension, or xerostomia. However, it has been shown that the joint administration of THC and CBD allows the appearance of joint effects synergistic and antagonistic , due to the entourage effect ; this would allow CBD to reduce the adverse effects of the former, such as psychotic symptoms and cognitive impairment Iseger and Bossong, Some studies, such as that of Johnson et al. These authors conducted a clinical trial comparing the efficacy of an extract with THC alone 2. These and other results point to a synergistic effect of both compounds, which would achieve a greater therapeutic effect, with lower doses than those required when the active ingredients are administered separately, and, therefore, with a lower incidence of side effects. In view of these data, it could be extrapolated that, likewise, the use of the plant as a therapeutic remedy, by providing both compounds and many more , would result in a reduction of side effects and therefore a greater acceptance of the treatment by the patient Wagner and Ulrich-Merzenich, In this sense, as mentioned, CBD would help to reduce side effects of THC such as anxiety, sedation, cognitive deficits, memory deficits, or hunger. The optimal ratio of CBD and THC in the plant or in the drug varies according to the pathology to be studied and is even different depending on the patient. The combination of both active ingredients reduces side effects, but we can surmise that it also improves tolerability. As mentioned above, the effects of isolated cannabinoids, as well as their synergistic effects, have been studied, and we can find abundant literature on the subject. However, apart from THC or CBD concentration, certain patients showed a preference for strains that had specific concentrations of some terpenes. Terpenes are molecules that also accumulate in the glandular hairs of the bracts of the female flowers and that, fundamentally, give the plant its smell and flavour. They are a fundamental component of essential cannabis oil, and more than of these compounds have been identified in the plant Brenneisen, The question that arises is whether this preference on the part of some patients is influenced only by these organoleptic characteristics of the plant, or whether there is really some type of therapeutic benefit associated with the presence of these molecules, both in quantity and variety. Today, we know that these compounds are also pharmacologically active and that, together with cannabinoids, they constitute the main secondary metabolites of cannabis, without forgetting phenols, which we will discuss later. These compounds are not exclusive to cannabis and they are also found as part of the essential oil of other plants. Their pharmacological potential has been analysed through preclinical and clinical studies, either with isolated terpenes or through essential oils with high concentrations of some of these compounds. For example, in laboratory animal studies, limonene showed anxiolytic, analgesic, anti-inflammatory, and antidepressant effects. This molecule contributes to muscle relaxation and aids sleep Baron et al. Linalool showed analgesic, anticonvulsant, and anxiolytic activity, while myrcene showed anti-inflammatory, analgesic, and anxiolytic activity. Therefore, terpenes show a multitude of pharmacological actions and, as there is a great variety of these compounds in cannabis, it cannot be ruled out that the aforementioned entourage effect , related to the synergy or antagonism of cannabinoids and terpenes, could explain the multi-target pharmacological effect. In addition, terpenes may also affect some pharmacokinetic aspects of THC, such as enhancing its bioavailability the amount of substance reaching systemic circulation through an increase in blood-brain barrier permeability Smith, , modulating the affinity of THC for the CB1 receptor, and interacting with receptors for certain neurotransmitters, which could explain how terpenes modulate the analgesic and psychotic effects mediated by cannabinoids McPartland and Russo, ; Russo, As for phenolic compounds, we can highlight the presence of different flavonoids, especially flavones and flavonols, such as apigenin, luteolin, kaempferol or quercetin, which are found both free and in the form of glycosides. In addition, there are two flavones exclusive to this plant: cannflavin A and B. Lignans and stilbenes are other phenols present in cannabis. Phenols in general are antioxidant compounds that help prevent numerous pathologies such as cardiovascular diseases, neurodegenerative diseases, or cancer Andre et al. These types of molecules are not only able to scavenge free radicals, especially reactive oxygen species, but also modulate the levels of cellular antioxidant enzymes Halliwell et al. Thus, for example, apigenin is anxiolytic, and together with other flavonoids present in cannabis shows a mild oestrogen effect, while, on the other hand, Cannflavin A is a potent inhibitor of prostaglandin E2 and of cyclo- and lipoxygenases, thus producing an interesting anti-inflammatory effect McPartland and Russo, Scientific evidence of cannabinoid-terpenoid interaction is scarce. Information mostly comes from dispensaries extolling the virtues of patented chemical strains of cannabis, or chemovars. However, as we have seen above, some terpenoids have intrinsic physiological effects, so the idea of a combined effect should not be ruled out. According to studies conducted by Santiago et al. This does not rule out the possibility of an entourage effect, since this interaction could occur by other means, such as acting on other proteins, affecting the metabolism and distribution of cannabinoids, interacting with G protein-coupled receptors, or with ligand-activated ion channels, among others. There are many other ways in which these molecules could interact with cannabinoids to influence the overall therapeutic and subjective outcomes of cannabis administration. We have reports of consumers with clear preferences for certain strains of cannabis, which could be explained by the entourage effect. However, these are personal experiences and we need scientific evidence. Researchers agree that THC is the compound with the greatest therapeutic value, but the use of the plant as a whole can be equally valuable. More studies are needed because, for example, we do not know in what concentration terpenes reach the central nervous system and the brain when cannabis is consumed. Studies are needed in which different types of cannabis are analysed, with different concentrations of terpenes and phenols, since, for the most part, the effect of the sum is studied by simultaneously administering various previously isolated compounds. It is difficult to find works in which a pharmacological analysis of various types of cannabis is combined with an exhaustive phytochemical analysis of the samples used, which makes it difficult to extrapolate the findings to the consumers' habitual usage. The final composition may depend to a large extent on processing conditions, for example, the evaporation rate of some components during these steps. Many of the available medical cannabis preparations, especially oils, show lower amounts of terpenes especially monoterpenes than the plant Eyalet al. To this should be added the fact that, given the existing legal situation, consumers patients or otherwise do not usually have a single source for the product, which makes it even more difficult to obtain reproducible effects. The forms of consumption also influence the availability of the different components; for example, if Cannabis is vaped, terpenes are inhaled before cannabinoids Eyalet al. On the other hand, in most of the studies, the composition of the different preparations of the plant is not detailed, being limited to expressions such as 'Cannabis extract' or 'Cannabis oil', which does not allow one to know the concentrations of the different components. Differences in processing and consumption methods make it extremely difficult to know, let alone predict, the importance of the effect of the various plant components on the final effect of medicinal cannabis. Therefore we could truthfully say that there is not a single entourage effect, but rather innumerable ones, depending on the presence and proportions of the various compounds due to the different forms of consumption. In summary, the use of the cannabis plant allows the joint action of several of its components, which could reveal beneficial effects that have not yet been scientifically demonstrated. The cultivation of specific varieties under controlled conditions humidity, temperature, soil, hours of light, etc. Thus, known and controlled compositions of terpenes, phenols, THC, CBD and other cannabinoids, as a whole, would give us the opportunity to profile more effective drugs, personalised for each patient's needs. Undoubtedly, taking advantage of the entourage effect would increase the pharmaceutical value of cannabis and justify the use of the plant over its isolated components. Andre, C. Frontiers in Plant Science 7. Baron, E. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. The Journal of Headache and Pain 19, Brenneisen, R. Humana Press, Totowa, NJ, pp. Cannabis Cannabinoid Res. Fischedick, J. Metabolic fingerprinting of Cannabis sativa L. Phytochemistry 71, — Flores-Sanchez, I. Secondary metabolism in cannabis. Phytochemistry Reviews 7, — Halliwell, B. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Harris, H. Cannabis and Cannabinoid Research 4, — Iseger, T. A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophrenia Research , — Johnson, J. Journal of Pain and Symptom Management 39, — Klein, C. Psychopharmacology Berl , — McPartland, J. Cannabis and Cannabis Extracts. Journal of Cannabis Therapeutics 1, — Raz, N. Molecules , 27, Romero-Sandoval, E. Cannabis and Cannabinoids for Chronic Pain. Current Rheumatology Reports 19, Russo, E. A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Medical Hypotheses 66, — Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology , — Santiago, M. Wagner, H. Synergy research: Approaching a new generation of phytopharmaceuticals. Phytomedicine 16, 97— Whittle, B. Wilsey, B. The Journal of Pain 14, — One of the hallmarks of the human race is our drive for happiness. Throughout evolution, we have Epilepsy affects 1. One third of those affected suffers from what is Decisions about cellular fate are key for correctly maintaining the cell environment and for the Skip to main content. Medicinal cannabis: Would using the plant have advantages over using the individual ingredients? Do terpenes contribute? Let's not forget phenols As for phenolic compounds, we can highlight the presence of different flavonoids, especially flavones and flavonols, such as apigenin, luteolin, kaempferol or quercetin, which are found both free and in the form of glycosides. Interactions of cannabinoids with other plant components Scientific evidence of cannabinoid-terpenoid interaction is scarce. Do the effects of medical cannabis vary according to the modified varieties ' cultivars ' and the manner of consumption? Bibliography: Andre, C. Transdermal Cannabinoid Patch. All information in our content is based on scientific studies. If you are considering using cannabis or cannabinoids to treat your symptoms or disease, please consult a medical professional first. The use of our content for commercial purposes is not permitted. No form of alteration, adaptation or translation of our content is permitted without prior agreement. In case of downloading and using our contents it will be exclusively for educational purposes and they must always be duly accredited. The publication of our contents is not allowed without express permission. More publications The pursuit of happiness and what cannabinoids have to do with it One of the hallmarks of the human race is our drive for happiness. Cannabis and the treatment of epilepsy Epilepsy affects 1. Cannabinoids and cellular fate in the brain Decisions about cellular fate are key for correctly maintaining the cell environment and for the

Buy marijuana online in Santander