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The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows. The review concludes with an outline for preparing cannabis dried inflorescence containing drug dosage forms that can be produced in a hospital pharmacy. Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice. Biomedical papers , 1 , Open full article. Hanus LO. Pharmacological and therapeutic secrets of plant and brain endo cannabinoids. Med Res Rev ;29 2 Go to original source Go to PubMed Laursen L. Botany: The cultivation of weed. Nature ; :S4-S5. Constituents of Cannabis sativa L. A review of the natural constituents. J Nat Prod ;43 2 Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L. Tetrahedron ;19 67 Cannabis in Eurasia: origin of human use and Bronze Age trans-continental connections. Vegetation History and Archaeobotany ;26 2 Zuardi AW. History of cannabis as a medicine: a review. Rev Bras Psiquiatr ;28 2 Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions. J Opioid Manag ;5 3 Gorji A, Khaleghi GM. History of headache in medieval Persian medicine. Lancet Neurol ;1 8 Kalant H. Medicinal use of cannabis: history and current status. Pain Res Manag ;6 2 Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia ;55 6 Phytocannabinoids: A Unified Critical Inventory. Natural Products Reports ;12 33 Elsohly MA, Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci ;78 5 The therapeutic potential of cannabis. Lancet Neurol ;2 5 Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol ; 7 Levine J. Origin of cannabinol. J Am Chem Soc ;66 11 Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc ;86 8 Notes on the structure of cannabidiol compounds. Mechoulam R, Shvo Y. The structure of cannabidiol. Tetrahedron ; Endocannabinoids: a unique opportunity to develop multitarget analgesics. Pain ; Suppl 1 SS Krejci Z, Santavy F. Mechoulam R, Parker LA. The endocannabinoid system and the brain. Annu Rev Psychol ; Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J ; 9 Mol Neurobiol ; 54 10 Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. Grotenhermen F. Cannabinoids and the endocannabinoid system. Cannabinoids ;1 1 Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther ;74 2 Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem ; 1 Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol ; 5 J Pharmacol ; 8 A new face of endocannabinoids in pharmacotherapy. Part I: protective role of endocannabinoids in hypertension and myocardial infarction. J Physiol Pharmacol ;65 2 Cannabidiol, a novel inverse agonist for GPR Biochem Biophys Res Commun ; 1 Experts' perspectives on the role of medical marijuana in oncology: A semistructured interview study. Psychooncology ; 26 8 Cannabidiol potentiates pharmacological effects of Delta 9 -tetrahydrocannabinol via CB 1 receptor-dependent mechanism. Brain Res ; Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol ; 4 The use of cannabinoids in animals and therapeutic implications for veterinary medicine: a review. Vet Med-Czech ;61 3 Front Pharmacol ; Nightingale SL. Dronabinol approved for use in anorexia associated with weight loss in patients with AIDS. JAMA ; 11 Marijuana-produced changes in pain tolerance. Experienced and non-experienced subjects. Int Pharmacopsychiatry ;10 3 Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Anesthesiology ; 5 Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. Neuropsychopharmacology ;38 10 Antinociceptive, subjective and behavioral effects of smoked marijuana in humans. Drug Alcohol Depend ;59 3 Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. BMJ ; Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology ;68 7 Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology ;34 3 A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. J Pain ;9 6 Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Cannabis use for chronic non-cancer pain: results of a prospective survey. Pain ; Prescribing smoked cannabis for chronic noncancer pain: preliminary recommendations. Can Fam Physician ;60 12 Hill KP. JAMA ; 24 Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials. Can Fam Physician ;61 8 :ee J Pain ;16 12 Kramer JL. Medical marijuana for cancer. CA Cancer J Clin ;65 2 Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Clin Pharmacol Ther ;55 3 Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. Neurology ;53 9 Cannabis use as described by people with multiple sclerosis. Can J Neurol Sci ;30 3 Patterns of cannabis use among patients with multiple sclerosis. Neurology ;62 11 The effect of cannabis on tremor in patients with multiple sclerosis. Neurology ;62 7 Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Mult Scler ;10 4 J Neurol Neurosurg Psychiatry ;83 11 The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases. Prog Neurobiol ; Medical uses of cannabinoids. Huestis MA. Human cannabinoid pharmacokinetics. Chem Biodivers ;4 8 Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol. Handb Exp Pharmacol ; J Anal Toxicol ;41 2 Am J Psychiatry ; 9 Two cases of 'cannabis acute psychosis' following the administration of oral cannabis. BMC Psychiatry ; Chemistry, metabolism, and toxicology of cannabis: clinical implications. Iran J Psychiatry ;7 4 Clin Chem ;55 12 Eur J Clin Pharmacol ;69 5 Safety and pharmacokinetics of oral deltatetrahydrocannabinol in healthy older subjects: a randomized controlled trial. Eur Neuropsychopharmacol ;24 9 Novel Delta 9 -tetrahydrocannabinol formulation Namisol R has beneficial pharmacokinetics and promising pharmacodynamic effects. J Clin Pharmacol ;74 1 Population pharmacokinetic model of THC integrates oral, intravenous, and pulmonary dosing and characterizes short- and long-term pharmacokinetics. Clin Pharmacokinet ;54 2 Population pharmacokinetics model of THC used by pulmonary route in occasional cannabis smokers. J Pharmacol Toxicol Methods ; Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. J Pharm Pharmacol ;40 5 Efficacy and safety of medical cannabinoids in older subjects: a systematic review. Ageing Res Rev ; The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. Int J Clin Pharmacol Ther ;34 10 Cannabinoids and Cytochrome P Interactions. Curr Drug Metab ;17 3 Decarboxylation of Delta 9 -tetrahydrocannabinol: Kinetics and molecular modeling. Journal of Molecular Structure ; Medicinal cannabis: Principal cannabinoids concentration and their stability evaluated by a high performance liquid chromatography coupled to diode array and quadrupole time of flight mass spectrometry method. J Pharm Biomed Anal ; Neurotherapeutics ;12 1 Return to the content.

Buy marijuana online in Olomouc