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Background: The current social and legal landscape is likely to foster the medicinal and recreational use of cannabis. Synthetic cannabinoid use is associated with acute kidney injury AKI in case reports; however, the association between natural cannabis use and AKI risk in patients with advanced chronic kidney disease CKD is unknown. Materials and Methods: From a nationally representative cohort of , U. The exposure of interest was cannabis use compared with no use as ascertained by the UTOX test. We examined the association of this exposure with AKI using logistic regression and inverse probability of treatment weighting with extensive adjustment for potential confounders. These results were robust to various sensitivity analyses. Additional studies are needed to characterize the impact of cannabis use on risk of kidney disease and injury. Keywords: acute kidney injury; cannabinoids; chronic kidney disease; end-stage kidney disease; multinomial propensity score weights; urine toxicology. Abstract Background: The current social and legal landscape is likely to foster the medicinal and recreational use of cannabis. Gov't, Non-P. Research Support, N.
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