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Submit to this Journal. Sign up for new issue notifications. Scilit database MDPI. Ulrich's Periodicals Directory. Dimension - Digital Science. Semantic Scholar - Allen Institute. Open Ukrainian Citation Index. The Lens. Microsoft Academic. Google Scholar. Genamics JournalSeek. Academic Journal Database. Citefactor Academic Scientific Journals. Directory of Research Journals Indexing. National Center for Biotechnology Information. Elektronische Zeitschriftenbibliothek EZB. Advanced Sciences Index. Index Copernicus. Publons - Web of Science Group. Kopernio - Web of Science Group. Mendeley - Elsevier. Analitika — 19th International exhibition for laboratory equipment and chemical reagents. Analytica Vietnam Designed assembly of colloids at interfaces - fundamentals to applications. Liberty Bell Corrosion Course. International Society of Electrochemistry — 72nd Annual Meeting. International Society of Electrochemistry — 74th Annual Meeting. In the present study we have determined the fundamental physico-chemical properties such as, ionization constant p K a and lipophilicity log P of some b-blockers and anti-diabetic drugs. Effect of temperature, ionic strength and dielectric constant on dissociation constant has been compared. The aqueous p K a values were then obtained by Yasuda-Shedlovsky extrapolation. In the case of water-soluble drugs Amiloride hydrochloride, metoprolol tartrate and propranolol hydrochloride , the extrapolated results were in good agreement with that of p K a values measured in aqueous solutions under the same experimental conditions, while for the water insoluble drugs atenolol, amlodipine besylate, gliclazide, glipizide, glibenclamide and pioglitazone , the extrapolated results were in good agreement with the literature values. For few of the selected drugs, the ps K a was determined spectrophotometrically and the results were compared with that of potentiometry in various co solvent mixtures. The measured log P values of selected drugs showed acceptable range to that of literature values. Citations \\\\\\\\\[1\\\\\\\\\]. Isabel B. Lima Effect of water content on the acid—base equilibrium of cyanidinglucoside Food Chemistry , , DOI: B 1 8 , , DOI: Wollatz, D. Haznar-Garbacz, U. Hanke, K. Box, R. Taylor, R. Ruiz, S. Beato, D. Becker, W. Jarukorn Sripradite, Susannah A. Miller, Michael D. Johnson, Anan Tongraar, Debbie C. Imad I. Tavakol Heidary Shayesteh, Moojan Radmehr, Farzad Khajavi, Reza Mahjub Application of chemometrics in determination of the acid dissociation constants pKa of several benzodiazepine derivatives as poorly soluble drugs in the presence of ionic surfactants European Journal of Pharmaceutical Sciences 69, 44, DOI: Samar H. Thiab, Imad I. Albert, A. Ramette R. Serjeant E. Qiang, Z. Water Res. Pool, S. A , , Erdemgil, F. Talanta , 72, Evagelou, V. Jimenez-Lozano, E. Acta , , Janos P. Andrasi, M. Wrobel, R. Meloun, M. Ying-Sing, F. Analyst , , Papanastasiou, G. Talanta , 36, Avdeef, A. Kin, T. Karl, B. Krisztina, T. Gergely, V. Acta , , — Avdeef A. Kraft, A. Tam, K. Ruth, A. Wishart, D. Arnaud-neu, F. Pure Appl. Gutmann, V. Loudon, G. Organic Chemistry, 4th edition, Oxford University Press, Coetzee, J. Absorption and Drug Development. The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author s , and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees. All rights reserved. Registered in USA. European Journal of Chemistry. Current Issue. Journal Help. User Username Password Remember me. Notifications View Subscribe. Font Size. Article Tools Print this article. Indexing metadata. How to cite item. Email this article Login required. Email the author Login required. Hide Show all. Physico-chemical characterization of some beta blockers and anti-diabetic drugs - potentiometric and spectrophotometric pKa determination in different co-solvents. Abstract In the present study we have determined the fundamental physico-chemical properties such as, ionization constant p K a and lipophilicity log P of some b-blockers and anti-diabetic drugs. Full Text: PDF. References \\\\\\\\\[1\\\\\\\\\]. Narasimham, L. Remember me.
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