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Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. This sheet is about exposure to MDMA in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider. If you have been using MDMA, please seek help right away. Treatment is available to help you stop using MDMA. Talk with your healthcare providers; they are there to help you. How long does the drug stay in my body? People eliminate drugs at different rates. In healthy adults, it takes up to 4 days, on average, for most of the MDMA to be gone from the body. Miscarriage is common and can occur in any pregnancy for many different reasons. Studies have not been done to see if MDMA increases the chance for miscarriage. This is called the background risk. Based on the studies reviewed, it is not known if MDMA increases the chance for birth defects above the background risk. However, it is not known if the MDMA or other factors caused the increase in birth defects. Does taking MDMA in pregnancy increase the chance of other pregnancy-related problems? Based on the studies reviewed, it is not known if MDMA can cause other pregnancy-related problems, such as preterm delivery birth before week 37 or low birth weight weighing less than 5 pounds, 8 ounces \[ grams\] at birth. Based on the studies reviewed, it is not known if MDMA increases the chance for behavior or learning issues. A study of twenty-eight pregnancies exposed to MDMA reported infants showed a delay in development at four months old. Another study followed a small group of children exposed 1 month before pregnancy and in the first and second trimesters. The study suggested that babies exposed to MDMA might be delayed in their motor development up to 2 years of age. However, the people who were pregnant also reported exposure to alcohol and other drugs. This makes it hard to know if the MDMA, other exposures, or other factors caused these delays. Breastfeeding while using MDMA is not recommended. MDMA passes into breast milk. Amphetamine drugs like MDMA are found at higher levels in breastmilk than in the blood stream. If MDMA has already been taken, it has been recommended to express and discard breast milk for 48 hours. Be sure to talk to your healthcare provider about all of your breastfeeding questions. If a male takes MDMA, could it affect fertility ability to get partner pregnant or increase the chance of birth defects? Studies have not been done to see if MDMA could affect male fertility or increase the chance of birth defects above the background risk. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy. While our name still contains a reference to mothers, we are updating our resources with more inclusive terms. Use of the term mother or maternal refers to a person who is pregnant. Use of the term father or paternal refers to a person who contributes sperm. Turn recording back on. Help Accessibility Careers. Search term. Selected References: Barenys M. Toxicol Lett \[ PubMed : \]. Barneys M, et al. Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Nurotoxicology Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics J Accid Emerg Med 14 3 Draper ES, et al. Recreacional drug use. A major risk factor for gastroschisis? Am J Epidemiol 4 A comprehensive review of assay methods to determine drugs in breast milk and the safety of breastfeeding when taking drugs. Anal Bioanal Chem— Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults. Ther Drug Monit. Jun;30 3 Marcela C, et al. Stimulant use in pregnancy — An under-recognized epidemic among pregnant women. Clin Obstet 62 1 McElhatton P, et al. Congenital anomalies after prenatal ecstasy exposure. Lancet Parrott A, et al. MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used 'Ecstasy' during pregnancy. Hum Psychopharmacol 29 1 Plessinger M, Prenatal exposure to amphetamines. Risks and adverse outcomes in pregnancy. Obstet Gynecol Clin North Am Singer LT, et al. Neurobehavioral outcomes of infants exposed to MDMA Ecstasy and other recreational drugs during pregnancy. Neurotoxicol Teratol 34 3 Singer L. One-year outcomes of prenatal exposure to MDMA and other recreational drugs. Pediatrics 3 : — Developmental outcomes of 3,4-methylenedioxymethamphetamine ecstasy -exposed infants in the UK Hum Psychopharmacol 30 4 : Motor delays in MDMA ecstasy exposed infants persist to 2 years. Neurotoxicol Teratol Smid MC, et al. Stimulant use in pregnancy: An under-recognized epidemic among pregnant women. Clin Obstet Gynecol 62 1 Ned Tijdschr Geneeskd 1 Stimulants: How big is the problem and what are the effects of prenatal exposure? Semin Fetal Neonatal Med 24 2 Related information. Recent Activity. Clear Turn Off Turn On. Follow NCBI.

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