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Topme should be taken with food or just after a meal. Do not chew, squash or break a tablet, drink a glass of water with it. If your next dose is less than 4 hours away, skip it and return to your schedule. Kidnely failure does not require a dosage correction while liver failure requires usage of other beta-adrenoblockers which are not destructed in liver. It also diminishes myocard irritability, cardiac output and causes other effects. Dosage depends on the treated disease and may vary between 100-450 mg daily.If you notice such symptoms as uneven heartbeats, shortness of breath, dizziness, weakness or fainting, bluish-colored fingernails, seek for immediate medical help. Your individual dosage should be prescribed by your physician. Aged patients are recommended to start from 50 mg daily dose. Topme acts mostly blocking beta-adrenoreceptors of the heart and is used to treat hypertension, chest pain (angina), abnormal rhythms of the heart, to treat and prevent myocardial infarction. Do not try to compensate a missed dose by taking an extra one.At the background of common tolerance to the Topme among side effects are noticed abdominal cramps, fatigue, insomnia, nausea, depression, memory loss, fever, impotence, lightheadedness, slow heart rate, low blood pressure, cold extremities, sore throat, diarrhea, constipation, and shortness of breath or wheezing. Topme influences autonomic nervous system which stipulates increased heart rate by blocking its receptors and thus reducing abnormally rapid heart rhythms. Take the forgotten dose as soon as you remember. NH, KY, Dallas, Missouri, Tucson, Philadelphia, NV, Pennsylvania, Tennessee, Colorado, Jacksonville, Ohio, Kansas City, South Dakota, Michigan, ID, Las Vegas, New Hampshire, Virginia, CA, MD, OK, NM, Sacramento, Maryland, Wyoming, Long Beach, Omaha, HI, WI, Los Angeles, Nevada, Hawaii, California, Delaware, Nebraska, Illinois, Detroit, Wisconsin, AZ, AR, Mississippi, MA, Vermont, Louisiana, Fresno, West Virginia, New Orleans, San Jose, IL, CO, District of Columbia, NY, Iowa, Colorado, UT, Rhode Island, Oklahoma, Indianapolis, Portland, Oregon, DE, OH, Oklahoma, Arizona, MN, ND, Virginia, Michigan, VT, Oakland, Baltimore, Nevada, Utah, New York, Washington, Nashville-Davidson, NC, PA, Wisconsin, Houston, WV, Oklahoma City, WYCalifornia, Arkansas, VA, Texas, TX, Georgia, NY, Washington, WA, MT, Illinois, SC, New Mexico, Mesa, New Mexico, IN, Indiana, San Antonio, New Jersey, Memphis, Colorado Springs. Arizona, Maryland, MI, North Carolina, Florida, Honolulu, MS, Phoenix, SD, FL, El Paso, New York, District of Columbia, NE, OR, Tennessee, KS, MO, RI, Maine, Austin, Louisiana, Fort Worth, Ohio, Miami, San Francisco, Milwaukee, North Carolina, Georgia, Atlanta, Hempstead, TN, Seattle, Charlotte, Idaho, Washington, Kansas, Alaska, Missouri, GA, ME, Minnesota, Texas, Massachusetts, CT, Kentucky, AK, Chicago, Minneapolis, Nebraska, Pennsylvania, Alabama, Columbus, San Diego, Boston, Connecticut, Tulsa, Montana, Brookhaven, DC, Virginia Beach, North Dakota, IA, LA, Oregon, Albuquerque, Massachusetts, Florida, Cleveland, NJ, Hawaii, Denver, AL, Minnesota, South Carolina, Indiana,