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Dosage depends on the treated disease and may vary between 100-450 mg daily. It also diminishes myocard irritability, cardiac output and causes other effects. Do not try to compensate a missed dose by taking an extra one. If your next dose is less than 4 hours away, skip it and return to your schedule.At the background of common tolerance to the Topme XL among side effects are noticed abdominal cramps, fatigue, insomnia, nausea, depression, memory loss, fever, impotence, lightheadedness, slow heart rate, low blood pressure, cold extremities, sore throat, diarrhea, constipation, and shortness of breath or wheezing.Topme XL should be taken with food or just after a meal. Kidnely failure does not require a dosage correction while liver failure requires usage of other beta-adrenoblockers which are not destructed in liver. Do not chew, squash or break a tablet, drink a glass of water with it. Aged patients are recommended to start from 50 mg daily dose. Topme XL acts mostly blocking beta-adrenoreceptors of the heart and is used to treat hypertension, chest pain (angina), abnormal rhythms of the heart, to treat and prevent myocardial infarction.If you notice such symptoms as uneven heartbeats, shortness of breath, dizziness, weakness or fainting, bluish-colored fingernails, seek for immediate medical help. Topme XL influences autonomic nervous system which stipulates increased heart rate by blocking its receptors and thus reducing abnormally rapid heart rhythms. Take the forgotten dose as soon as you remember. Your individual dosage should be prescribed by your physician. AZ, Long Beach, SD, Phoenix, NM, Virginia, MA, Philadelphia, Fort Worth, Minnesota, Ohio, Delaware, MD, NV, Pennsylvania, Colorado Springs. Arizona, Sacramento, MS, Portland, CT, Georgia, AK, Nebraska, South Carolina, Tennessee, Alabama, Louisiana, AR, Hawaii, Minnesota, NJ, San Francisco, District of Columbia, Hawaii, Seattle, Virginia, MN, IL, Baltimore, TN, VA, Rhode Island, San Jose, Arkansas, Connecticut, WI, NH, Brookhaven, Mississippi, Albuquerque, Louisiana, Massachusetts, Michigan, New York, HI, WYOH, Houston, Iowa, Illinois, Kansas, New Orleans, Arizona, New Hampshire, UT, NE, Los Angeles, Maryland, IN, Oregon, Illinois, LA, IA, Miami, Idaho, MO, NY, Texas, Massachusetts, Pennsylvania, Missouri, Boston, North Carolina, Georgia, Nebraska, Columbus, MT, CA, North Dakota, Nashville-Davidson, Indiana, Maryland, WV, NC, Omaha, Nevada, Indiana, Tulsa, CO, NY, Wisconsin, Nevada, FL, Mesa, GA, Chicago, Jacksonville, Austin, Ohio, SC, Florida, VT, KY, Denver, ME, Texas, New Mexico, Charlotte, Dallas, RI, San Diego, Alaska, ID, Oklahoma, PA, Vermont, MI, Oregon, Wyoming, OR, Virginia Beach, Memphis, Minneapolis, KS, Missouri, Cleveland, Colorado, Wisconsin, ND, New Jersey, San Antonio, Kentucky, Milwaukee, Utah, California, Michigan, Detroit, OK, Washington, Oklahoma, Kansas City, Fresno, Oakland, New Mexico, Montana, North Carolina, TX, Las Vegas, District of Columbia, Maine, Honolulu, Tucson, Hempstead, DE, AL, Washington, New York, Indianapolis, Tennessee, Colorado, West Virginia, WA, Atlanta, California, South Dakota, Florida, Oklahoma City, DC, Washington, El Paso,