Buy Phenacetin Crystal and Powder (CAS 62-44-2) Wholesale

Buy Phenacetin Crystal and Powder (CAS 62-44-2) Wholesale

Phenacetin Overview:

Name: Phenacetin
CAS No.: 62-44-2
Molecular Formula: C10H13NO2
Molecular Weight: 179.22 g/mol
Appearance: White powder or crystals
Purity: Typically 99% or higher
Storage: Powder should be stored at -20°C for up to 3 years; solutions should be stored at -80°C for 6 months.

Uses:

Historical Use: Initially used as a pain reliever and fever reducer. It was popular in combination analgesics, such as A.P.C. (aspirin-phenacetin-caffeine) tablets.
Current Use: Phenacetin is primarily used as a research chemical. It serves as a probe for cytochrome P450 enzymes, particularly CYP1A2.

Mechanism of Action:

Phenacetin is a selective COX-3 inhibitor and exhibits analgesic (pain-relieving) and antipyretic (fever-reducing) properties.

Health Concerns:

Carcinogenicity: Phenacetin is classified as a carcinogen. Long-term use has been linked to urothelial carcinoma and renal issues.
Side Effects: This can cause kidney damage, hemolysis in some individuals, and other adverse effects.

Purchase Information:

Factory Price: Prices vary depending on purity, quantity, and supplier. Contact suppliers for quotes.
Availability: Can be purchased from chemical suppliers, online marketplaces, and specialized chemical providers.

Suppliers:

China: Numerous suppliers offer Phenacetin in both crystal and powder forms. They often provide competitive pricing and bulk purchasing options.
Online Platforms: Look for reputable suppliers on platforms like ChemicalBook, Amazon, and LinkedIn.
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Packaging and Delivery:

Packaging: Available in various sizes such as 1 kg foil bags or drums, depending on supplier capabilities.
Delivery: Typically ships within 7 days of payment. Shipping methods include air, sea, or other preferred methods.

Ordering Tips:

Verify Supplier: Ensure the supplier is reputable and can provide necessary documentation and safety data.
Specify Needs: Clarify purity requirements, quantity, and packaging preferences.
Check Regulations: Ensure compliance with local regulations regarding the purchase and use of Phenacetin.

Additional Information:

Safety: Due to its carcinogenic properties, handle Phenacetin with care and follow safety guidelines.

Synthesis methods

1. Vortex hydrochloric acid method

Phenacetin Crystal can be synthesized by vortex hydrochloric acid method. The method obtains cumene chloride by reacting cumene with hydrochloric acid, and then reacts cumene with methyl-p-phenylenediamine to obtain N-isopropyl-N-(4-methylaminophenyl) formamide, Finally Phenacetin is obtained by heating and adding base. The following are the specific steps:

Step 1: Reaction of cumene and hydrochloric acid: cumene and hydrochloric acid react in the presence of sulfuric acid to produce cumene chloride.

C6H5CH(CH3)2 + HCl → ClC6H4CH(CH3)2

Step 2: Reaction of cumene and methyl-p-phenylenediamine: reaction of cumene and methyl-p-phenylenediamine in tetrahydrofuran to generate N-isopropyl-N-(4-methylaminophenyl) Formamide.
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ClC6H4CH(CH3)2 + C6H4(NHCH3)2 → HCl + C6H4(CONH(CH3)C6H4NH2)

Step 3: Heating and base treatment: N-isopropyl-N-(4-methylaminophenyl)formamide is heated and base is added to obtain Phenacetin.

C6H4(CONH(CH3)C6H4NH2)+ NaOH → C6H4(CONH(CH3)C6H4NH2)Na + H2O

C6H4(CONH(CH3)C6H4NH2)Na + CH3CO2H → C6H4(CONH(CH3)C6H4NH2)H + NaOAc

C6H4(CONH(CH3)C6H4NH2)H → C6H4(O)NH(C2H5) + CH3CO2HC2H5

2. Reaction injection method

The reaction injection method is a simple and efficient method for the synthesis of Phenacetin. It uses phenol and N-acetylacetonolamine as raw materials to prepare Phenacetin Crystals by reaction injection. The following are the specific steps: