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Psychoactive agents in psychotherapy: New MDMA variants identified for potentially safer use

Buy MDMA pills Vienna

Vienna, The use of the active ingredient 3,4-methylenedioxy-N-methylamphetamine MDMA , commonly known as 'ecstasy', to support psychotherapy for mental illnesses such as post-traumatic stress disorder is being discussed worldwide. While the therapeutic potential of the substance has already been investigated in clinical trials, only Australia and New Zealand have so far decided to approve and restrict its controlled use by experts due to possible risks and side effects. An international research team led by MedUni Vienna has now identified three new variants of MDMA as promising alternatives for safer use in a controlled psychotherapeutic setting as part of a study. The results were recently published in the 'Journal of Neurochemistry'. As the studies carried out on human cell cultures by Harald Sitte's team from MedUni Vienna's Center for Physiology and Pharmacology and Center for Addiction Research AddResS show, the new chemical compounds have a similar effect to MDMA on the relevant clinical target structures in the brain such as serotonin, dopamine and noradrenaline transporters , which are crucial for regulating mood and emotion. In contrast to MDMA, however, the new substances have lower activity at certain serotonin receptors and are also broken down more favorably, resulting in fewer toxic breakdown products: 'This allows the conclusion that both the acute and long-term side effects of ODMA, TDMA and SeDMA may be lower than those of the conventional substance,' explains study leader Harald Sitte. The psychoactive substance MDMA 3,4-methylenedioxy-N-methylamphetamine has been known as the party drug 'ecstasy' since the s - although the first patent for the substance was granted back in Due to its effect of promoting positive emotions and increasing interpersonal empathy, research in recent years has focused on the potential of MDMA to support psychotherapy for various mental illnesses. However, possible risks and side effects tachycardia, high blood pressure, liver and nerve damage have so far been an obstacle to its widespread therapeutic use. The MDMA analogs currently identified may provide promising alternatives: 'Our experimental results showed that the new variants can retain the therapeutic potential of the conventional substance, but are likely to cause fewer side effects. At the same time, the psychopharmacologist and addiction researcher emphasizes the need for further studies to comprehensively test the efficacy and safety of MDMA variants for use in a psychotherapeutic setting, for example in the treatment of post-traumatic stress disorder. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte Doi: We use cookies that are technically necessary for the functionality of our website, but also cookies for functional, marketing and analysis purposes to optimise the user experience on our site. With your consent to the cookies, data is processed both by us and by third-party providers, some of which are based in third countries e. You can find more information about the tools and the partners in our data protection declaration, in which we also explain exactly what data transfer to the USA can mean. You can individually adjust or revoke your cookie settings at any time if you wish. These cookies are necessary for the basic functions of the website. You can block or delete them in your browser settings, but you then run the risk that some parts of the website will not function properly. To track users on your website s or app s , the default Matomo Tracking code in JavaScript uses 1st party cookies, which are set on the domain of your website. Deutsch close. All News. We use cookies. Data privacy. Technically required System These cookies are necessary for the basic functions of the website. Matomo To track users on your website s or app s , the default Matomo Tracking code in JavaScript uses 1st party cookies, which are set on the domain of your website. Allow all services. Reject all services. Save settings.

Buy MDMA pills Vienna