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Exposure therapy is known to be an effective treatment for anxiety disorders. Nevertheless, exposure is not used as much as it should be, and instead patients are often given supportive medications such as serotonin reuptake inhibitors SSRIs and benzodiazepines, which may even interfere with the extinction learning that is the aim of treatment. Thus, MDMA has a combination of pharmacological effects that, in a therapeutic setting, could provide a balance of activating emotions while feeling safe and in control, as described in case reports of MDMA-augmented psychotherapy. Further clinical and preclinical studies of the therapeutic value of MDMA are indicated. Abstract Exposure therapy is known to be an effective treatment for anxiety disorders. Publication types Research Support, Non-U. Substances N-Methyl-3,4-methylenedioxyamphetamine.