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Can Psychedelics Cure?

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Adjust the colors to reduce glare and give your eyes a break. Use one of the services below to sign in to PBS:. You've just tried to add this video to My List. But first, we need you to sign in to PBS using one of the services below. You've just tried to add this show to My List. By creating an account, you acknowledge that PBS may share your information with our member stations and our respective service providers, and that you have read and understand the Privacy Policy and Terms of Use. We can remove the first video in the list to add this one. We can remove the first show in the list to add this one. Matters of the Mind with Dr. Jay Fawver. Season Episode 27m 33s Video has closed captioning. Hosted by Dr. Jay Fawver, Matters of the Mind airs Mondays at pm. Problems Playing Video? Report a Problem Closed Captioning. Before you submit an error, please consult our Troubleshooting Guide. Your report has been successfully submitted. Thank you for helping us improve PBS Video. Open in new tab. Welcome to Matters of the Mind now entering its twenty sixth year Matters of the Mind is a live call in program where you have the chance to choose the topic for discussion. So if you have any questions concerning mental health issues, give me a call here at PBS Fort Wayne by dialing in the Fort Wayne area 27 two zero or if you're calling a place coast to coast you may dial toll free at to seven to zero now on a fairly regular basis we are broadcasting live every Monday night from our spectacular PBS Fort Wayne studios which lie in the shadows of the Purdue Fort Wayne campus and if you'd like to contact me with an email question that I can answer on the air, you may write me via the Internet at matters of the mind all one word atwa dot org that's matters of the mind at WFB. Eager to start tonight's program with a question I recently received it reads You're not your father. Back in the old days children and their parents had to write letters back and forth and that might be once a week once a month now you can communicate back and forth almost day to day to keep a really close eye on them. I don't know if I trust therapists or some of the colleges but in your local community you have more established therapists who have been around hopefully for a longer period of time and have greater connectivity that way. The next key would be would be to encourage your child to establish a very strong and healthy social network at school. Sometimes you can get kind of tough and the child might start avoiding classroom activity because it's getting kind of strenuous and it's getting stressful. Once the child starts avoiding classroom activity it tends to go downhill from there and then you find that they have trouble that first semester to which are highly critical for the child's success. But most importantly I tell this to all adolescents going off to college to say stay away from marijuana and stay away from alcohol. It'll be all over the place no matter almost what campus you will attend, you will find ready access to alcohol and marijuana and marijuana makes you not care. It makes you calmer and it makes you less stressed out about different things and a lot of people are using it. But the problem is it's highly predictive that the use of marijuana and alcohol especially that first semester and then going on to that first year can be predictive of your dropping out of school. So I'd make those recommendations at this point but make sure the child has some connectivity locally with a trusted therapist or a clinician who might be able to prescribe the child your child the medication that he or she needs that the most important thing will be to have some kind of therapeutic support back home. What are the Rad's rapid acting antidepressants, the rapid acting antidepressants or what are called Arad's? The Rad's will likely the ones you might be thinking of and from Australia are these hallucinogens or the psychedelic? These are medications that basically will stimulate a part of the brain very uniquely unlike the medication we've been using for the past 60 years that will primarily affect serotonin, norepinephrine and dopamine. The Rad's or the rapid acting antidepressant medications will affect this particular receptor called of mice kinase B receptors not my myson kinase B receptors upon stimulation will drastically start to affect the scaffolding of the nerve growth. So if your neurons should have one hundred thousand branches on them, maybe they'll shrivel up and shrivel up and only have sixty or seventy thousand branches will upon the stimulation of mice some kinase B receptors you will have kind of an influx of this Miracle-Gro type of effect, this growth factor for the scaffolding and the branching out of the individual neurons. They can work within a matter of minutes to ours and we've had some experience with Araz already with ketamine being used. I've primarily over the past twenty years for depression and people had dramatic effect with ketamine and then over the past four years we've had ketamine also known as bravado that is approved by the Food and Drug Administration as a nasal spray and we often see results with that within a week or so we've had more recently the psychedelics coming out the which include MDA MDMA which is methylene deoxy methamphetamine and that's a medication that upon taken at the appropriate doses allow a person allows a person to have a greater degree of self-awareness and more empathy for other people. People use it for a high on the street but under a very controlled therapeutic setting at the proper dosing it can be very quick acting for the treatment of depression. It's thought that it's roughly a thousand times more potent on that particular receptor than even ketamine. For the past six decades we've had medications that are primarily affecting serotonin, norepinephrine and dopamine and it takes weeks for those medication to go to work and people might have a partial response. They might have a high relapse rate with ketamine, with ketamine and with these psychedelics and hallucinogens coming out, it's hope that we can have a faster onset of action and more persistent retention of the of the improvement over the course of time. It combines bupropion which is also known as Wellbutrin in addition to dextromethorphan which is approved in as a cough suppressant. That combination dramatically increases the blood levels of dextromethorphan such that you can get some stimulation very quickly at that trouble Myson Kinase B receptor site and get a quick onset of action. So as an oral medication with all Valide we have sound we have found that people often will have a nice response with that within a couple of weeks as opposed to waiting several weeks. It's not as potent as ketamine or ketamine but it's something that also can give a fairly quick response. Kyle, you mentioned you'd wondered seasonal depression is limited only to the winter or can you have symptoms in the summer? So when people have seasonal affective disorder also known as winter depression quite commonly seasonal affective disorder is usually influenced by the darkness of the skies. Women are around four times more likely to have winter depression or seasonal affective disorder compared to men that's thought to be related to the fluctuations in estrogen and progestin and the treatment for it will be number one try to exercise number to try to socialize even they don't like to if you have winter depression you can also sit in front of Bright Light Box in October , November, December, January especially for maybe thirty minutes first thing in the morning we do give medication for winter depression such as Wellbutrin or Blueprint which I just mentioned which is a component of ability which could probably be used for winter depression as well. But the idea is to allow people to be more functional, be more active, be more socially interactive. If you stimulate that receptor you thereby stimulate the growth factors which can act as the scaffolding for a little neurons out there and make a more fluffy and make it more branched. I mean I have seizures but she has seizures that are costing and she finally went in to the doctor. But I know from my neurologist that if you have so many rich your neurons in your brain because I have seizures since I was a fetus. My girlfriend's daughter does can you get your neurons to get fixed or no, that's an excellent question, Sarah. What'll happen is that particular electrical circuit can blow a Fuze or just cause excessive electricity and you can start a fire unless you have a circuit breaker. So as I mentioned before, individual neurons might have up to one hundred thousand branches and if you have persistent seizures you're going down to maybe eighty thousand branches, sixty thousand branches and so forth. Yes, because we're finding that with some these so-called rapid acting antidepressant medications there is the potential for branching and growth of that branching with a matter of days in many cases. So if people have traumatic brain injury, if they have a history of stroke, if they have evidence of neurotoxicity the brain where they've had a frying of those branches, I think as time goes on we're going to be hearing more about the use of antidepressant medications that are these rapid acting antidepressant medications being used directly as a means of trying to regrowth those parts of the brain. But the key with seizures will always be we want to get him in control seizures like psychosis for that matter recurrent psychosis can do the same thing. For instance, if somebody has recurrent psychosis where they're losing touch with reality, they actually have a shrinkage of various parts of the brain. They're less fluffy intellectually cause the gray matter of the brain to kind of shrink down so that's why we want to get seizures and psychosis in good control and the big key over the next five years or so will be how can we regrow the brain rapidly? And I think with these rapid acting antidepressant medications that directly stimulate the regrowth of the branches of the brain, they might have potentials and many, many different areas in the future. Autistic disorder is a developmental condition that starts in childhood and it starts in childhood in such a way that you can have decreased activity in this right front part of the brain that allows you to have social connectedness and that's often a key factor for autism. You have difficulty mirroring the actions of others and picking up on the interpersonal communication from other people and that can often lead to a lack of empathy and a lack of awareness of how other people might be feeling and you have a hard time empathizing or putting yourself in their position. So usually, you know, autism comes along with many other conditions autism and attention deficit disorder often go hand in hand because with autism people can have difficulty with attention span distractibility focus with both aid and autism people often have difficulty with frustration tolerance. So instead of getting angry and getting irritable, you talk about how you're feeling at the time and you try to redirect your your attention to more productive types of way of ways of handling the stresses. Let's go our next email our next email reads Dear Dr. Farber, what works better ketamine or the nasal spray? And could the Food and Drug Administration approve a medication like ketamine that could be regulated and closely monitored and very importantly it would be paid for different by the different payers. So with that being said, the ketamine which is the left sided piece of ketamine, there's a left sided piece of ketamine and a right a piece of ketamine is ketamine was developed as a nasal spray, as a nasal spray. It was always frustrating for us now some people and many people do well with those medications ongoing but sometimes a little stress in their lives. A puff of smoke might get that fire going sometimes stress can do that when somebody had a recurrent depression over the course of time. They did affect that type of and kinase B receptor indirectly it would take them a long time to do it and they wouldn't do it as potently. So with ketamine as ketamine dextromethorphan which is in our ability and with the psychedelics in hallucinogenics they're affecting that receptor very profoundly very quickly. He took it himself and cocaine is properly used in their early 20s, early twentieth century but it's just not a good type of treatment for people because it's not affecting that dopamine kinase B receptor is primarily affecting dopamine norepinephrine. But the fact that you're starting a new work project number one, you're under pressure when you're under pressure there's a whole different part of your brain that kicks in when you're just doing day to day projects. This is the part of the brain that you use to pay attention to things that aren't particularly interesting and you persevere. The nucleus Cummins is down here in the middle part of the brain and that part of the brain is firing up dopamine and you're getting a lot of energy because you're under pressure and your heart rate will go up. You might feel a little bit more anxious if might feel like you have a lot of extra coffee on board. You can't sleep because you're really fired up to get this project so you'll have a lot of energy and you can't sleep because you want to get the project done. Not a big problem unless it gets to the point where that high energy and difficulty with sleep leads into what's called functional impairment where you can't go to work the next day you can't concentrate your sleep deprived. But if you can do this in spurts of activity where you have a lot of energy, you don't sleep for maybe one or two nights and then you get your work done and you're able to go to sleep the next night, that's fine. That works out OK but people will often have a lot of energy and they can't sleep when they need to get projects done whether and when they have a deadline coming up now better yet, Angie, what you want to do is try to stay on time and do it gradually over the course of time and not feel like you have to get it done all at once. Hey, if you get ahead of the deadline and you're done a week early, that's even better because here your main project is done. Unfortunately I don't mind I'm out of time for this evening and if you have any questions concerning mental health issues that I can answer on the air, you may write me via the Internet at matters of the mind all one word at WWE Dog psychiatrist Jay Fawver and you've been watching Matters of the Mind on PBS Fort Wayne God willing on willing. Skip to Main Content. Use System Theme. Dark Theme. Light Theme. Continue Watching. Watch Now. Professor Henry Louis Gates, Jr. Passport Highlights. Appearance Adjust the colors to reduce glare and give your eyes a break. You have the maximum of videos in My List. You have the maximum of shows in My List. Embed Video. Jay Fawver July 24, Season Episode Width: in pixels px Height: in pixels px. Copy Copied! Copy failed. Please try again. Report a Problem. Cancel Submit Report. Parkview Behavioral Health. My child is starting college in the fall but struggles with their mental health. Such that you can communicate with them by text, by emails you can maintain regular contact. Communicate with your child in therapy by telehealth. Now you can go to the campus itself, the college campus and be seen by therapists there. I strongly encourage the child to go to class. Let's go to our next question. Let's go next email. I thought they were legalized in Australia. They work very fast. Psilocybin is getting approved over in Australia right now. Psilocybin also effects that tobramycin kinase B receptor very, very quickly. They're not expected to be available maybe until the summer of twenty twenty four. But it's a different time in psychiatry. Let's our next caller hello Kyle. That's very, very rare. Thanks for your question. Hello Sarah. Welcome to Mastermind. Hello Sarah this is Jerry. I apologize for you sir. Okay I have a question. My girlfriend's daughter has seizures. So I was just wondering if you constantly have seizures all the time. Keep it in mind glutamate is an excitatory chemical in the brain. It's going to the television set, the space heater, the ion all these different circuits. Can you bring that back? There is a damaging effect on the brain. It's not that the neurons nerve cells are dying. It's just that they're becoming less branched. Let's go our next caller. Hello Margaret. Welcome to Matters of Mind. Not typically, Margaret. I'm trying to figure out which one to use. Ketamine has been around since nineteen seventy as an anesthetic as an anesthetic. It gets absorbed very well in the nasal passages and as ketamine is trade name is bravado. But at about the four week mark or the six week mark they're both working about the same. So getting a very quick very quick onset of action. But the problem is it's primarily affecting dopamine, norepinephrine. Sigmund Freud one hundred years ago actually prescribed it. Thanks for your call. Let's go to next caller. Hello Angie. It's called the dorsolateral prefrontal cortex. You keep working at it and you get things done using the left front part of your brain. They get really excited about it. You've got a week to go. You kind of think about the project over that subsequent week, make some minor refinements. Thanks for watching. You Might Also Like.

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