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Drugs were given at an ambient temperature of 28 degrees C to simulate hot nightclub conditions. Body temperature, locomotor activity and head-weaving were assessed during acute drug administration while social interaction, anxiety-related behavior on the emergence test and neurochemical parameters were assessed weeks later. Conclusions: These results suggest that MDMA and METH in combination may have greater adverse acute effects head-weaving, body temperature and long-term effects decreased social interaction, increased emergence anxiety, dopamine depletion than equivalent doses of either drug alone. Publication types Research Support, Non-U.
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