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Items in Media are protected by copyright, with all rights reserved, unless otherwise indicated. File Description Size Format MDMA 3,4-methylenedioxymetamphethamine, ecstasy is one of the most popular illicit recreational drugs among young adults. However, the underlying neurobiological mechanisms responsible for the physiological, behavioural and psychological effects, as well as the influence on cognitive functions such as memory and decision making are still not fully examined. Furthermore, if and to what extend this drug has neurotoxic properties is debated. Most ecstasy users are polydrug users, and the majority concomitantly consumes cannabis. Cannabis is the most frequently consumed illegal psychoactive drug world wide. While cannabis products are generally perceived as soft drugs and their potential medical usefulness is progressing, cognitive impairments and long-term alterations in the brain, especially following prolonged and heavy use in adolescence, are observed. This thesis investigates the influence of MDMA and the synthetic cannabinoid receptor agonist, WIN55, WIN , on different forms of decision making, memory function, locomotor activity and physiological parameters such as body temperature and food intake. Within both an acute as well as chronic systemic administration schedule, effects of each substance alone as well as their combination is tested in order to mimic co-consumption of these drugs. Within chronic treatment, adult as well as pubertal rats and their respective brain myelination levels are examined to determine vulnerable periods of drug consumption or age-related differences. Page view s Download s Google Scholar TM Check. Schulz, Sybille. Koch, Michael. Dicke, Ursula.

COVID-19 and Brexit ‘caused sharp rise in copycat ecstasy’, study suggests

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A new study has highlighted the apparent effect of Brexit and the pandemic on the trade in the illegal party drug ecstasy MDMA. Then, as UK nightlife re-opened ahead of other European countries, demand outpaced supply. This was compounded by Brexit-related supply chain disruptions affecting distribution. During this unprecedented turbulence in the drug market, substances that look like MDMA were mis-sold to unknowing customers. The Loop operates a pop-up laboratory which analyses substances of concern. Monitoring changing drug trends allows The Loop to provide information and rapid alerts, including to festival paramedics and the general public, for the purposes of harm reduction. Yet, while virtually absent in , synthetic cathinones and caffeine each constituted approximately a fifth of MDMA samples. Synthetic cathinones are chemical cousins of amphetamines e. In , shortly after the banning of mephedrone, methylone made its debut on the UK drugs scene. After methylone was also banned, N-ethylpentylone emerged in In the latest festival season, three other cathinones reared their heads. Two of the three most common cathinones identified by The Loop in this study were legal in the Netherlands during the festival season, though have since been banned. Dr Michael Pascoe. Skip to main content. Search the website Search Close. Menu Menu. Undergraduate Explore subjects Courses Why study with us? Applying Funding Tuition fees Meet our student bloggers Prospectus Parents and supporters Teachers and careers advisers. Postgraduate Explore subjects Why study with us? International Your country Global events Funding and fees English language requirements English language programmes Foundation and pre-master's programmes European Exchange Study abroad in Cardiff Graduate visa route Prospectus Career support for international students Educational advisors. Innovation and impact Research impact Honours and accolades Our innovators Strategic alliances Quality and performance Informing Policy webinar series. Our research environment Supporting researchers Working collaboratively Integrity and ethics Funding and awards. News and features. Why work with us? Who we work with For suppliers Strategic direction Contact us Offer a discount to our staff. Use our expertise Business consultancy Funded opportunities License our research findings Knowledge exchange Advertise a civic engagement opportunity. Facilities Networking and events Business news. Our ambition Embracing community engagement Building Wales' skills for the future Leading Wales' green recovery Promoting Welsh language and culture. Supporting young people Helping young people reach their potential Educational resources and activities for teachers, schools and colleges Our priority groups. Events Use our facilities Take part in research Fundraise for our research. Global research Meet our people International students. Facts and figures Rankings Quality marks. Honours and awards Honorary Fellows. Share this story. Twitter facebook LinkedIn. News The latest from Cardiff University.

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