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JWH-018 (1-pentyl-3-(1-naphthyl)indole) or AM-678is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC).

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JWH-018, also known as(1-pentyl-3-(1-naphthyl)indole), is a synthetic cannabinoid research chemical, and EZRC is the first to stock.

It is a carbazole-based cannabinoid that is the carbazole analog of JWH-018, so it is perfect for researchers in countries where other cannabinoids are controlled. Like chemicals such as THJ-018 and AB-PINACA, it has relatively low in-vitro CB1/CB2 activity but is still interesting for researchers who like to study that type of synthetic cannabinoid. Buy JWH-250 Online

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Scientists can conduct experiments to determine the primary data on the material, such as melting points, solubilities, etc., and see how it compares and contrasts with the data from similar chemicals.

EZRC stock EG-018 in the form of an off-white, high-purity powder.

JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678is an analgesic chemical. The naphthoylindole family acts as a full agonist at the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC). A cannabinoid is naturally present in cannabis. This leads to its use in synthetic cannabis products such as “legal cannabis herbal incense blends,” which in some countries are sold legally as “incense,” labeled “not for humans. Buy JWH-250 Online

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JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors. With a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2. JWH-018 has an EC50 of 102 nM for human CB1 receptors and 133 nM for human CB2 receptors. JWH-018 produces bradycardia and hypothermia in rats at 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.

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