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The utility of nails in forensic toxicology for the analysis of drugs-of-abuse is examined. This chapter reviews the basic structure of the nail, mechanisms of drug incorporation, drugs-of-abuse that have been detected in nails, analytical methodologies, interpretation of results, advantages and disadvantages, and a chronological review of the literature. This is a preview of subscription content, log in via an institution to check access. Institutional subscriptions. Unable to display preview. Download preview PDF. Holtzberg M. Nail signs of systemic disease. Atlas of Hair and Nails. Philadelphia, PA: Churchill Livingstone, ;59— Google Scholar. Nail pigmentation abnormalities. Dermatol Clin ;3 3 — PubMed Google Scholar. Nail changes caused by systemic drugs or ingestants. Arsenic in the hair and nails. Its significance in acute arsenical poisoning. J Forensic Med ;12 2 — Shapiro HA. Arsenic content of human hair and nails. Its interpretation. J Forensic Med ;14 2 — Arsenic in fingernails. J Forensic Sci Soc 3 ;— Death by arsenic: a comparative evaluationof exhumed body tissues in the presence of external contamination. J Anal Toxicol ;— The nail and hair in forensic science. J Am Acad Dermatol ;50 2 — Article PubMed Google Scholar. Lead in tissues of deceased lead smelter workers. J Trace Elem Med Biol ;9 3 — Monitoring of cadmium, copper, lead and zinc status in young children using toenails: comparison with scalp hair. Sci Total Environ ; — The content of trace elements Cu, Zn, Fe, Mg in fingernails of children. Dermatologica ; 6 — Itraconazole penetrates the nail via the nail matrix and the nail bed: an investigation in onychomycosis. Clin Exp Dermatol ;16 5 : — Posttreatment itraconazole levels in the nail. New implications for treatment in onychomycosis. J Am Acad Dermatol. The uptake of fluconazole in finger and toe nails. Int J Clin Pharmacol Ther ;37 7 — Determination of terbinafine in nail samples during systemic treatment for onychomycoses. Br J Dermatol ; 4 : — Schafer-Korting M. Pharmacokinetic optimisation of oral antifungal therapy. Clin Pharmacokinet ;25 4 — Nail incorporation kinetics of terbinafine in onychomycosis patients. Clin Exp Dermatol ;20 5 — Human scalp hair as evidence of individual dosage history of haloperidol: method and retrospective study. Eur J Clin Pharmacol ;37 3 — Nails as useful materials for detection of methamphetamine or amphetamine abuse. Forensic Sci Int ;24 1 :9— Fleckman P. Anatomy and physiology of the nail. Johnson M, Shuster S. Continuous formation of nail along the bed. Br J Dermatol ; 3 — Studies of growth throughout the lifespan in Japanese: growth and size of nails and their relationship to age, sex, heredity, and other factors. J Gerontol ;10 4 — Jemec GB, Serup J. Ultrasound structure of the human nail plate. Arch Dermatol ; 5 — Zaias N. The movement of the nail bed. J Invest Dermatol ;48 4 — Zaias N, Alvarez J. The formation of the primate nail plate. An autoradiographic study in squirrel monkey. J Invest Dermatol ;51 2 — Norton LA. Incorporation of thymidine-methyl-H3 and glycineH3 in the nail matrix and bed of humans. J Invest Dermatol ;56 1 — Nail is produced by the normal nail bed: a controversy resolved. Br J Dermatol ; 1 — The unexpectedly rapid response of fungal nail infection to short duration therapy. Acta Derm Venereol ;72 2 — Shuster S, Munro CS. Single dose treatment of fungal nail disease. Lancet ; The disposition of cocaine and opiate analytes in hair and fingernails of humans following cocaine and codeine administration. J Anal Toxicol ;24 7 — The analysis of methadone in nail clippings from patients in a methadone-maintenance program. J Anal Toxicol. Drugs in nails: physiology, pharmacokinetics and forensic toxicology. Clin Pharmacokinet ;38 2 — Antifungal pulse therapy for onychomycosis. A pharmacokinetic and pharmacodynamic investigation of monthly cycles of 1-week pulse therapy with itraconazole. Arch Dermatol ; 1 — Levels of terbinafine in plasma, stratum corneum, dermis-epidermis without stratum corneum , sebum, hair and nails during and after mg terbinafine orally once per day for four weeks. Acta Derm Venereol ;73 4 — Analysis of methamphetamine in hair, nail, sweat, and saliva by mass fragmentography. J Anal Toxicol ;13 3 — Detection of amphetamines in fingernails: an alternative to hair analysis. Arch Toxicol. Deposition characteristics of methamphetamine and amphetamine in fingernail clippings and hair sections. Detection of cocaine analytes and opiates in nails from postmortem cases. J Anal Toxicol ;26 7 — In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs. Eur J Pharm Sci ;21 4 — Cocaine and benzoylecgonine concentrations in hair, nails and tissues: a comperative study of ante and postmortem materials in a case of an acute lethal cocaine intoxication. In: Tampa, FL, V. Spiehler, eds. Newport Beach, CA, , pp — Skopp G, Potsch L. A case report on drug screening of nail clippings to detect prenatal drug exposure. Ther Drug Monit ;19 4 — Detection of drugs of abuse in nails. J Anal Toxicol ; 22 4 — Identification of cocaine analytes in fingernail and toenail specimens. J Forensic Sci ;43 5 — J Anal Toxicol ;23 3 — J Forensic Sci ;45 2 — Simultaneous detection and quantitation of morphine, 6-acetylmorphine, and cocaine in toenails: comparison with hair analysis. J Anal Toxicol ;28 2 — Ragoucy-Sengler C, Kintz P. Detection of smoked cocaine marker anhydroecgonine methylester in nails. In: M. LeBeau, ed. Personal Communication , Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Garside, D. Drugs-of-Abuse in Nails. In: Jenkins, A. Forensic Science And Medicine. Humana Press. Publisher Name : Humana Press. Print ISBN : Online ISBN : Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Drug Testing in Alternate Biological Specimens. Summary The utility of nails in forensic toxicology for the analysis of drugs-of-abuse is examined. Access this chapter Log in via an institution. Chapter EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only. Preview Unable to display preview. Findings of illicit drugs in hair of children at different ages Article 03 January Contamination of a drug consumption room with drugs and potential risks for social health care workers Article Open access 16 August References Holtzberg M. Google Scholar Download references. Authors Diana Garside View author publications. Rights and permissions Reprints and permissions. About this chapter Cite this chapter Garside, D. Copy to clipboard. Publish with us Policies and ethics. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

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