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Tolerance was induced in mice to the antinociceptive effect of heroin by repeated subcutaneous injections of this narcotic analgesic for 3 days. A single oxytocin injection prior to the first challenge with heroin was as active in attenuating heroin tolerance as daily treatments with the neuropeptide. A single injection of oxytocin prior to the least heroin challenge also attenuated the expression of tolerance. The neuropeptide failed to modify the acute antinociceptive effect of heroin. It is concluded, therefore, that oxytocin interferes with mechanisms involved in the development and expression of tolerance to heroin. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. J Pharmacol Exp Ther — Google Scholar. Psychopharmacology — Pharmacol Rev — Peptides — Brain Res — Neuropharmacology in press. Behav Brain Res —8. Life Sci in press. Science — Eur J Pharmacol — Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Oxytocin diminishes heroin tolerance in mice. Psychopharmacology 86 , — Download citation. Received : 15 January Accepted : 19 March Issue Date : June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Home Psychopharmacology Article Oxytocin diminishes heroin tolerance in mice Rapid Communications Published: June Volume 86 , pages —, Cite this article. Psychopharmacology Aims and scope Submit manuscript. Abstract Tolerance was induced in mice to the antinociceptive effect of heroin by repeated subcutaneous injections of this narcotic analgesic for 3 days. Access this article Log in via an institution. View author publications. Rights and permissions Reprints and permissions. Copy to clipboard. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

Oxytocin diminishes heroin tolerance in mice

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Address: Pavla Papa str. No 46, Novi Sad, Serbia. Address: Kossuth Lajos sgt. Novi Sad - Szeged cross-border cooperation in development of harmonized methods and production of common database for the analysis of designer drugs. Project status: closed. Last month that data in keep. We use our own cookies and also allow third parties to use cookies, web beacons, and other technologies in order to better reach any web users that can benefit from using keep. Do you agree? Click the button or continue using the website. No, give me more information. About keep. Contact Login Register. Send message Close. Date of latest update: Description Description EN : The main objective of this Project is to strengthen the capacity of the police forensic laboratory and criminalistic police officers for chemical analysis of drugs in the border areas of the two countries, in order to combat illicit drug trafficking and organized crime. Besides the so-called classic drugs such as heroin, cocaine, MDMA, cannabis, numerous new synthetic compounds appeared on the black market. Majority of the new synthetic designer drugs are not under local and international control even though they are more dangerous than classic drugs. Consequently, the appropriate official handling of the newly appeared drugs is a very important task of the drug enforcement agencies. Efficient illicit drugs combat is possible only by applying the state of the art analytical instruments, which forensic labs in Novi Sad and Szeged at the moment don't have, in order to identify and quantify various designer drugs and their concomitant components. Because of that, the Project realization will lead to purchase of the devices and relevant reference materials of designer drugs which will allow training for the staff of participating laboratories to work on it and development of new analytical designer drugs procedures, improvement of existing analytical drug database in Hungary and creation of analitycal designer drugs database in Novi Sad lab. Designer drugs analytical database that will be formed in Novi Sad will be the first of its kind in Serbia. The second segment of the project will be organized through equipping and training of the criminalistic police officers for the spot test utilisation in order to introduce them to necessity and practical use of the preliminary drug tests in ordinary practise. This Project will represent the development of already created collaboration between the Ministries of Interior of our two countries and will contribute to an active prevention of organized crime and border safety strengthening. Achievements EN : The main objective of this project was to strengthen the capacities of the police forensic laboratory and criminal investigation police officers in performing chemical analyses of drugs in the border areas of the two countries, in order to combat illicit drug traffcking and organised crime. Apart from the so-called classic drugs such as heroin, cocaine, MDMA and cannabis, numerous new synthetic compounds have appeared on the black market. The majority of new synthetic designer drugs are not under local or international control, even though they are more dangerous than the classic drugs. Consequently, the appropriate of. Thematic information Safety. Partners map Partners and Projects info. Partners and Projects info. Lead partner. Project partner. Summary Project name EN : Novi Sad - Szeged cross-border cooperation in development of harmonized methods and production of common database for the analysis of designer drugs. Information regarding the data in keep. Notes on the data. Information provided by the Programme and collected from programme's Website. Disclaimer We use our own cookies and also allow third parties to use cookies, web beacons, and other technologies in order to better reach any web users that can benefit from using keep.

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