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Back to Addiction support. If you need treatment for drug addiction, you're entitled to NHS care in the same way as anyone else who has a health problem. With the right help and support, it's possible for you to get drug free and stay that way. A GP is a good place to start. They can discuss your problems with you and get you into treatment. They may offer you treatment at the practice or refer you to your local drug service. If you're not comfortable talking to a GP, you can approach your local drug treatment service yourself. Visit the Frank website to find support near you. If you're having trouble finding the right sort of help, call the Frank drugs helpline on They can talk you through all your options. As well as the NHS, there are charities and private drug and alcohol treatment organisations that can help you. Visit the Adfam website to see a list of useful organisations. Private drug treatment can be very expensive, but sometimes people get referrals through their local NHS. At your first appointment for drug treatment, staff will ask you about your drug use. They'll also ask about your work, family and housing situation. Staff will talk you through all of your treatment options and agree a treatment plan with you. They can tell you about local support groups for drug users and their families or carers. You'll also be given a keyworker, who will support you throughout your treatment. Your treatment will depend on your personal circumstances and what you're addicted to. Your keyworker will work with you to plan the right treatment for you. Your treatment plan may include a number of different treatments and strategies. Talking therapies, such as CBT , help you to see how your thoughts and feelings affect your behaviour. If you're dependent on heroin or another opioid, you may be offered a substitute drugs, such as methadone or buprenorphine. This means you can get on with your treatment without having to worry about withdrawing or buying street drugs. This is for people who want to stop taking opioids like heroin completely. It helps you to cope with the withdrawal symptoms. Your keyworker can tell you where your nearest group is. Staff at your local drug service will help reduce the risks associated with your drug-taking. You may have your treatment while living at home or as a hospital inpatient. If your drug-related problems are severe or complicated, you may be referred to a residential rehabilitation service. For more information about residential rehabilitation, or to find a rehab near you, visit Rehab-Online. Page last reviewed: 13 February Next review due: 13 February Drug addiction: getting help. Where to get help for drugs A GP is a good place to start. Charity and private drugs treatment As well as the NHS, there are charities and private drug and alcohol treatment organisations that can help you. Your first appointment At your first appointment for drug treatment, staff will ask you about your drug use. You may be asked to provide a sample of urine or saliva. What drug treatment involves Your treatment will depend on your personal circumstances and what you're addicted to. Talking therapies Talking therapies, such as CBT , help you to see how your thoughts and feelings affect your behaviour. Treatment with medicines If you're dependent on heroin or another opioid, you may be offered a substitute drugs, such as methadone or buprenorphine. Detoxification detox This is for people who want to stop taking opioids like heroin completely. Reducing harm Staff at your local drug service will help reduce the risks associated with your drug-taking. Where you'll have your treatment You may have your treatment while living at home or as a hospital inpatient.

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We can connect you with trained cancer information specialists who will answer questions about a cancer diagnosis and provide guidance and a compassionate ear. We connect patients, caregivers, and family members with essential services and resources at every step of their cancer journey. Ask us how you can get involved and support the fight against cancer. Some of the topics we can assist with include:. Colorectal Cancer. As researchers learn more about changes in cells that cause colon or rectal cancer, they have developed new types of drugs to specifically target these changes. Targeted drugs work differently from chemotherapy chemo drugs. They can be used either along with chemo, by themselves, or in combination with another targeted therapy drug. Like chemotherapy, these drugs enter the bloodstream and reach almost all areas of the body, which makes them useful against cancers that have spread to distant parts of the body. Vascular endothelial growth factor VEGF is a protein that helps tumors form new blood vessels a process known as angiogenesis to get nutrients they need to grow. Drugs that stop VEGF from working can be used to treat some colon or rectal cancers. These include:. Most of these drugs are given as infusions into your vein IV every 2 or 3 weeks, in most cases along with chemotherapy. Fruquinitinib is given as a capsule and not combined with chemotherapy. These drugs can often help people with advanced colon or rectal cancers live longer. Rare but possibly serious side effects include blood clots, severe bleeding, holes forming in the colon called perforations , heart problems, kidney problems, and slow wound healing. If a hole forms in the colon, it can lead to severe infection and surgery may be needed to fix it. Another rare but serious side effect of these drugs is an allergic reaction during the infusion, which could cause problems with breathing and low blood pressure. Epidermal growth factor receptor EGFR is a protein that helps cancer cells grow. The combination of these two drugs appears to help people with advanced colorectal cancer live longer. The most common side effects of these drugs are skin problems such as an acne-like rash on the face and chest during treatment, which can sometimes lead to infections. Developing this rash often means the cancer is responding to treatment. People who develop this rash often live longer, and those who develop more severe rashes also seem to respond better than those with a milder rash. Other side effects can include:. A rare but serious side effect of these drugs is an allergic reaction during the infusion, which could cause problems with breathing and low blood pressure. You may be given medicine before treatment to help prevent this. Other serious but rare serious side effects include eye, heart, or lung damage. A small portion of colorectal cancers have changes mutations in the BRAF gene. Colorectal cancer cells with these changes make an abnormal BRAF protein that helps them grow. Some drugs target this abnormal BRAF protein. When given with cetuximab or panitumumab, an EGFR inhibitor see above , this drug can shrink or slow the growth of colorectal cancer in some people whose cancer has spread. The combination of these two drugs also appears to help people with advanced colorectal cancer live longer. Common side effects of encorafenib, in combination with an EGFR inhibitor, can include skin thickening, diarrhea, rash, loss of appetite, abdominal pain, joint pain, fatigue, and nausea. Some people treated with a BRAF inhibitor might develop new squamous cell skin cancers. These cancers can often be treated by removing them. Still, your doctor will want to check your skin regularly during treatment and for several months afterward. You should also let your doctor know right away if you notice any new growths or abnormal areas on your skin. In a small percentage of people with colorectal cancer, the cancer cells have too much of a growth-promoting protein called HER2 on their surface. Drugs that target the HER2 protein can often be helpful in treating these cancers. For advanced, HER2-positive colorectal cancer that has already been treated with chemotherapy, the most common targeted drug regimens include trastuzumab plus either tucatinib, lapatinib, or pertuzumab. Among these drugs, only tucatinib is FDA approved specifically to treat colorectal cancer at this time, but the others are present in treatment guidelines. The side effects of HER2-targeted drugs tend to be mild overall, but some can be serious, and different drugs can have different possible side effects. Discuss what you can expect with your doctor. Some of these drugs can cause heart damage during or after treatment, which might lead to congestive heart failure. Because of this, your doctor will likely check your heart function with an echocardiogram or a MUGA scan before treatment, and regularly while you are getting any of these drugs. Let your doctor know if you develop symptoms, such as shortness of breath, a fast heartbeat, leg swelling, and severe fatigue. Lapatinib and tucatinib can also cause hand-foot syndrome , in which the hands and feet become sore and red, and may blister and peel. Lapatinib and tucatinib can cause liver problems. Your doctor will do blood tests to check your liver function during treatment. Let your health care team know right away if you have possible signs or symptoms of liver problems, such as itchy skin, yellowing of the skin or the white parts of your eyes, dark urine, or pain in the right upper belly area. Fam-trastuzumab deruxtecan can cause serious lung disease in some people, which might even be life threatening. A very small number of colorectal cancers have changes in one of the NTRK genes. This causes them to make abnormal TRK proteins, which can lead to abnormal cell growth and cancer. These drugs can be used to treat advanced cancers with NTRK gene changes that are still growing despite other treatments. Common side effects of these drugs can include dizziness, fatigue, nausea, vomiting, constipation, weight gain, and diarrhea. Less common but serious side effects can include abnormal liver tests, increased risk for fractures, heart problems, vision changes, and confusion. A very small number of colorectal cancers have changes in one of the RET genes. This causes them to make abnormal RET proteins, which can lead to abnormal cell growth and cancer. Selpercatinib Retevmo is a drug that targets the RET protein. These drugs can be used to treat advanced cancers with RET gene changes that are still growing despite other treatments. This drug is approved to treat other types of cancer, but doctors can prescribe it off-label for colorectal cancer. Common side effects of these drugs can include decrease in white blood cell count and calcium, changes in liver function tests, high blood pressure, fatigue, changes in kidney function, and increased cholesterol. Less common but serious side effects can include abnormal heart function QT interval prolongation , bleed, allergic reaction, and inability to heal from a wound. This causes them to make abnormal KRAS proteins, which can lead to continued cell growth and cancer. Sotorasib is not approved specifically to treat colorectal cancer at this time. It is approved to treat other types of cancer, but doctors can prescribe them off-label for colorectal cancer. Common side effects of these drugs can include nausea, vomiting, diarrhea, muscle and joint pain, fatigue, decreased appetite, and changes in liver and kidney function. Less common but serious side effects can include effects to the heart QTc interval prolongation , liver, and lungs interstitial lung disease. Regorafenib Stivarga is a type of targeted therapy known as a multikinase inhibitor. Regorafenib blocks several kinase proteins that either help tumor cells grow or help form new blood vessels to feed the tumor. Blocking these proteins can help stop the growth of cancer cells. This drug can be used to treat advanced colorectal cancer, typically when other drugs are no longer helpful. Common side effects include fatigue, rash, hand-foot syndrome redness and irritation of the hands and feet , diarrhea, high blood pressure, weight loss, and abdominal pain. Less common but more serious side effects can include confusion, severe bleeding, or perforations holes in the stomach or intestines. To learn more about how targeted drugs are used to treat cancer, see Targeted Cancer Therapy. To learn about some of the side effects listed here and how to manage them, see Managing Cancer-related Side Effects. The American Cancer Society medical and editorial content team. Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing. Kelly SR and Nelson H. Chapter 75 — Cancer of the Rectum. Philadelphia, Pa. Elsevier: Chapter 74 — Colorectal Cancer. Ch 62 - Cancer of the Colon. Ch 63 - Cancer of the Rectum. National Cancer Institute. Colon Cancer Treatment. Rectal Cancer Treatment. Int J Mol Sci. American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy. Sign up to stay up-to-date with news, valuable information, and ways to get involved with the American Cancer Society. If this was helpful, donate to help fund patient support services, research, and cancer content updates. Skip to main content. Sign Up For Email. Sign Up For Text Messages. Understanding Cancer What Is Cancer? Cancer Glossary Anatomy Gallery. Patient Navigation. End of Life Care. When Your Child Has Cancer. For Health Professionals. Cancer News. Explore All About Cancer. Resource Search. Explore Ways to Give. Making Strides Against Breast Cancer. Explore Get Involved. Explore Our Research. Explore About Us. Contact Us Online Help. Chat live online Select the Live Chat button at the bottom of the page. Call us at Available any time of day or night. Some of the topics we can assist with include: Referrals to patient-related programs or resources Donations, website, or event-related assistance Tobacco-related topics Volunteer opportunities Cancer Information For medical questions, we encourage you to review our information with your doctor. Colorectal Cancer About Colorectal Cancer. Download Section as PDF. Targeted Therapy Drugs for Colorectal Cancer. On this page. When is targeted therapy used? Several types of targeted drugs might be used to treat colorectal cancer. Drugs that target blood vessel formation VEGF Vascular endothelial growth factor VEGF is a protein that helps tumors form new blood vessels a process known as angiogenesis to get nutrients they need to grow. These include: Bevacizumab Avastin Ramucirumab Cyramza Ziv-aflibercept Zaltrap Fruquintinib Fruzaqla Most of these drugs are given as infusions into your vein IV every 2 or 3 weeks, in most cases along with chemotherapy. Possible side effects of drugs that target VEGF Common side effects of these drugs include: High blood pressure Protein in the urine Bleeding from the nose or rectum Headaches Taste changes Skin changes Rare but possibly serious side effects include blood clots, severe bleeding, holes forming in the colon called perforations , heart problems, kidney problems, and slow wound healing. These include: Cetuximab Erbitux Panitumumab Vectibix Both of these drugs are given by IV infusion, either once a week or every other week. Possible side effects of drugs that target EGFR The most common side effects of these drugs are skin problems such as an acne-like rash on the face and chest during treatment, which can sometimes lead to infections. Other side effects can include: Headache Tiredness Fever Diarrhea A rare but serious side effect of these drugs is an allergic reaction during the infusion, which could cause problems with breathing and low blood pressure. This drug is taken as capsules, once a day. Drugs that target cells with HER2 changes In a small percentage of people with colorectal cancer, the cancer cells have too much of a growth-promoting protein called HER2 on their surface. Drugs of this type that might be used to treat HER2-positive colorectal cancer include: Trastuzumab Herceptin, other names Pertuzumab Perjeta Tucatinib Tukysa Lapatinib Tykerb Fam-trastuzumab deruxtecan Enhertu, T-DXd For advanced, HER2-positive colorectal cancer that has already been treated with chemotherapy, the most common targeted drug regimens include trastuzumab plus either tucatinib, lapatinib, or pertuzumab. These drugs are taken as pills or an oral solution, once or twice daily. This drug is taken as a capsule twice daily. These drugs are taken as tablets, once or twice daily. Other targeted therapy drugs Regorafenib Stivarga is a type of targeted therapy known as a multikinase inhibitor. More information about targeted therapy To learn more about how targeted drugs are used to treat cancer, see Targeted Cancer Therapy. Written by References. The American Cancer Society medical and editorial content team Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing. Last Revised: June 28, American Cancer Society Emails Sign up to stay up-to-date with news, valuable information, and ways to get involved with the American Cancer Society. Sign Up for Email. More in Colorectal Cancer. Help us end cancer as we know it, for everyone. Donate with Confidence. Donate Now Maybe Later.

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