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Gray death: a powerful opioid combination leading to rapid fatality – correspondence

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Official websites use. Share sensitive information only on official, secure websites. Corresponding author. E-mail address: talhabmb bgctub. This is an open access article distributed under the Creative Commons Attribution License 4. Gray death is a street name or a slang term that is frequently used to describe a mixture of illegal drugs — mainly synthetic opioids and other synthetic narcotics. Psychoactive components such as heroin, fentanyl, or U an extremely strong synthetic opioid painkiller are commonly found in drug cocktails. Occasionally, it is in combination with other substances like cocaine, amphetamines, or other synthetic designer drugs. This mixture resembles concrete powder or tiny rocks in appearance. It can be injected intravenously, processed into a fine powder, snorted intranasally, smoked, or consumed orally in tablet form 1. This illicit drug first appeared in the South at the beginning of , mostly in Alabama and Georgia. This drug also spread in Ohio and Pennsylvania. Twenty persons in Argentina died in February from cocaine use linked with carfentanil 3. From January to April , the substance has been involved in at least 50 incidents and 17 overdoses in Georgia alone. The National Institute on Drug Abuse claims that it is not one drug but rather a mixture of several very strong opioids, including any that a drug dealer may have on hand. It generally includes the extremely potent addictive opioids Heroin, made from morphine found in the opium poppy Papaver somniferum plant. It also contains fentanyl, a synthetic opioid medicine up to times stronger than other opioids, and U Therefore, a dangerous designer drug is made; its low dosages can be fatal or deadly. It may include a dangerous combination of other highly strong opioids and toxins, such as carfentanil which is times stronger compared to fentanyl and 10 times stronger compared to morphine 5. The adverse effects of gray death can be mild to severe because no two batches are exactly the same in composition. Confusion, difficulty moving, tiredness, tremors, balance loss, seizures, mental fog, vomiting and nausea, myosis, spasms or generalized convulsion, and hypoventilation are some of the major side effects of gray death. Symptoms of gray death overdose include a faded or sweaty face, a languid body, grunting noises, purplish or bluish lips, shallow breathing, irregular pulse, and speech difficulties 4. Multiple doses of the opioid-reversing drug naloxone Narcan may be needed to treat gray death overdose. It is frequently used to combat respiratory problems brought on by opioid overdose. Some patients may require a maximum of 10 doses for healing 6. When using buprenorphine and naloxone to treat overdoses of strong narcotics from the fentanyl group, problems may frequently develop. When it comes to the potential of overdosing, gray death may be the scariest of all drugs. Nowadays, the National Institutes of Health, along with private organizations, are collaborating together on three distinct sectors: the development of enhanced overdose-reversing medications and preventative strategies to reduce death rates, the protection of lives and recovery through innovative pharmaceutical and technological remedies, and the discovery of effective, nonaddictive, and safe treatments for chronic pain 7. Hyperlink to your specific registration must be publicly accessible and will be checked : not applicable. We have read and understood the policy on the declaration of interests and have no relevant interests to declare. The responsibility for the content lies with the author, and the views stated herein should not be taken to represent those of any organizations or groups with and for which he works. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. This section collects any data citations, data availability statements, or supplementary materials included in this article. As a library, NLM provides access to scientific literature. Ann Med Surg Lond. Find articles by Tanvir Hasan. Find articles by Saad A Sami. Find articles by Jaytirmoy Barmon. Find articles by Mohammed K Hossain. Find articles by Talha B Emran. Published by Wolters Kluwer Health, Inc. Tanvir Hasan and Saad A. Sami contributed equally to this article. Similar articles. Add to Collections. Create a new collection. Add to an existing collection. Choose a collection Unable to load your collection due to an error Please try again. Add Cancel.

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