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Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Anti-inflammatory painkillers like diclofenac, ibuprofen and naproxen can help relieve severe period pain. These medications sometimes have side effects such as stomach and digestion problems. Period pains and cramps dysmenorrhea are common. Most girls and women have pain of varying intensity at some point during their period. In some women the pain is so bad that they're unable to carry out their usual daily activities, like going to work or school, on one to three days every month. In many women who have bad period pains, the womb produces too much of the chemical messenger prostaglandin. This leads to painful cramps in the lower abdomen that might also radiate into the back or thighs. Benign non-cancerous growths such as fibroids sometimes play a role too. Very severe period pain can also be a symptom of endometriosis , where the type of tissue that lines the womb grows outside of the womb. Anti-inflammatory painkillers can be taken to relieve period pain, especially the drugs diclofenac, ibuprofen and naproxen. They inhibit the production of prostaglandins and can relieve period pain in that way. Researchers at the Cochrane Collaboration — an international network of researchers — looked for studies of these drugs to find out whether they help and how well they are tolerated. The researchers found 80 good-quality studies involving more than 5, girls and women between the ages of 12 and These studies compared the effectiveness of the painkiller with that of a placebo fake drug or other medications. The studies included women with and without endometriosis. There's not enough good research to be able to say whether some NSAIDs are more effective than others. IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services. Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. We do not offer individual consultations. Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods. Turn recording back on. Help Accessibility Careers. Search term. Period pain: Research summaries — Period pains: Can anti-inflammatory drugs help? Last Update: May 12, ; Next update: Painkillers block prostaglandin production Anti-inflammatory painkillers can be taken to relieve period pain, especially the drugs diclofenac, ibuprofen and naproxen. Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. In this Page. Informed Health Links. Related information. Recent Activity. Clear Turn Off Turn On. Follow NCBI.

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