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Analysis of postmortem samples with the presence of morphine can sometimes be challenging to interpret. Tolerance complicates interpretation of intoxications and causes of death due to overlap in therapeutic and fatal concentrations. Determination of metabolites and metabolic ratios can potentially differentiate between abstinence, continuous administration, and perhaps time of administration. Validation parameters such as precision, bias, matrix effects, stability, process efficiency, and dilution integrity were assessed and deemed acceptable. Lower limits of quantitation ranged from 0. Cases were divided into three groups based on CoD; opiate intoxication, intoxication with other drugs than opiates, and other CoD. Five cases were classified as mixed intakes and excluded. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign in through your institution. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Materials and Methods. Supplementary data. Journal Article. Gerd Jakobsson , Gerd Jakobsson. E-mail: gerd. Oxford Academic. Google Scholar. Michael T Truver. Sonja A Wrobel. Robert Kronstrand. Revision received:. Editorial decision:. Select Format Select format. Permissions Icon Permissions. Abstract Analysis of postmortem samples with the presence of morphine can sometimes be challenging to interpret. Issue Section:. Download all slides. Views 3, More metrics information. Total Views 3, Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic. Citing articles via Web of Science The rise of bromazolam in postmortem cases from Travis County, TX, and surrounding areas: to More from Oxford Academic. Biological Sciences. Clinical Medicine. Medical Toxicology. Medicine and Health. Science and Mathematics. Toxicology Non-medical. Authoring Open access Purchasing Institutional account management Rights and permissions. Get help with access Accessibility Contact us Advertising Media enquiries.

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