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A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure MOE approach was conducted. The MOE is defined as ratio between toxicological threshold benchmark dose and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco high risk and cannabis low risk. Abstract A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure MOE approach was conducted. Substances Illicit Drugs Ethanol.

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