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Background: Ascorbic acid vitamin C , administered orally in high doses has been observed to relieve pain and reduce opioid use in cancer patients. In vitro studies have also shown that antioxidants, such as vitamin C, may, at high concentrations, inhibit the endogenous opioid degrading metalloenzyme and increase endorphin levels. In the present study the effects of oral administration of high doses of vitamin C on withdrawal syndrome of heroin abusers were investigated. The results on the intensity of withdrawal syndrome WS , estimated according to DMS-III criteria, were compared to a third group of heroin addict in-patients group C, 30 males-control group , treated only by conventional medication. Results: The patients of the vitamin C-treated groups in-patients and out-patients experienced mild WS in Conclusions: The results indicate that high doses of ascorbic acid administered orally, may ameliorate the withdrawal syndrome of heroin addicts. Further studies are needed in order to estimate the dose- and time-dependent effects of ascorbic acid treatment, and to clarify its mechanisms of action in the withdrawal syndrome. Abstract Background: Ascorbic acid vitamin C , administered orally in high doses has been observed to relieve pain and reduce opioid use in cancer patients. Publication types Clinical Trial Comparative Study.

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A short distance ahead lies the porous border with Albania. This is the biggest land route for cannabis trafficking in Europe. The Greek border village of Haravgi Ioannina is nearby, but there is no barbed wire or any other barrier to mark the frontier. They can survive for days in the forest. Greek police have confiscated 1. The previous two years, they seized almost nine tonnes. The smugglers, usually armed with Kalashnikovs, carry bags filled with kg of cannabis on their backs. They hide the drugs near designated spots - a large tree or a fountain - and the bags are then picked up by members of a Greek network. Police stage regular raids on both sides of the border, but the smuggling continues. All that was meant to change in the summer of , when Albanian special forces launched a major operation in the village of Lazarat, about 30km from the Greek border. Several days of battles ensued. Rocket-propelled grenades and mortar shells were fired at police, but by the end more than 10 tonnes of marijuana, thousands of cannabis plants and firearms were confiscated. And yet by , Albania's cannabis economy had spread throughout the country, according to the Global Initiative Against Transnational Organized Crime. The Balkans already lay on one of the most established drug-trafficking routes in the world. Now, cannabis was profiting village growers as well as organised crime groups selling it across the European Union. To a generation of young Albanians, the illicit trade offered a way of making money, as it did for civil servants, police and politicians, according to the Global Initiative. Artan, 39, is one of Albania's young cannabis producers on the make. Sitting in a bar in the coastal city of Vlore, he explains how you can make a fortune, at least until you get caught. Artan's not his real name. He spent two years in Italy but came back to run the business from his home. He claims to have planted 50, cannabis plants this year alone, a big number even by Albanian standards. He pumps water from a spring 2km away and has his father pick up fertiliser, so he is not himself caught on CCTV. When the cannabis is ready for sale, it is moved to a village near the border. Then the smugglers take it 'either on foot or on mules across Greek territory'. Albanian Prime Minister Edi Rama promised there would be no let-up in the war on drugs as he pushed for entry to the European Union. But little changed and cannabis producers began seeking new markets - not just Greece and Italy, but Turkey, Germany, the Netherlands and the UK too. The US state department's annual drug report this year described Albania as a ' home base for transnational organised crime networks involved in trafficking illicit narcotics across Europe and beyond'. Now, the Albanian leader has sought to turn this illicit trade into a legitimate economic asset. In May, he abruptly announced that the government had been working on a bill to legalise medical cannabis for the past year and that illegal cultivation was under control. Albania not only has to tackle organised crime and corruption, it also has to convince the European Union it is doing so. So far nothing has been lined up, a senior government official has told the BBC. And the experience of Albania's neighbours suggests there will no quick fix:. Albanian police have begun using drones to find the main illicit cannabis plantations that have sprung up. But dense forest either side of the Greek border makes the task of tracking down the smugglers even harder on Europe's biggest cannabis route. Vladimir Karaj contributed reporting from Tirana. Skip to content. US Election. Why Europe's big cannabis route is so hard to shut. Alexandros Avramidis. These two bags containing up to 50kg cannabis were seized on the border. Albania battles cannabis growers. Getty Images. By the time of the gun battles, Lazarat had become known as Europe's cannabis capital. A producer's story. Greek police. Cannabis production and smuggling into Greece has become a big lure for young Albanians. Afghanistan, home to heroin trade, moves into meth Hidden fortune found in Pablo Escobar's house. Greece has legalised both industrial hemp and medical cannabis but to little economic effect In North Macedonia medical cannabis production is legal, but tonnes of cannabis buds and cannabis oil are sitting in storage. The longer it remains there, the greater the risk it will find its way on to the illegal market. Jim Connolly has been investigating how social media is being used to sell drugs. Drugs trade.

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